Exploration and exploit of intratumor microenvironment for both controlling local tumors and reducing distant metastatic potential

• Project/Area Number: 23300348
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Kyoto University
• Principal Investigator: MASUNAGA Shin-ichiro 京都大学, 原子炉実験所, 教授 (80238914)
• Co-Investigator(Kenkyū-buntansha): NAGASAWA Hideko 岐阜薬科大学, 薬学部, 教授 (90207994) ; TANO Keizo 京都大学, 原子炉実験所, 准教授 (00183468)
• Project Period (FY): 2011-11-18 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 休止期腫瘍細胞 / 急性低酸素 / 慢性低酸素 / 酸素化休止期腫瘍細胞 / 癌幹細胞 / 中性子捕捉療法 / CBE値 / 腫瘍血管正常化現象 / 遠隔転移制御 / ベバシツマブ / 急性低酸素細胞分画 / 腫瘍不均一性 / 酸素化休止期腫瘍細胞分画 / 低温度温熱処置 / ティラパザミン / ウォルトマニン / 分割ウォルトマニン投与 / 加速炭素イオン線 / 中性子捕捉反応 / sodium borocaptate-10B(BSH) / L-para-boronophenylalanin-10B / 中性子捕捉療法(BNCT) / インテグリンαvβ3受容体 / サイクロデキストリン

Research Abstract

Based on the developed method both for detecting the potential for controlling local tumors including intratumor quiescent cells and for evaluating pulmonary distant metastases from local tumors, releasing intratumor acute hypoxia leads to reduction of pulmonary metastatic potential, and boron neutron capture therapy with BSH (sodium borocaptate-10B) and with BPA (L-para-boronophenylalanin-10B) result in increasing the potential for controlling local tumors and suppressing the pulmonary distant metastatic potential, respectively.
Intratumor oxic quiescent cells were shown to have a greater recovery capacity like cancer stem cells, but not hypoxic, through selectively detecting their radio-sensitivity.
The compound biological effectiveness values for neutron capture agents that deliver into solid tumors more dependently on uptake capacity of tumor cells became more changeable. The value may be one of the indices showing the degree of tumor heterogeneity.

Research Products

• [Journal Article] The dependency of compound biological effectiveness factors on the type and the concentration of administered neutron capture agents in boron neutron capture therapy (2014)
  • Author(s): Masunaga S, Sakurai Y, Tanaka H, Tano K, et al. 計11名
  • Journal Title: Springer Plus Volume: 3 Issue: 1 Pages: 128-128
  • DOI: 10.1186/2193-1801-3-128
  • NAID: 120005439170
  • Peer Reviewed / Open Access
• [Journal Article] Significance of administering bevacizumab combined with boron neutron capture therapy in terms of local tumor response and lung metastasis (2014)
  • Author(s): Masunaga S, Sakurai Y, Tano K, et al. 計11名
  • Journal Title: Exp Ther Med Volume: 8 Issue: 1 Pages: 291-301
  • DOI: 10.3892/etm.2014.1704
  • Peer Reviewed / Open Access
• [Journal Article] Boron neutron capture therapy outcomes for advanced or recurrent head and neck cancer (2014)
  • Author(s): Suzuki M, Kato I, Aihara T, Hiratsuka J, Yoshimura K, Niimi M, Kimura Y, Ariyoshi Y, Haginomori S, Sakurai Y, Kinashi Y, Masunaga S, et al, 計15名
  • Journal Title: J Radiat Res Volume: 55(1) Issue: 1 Pages: 146-153
  • DOI: 10.1093/jrr/rrt098
  • Peer Reviewed
• [Journal Article] High linear-energy-transfer radiation can overcome radioresistance of glioma stem-like cells to low linear-energy-transfer radiation (2014)
  • Author(s): Hirota Y, Masunaga S, Kondo N, et al. 計10名
  • Journal Title: J Radiat Res Volume: 55(1) Issue: 1 Pages: 75-83
  • DOI: 10.1093/jrr/rrt095
  • Peer Reviewed
• [Journal Article] Dose estimation for internal organs during boron neutron capture therapy for body-trunk tumors (2014)
  • Author(s): Sakurai Y, Tanaka H, Suzuki M, Masunaga S, et al. 計8名
  • Journal Title: Appl.Radiat.Isotopes Volume: 88 Pages: 43-45
  • DOI: 10.1016/j.apradiso.2014.03.005
  • Peer Reviewed
• [Journal Article] Evaluation of thermal neutron irradiation field using a cyclotron-based neutron source for alpha autoradiography (2014)
  • Author(s): Tanaka H, Sakurai Y, Suzuki M, Masunaga S, et al. 計13名
  • Journal Title: Appl.Radiat.Isotopes Volume: 88 Pages: 153-156
  • DOI: 10.1016/j.apradiso.2014.01.011
  • Peer Reviewed
• [Journal Article] Pilot clinical study of boron neutron capture therapy for recurrent hepatic cancer involving the intra-arterial injection of a ^<10>BSH-containing WOW emulsion (2014)
  • Author(s): Yanagie H, Higashi S, Seguchi K, Ikushima I, Fujihara M, Nonaka Y, Oyama K, Maruyama S, Hatae R, Suzuki M, Masunaga S, et al. 計23名
  • Journal Title: Appl Radiat Isot Volume: 72 Pages: 21-29
  • DOI: 10.1016/j.apradiso.2014.01.014
  • Peer Reviewed
• [Journal Article] Significance of administering bevacizumab combined with boron neutron capture therapy in terms of local tumor response and lung metastasis. (2014)
  • Author(s): Masunaga S, Sakurai Y, Tano K, Tanaka H, Suzuki M, Kondo N, Narabayashi M, Watanabe T, Nakagawa Y, Maruhashi A, Ono K
  • Journal Title: Experimental and Therapeutic Medicine Volume: 7
  • Peer Reviewed
• [Journal Article] Radiosensitivity of pimonidazole-unlabelled intratumour quiescent cell population to γ-rays, accelerated carbon ion beams and boron neutron capture reaction, S.-I (2013)
  • Author(s): Masunaga, Y. Sakurai, H. Tanaka, et al
  • Journal Title: British Journal of Radiology Volume: 86(1021) Issue: 1021 Pages: 20120302-20120302
  • DOI: 10.1259/bjr.20120302
  • Peer Reviewed
• [Journal Article] Wortmannin efficiently suppresses the recovery from radiation-induced damage in pimonidazole-unlabeled quiescent tumor cell population (2013)
  • Author(s): Masunaga S, Sakurai Y, Tanaka H, et al. 計8名
  • Journal Title: J Radiat Res Volume: 54(2) Issue: 2 Pages: 221-229
  • DOI: 10.1093/jrr/rrs094
  • NAID: 120005244224
  • Peer Reviewed
• [Journal Article] Effect of tirapazamine and mild temperature hyperthermia on the recovery from radiation-induced damage in pimonidazole-unlabeled quiescent tumor cell population (2013)
  • Author(s): Masunaga S, Sakurai Y, Tanaka H, Suzuki M, Kondo N, Narabayashi M, Tano K, et al. 計9名
  • Journal Title: Journal of Cancer Therapy Volume: 4 Issue: 02 Pages: 521-528
  • DOI: 10.4236/jct.2013.42065
  • Peer Reviewed
• [Journal Article] Effect of bevacizumab treatment on p-boronophenylalanine distribution in murine tumor (2013)
  • Author(s): Y. Liu
  • Journal Title: J Radiat Res. Volume: 54(2) Issue: 2 Pages: 260-267
  • DOI: 10.1093/jrr/rrs102
  • Peer Reviewed
• [Journal Article] Evaluation of SCCVII tumor cell survival in clamped and non-clamped solid tumors exposed to carbon-ion beams in comparison to X-rays (2013)
  • Author(s): Hirayama R, Uzawa A, Takase N, Matsumoto Y, Noguchi M, Koda K, Ozaki M, Yamashita K, Li H, Kase Y, Matsufuji N, Koike S, Masunaga S, et al. 計16名
  • Journal Title: Mutat Res Volume: 756(1-2) Issue: 1-2 Pages: 146-151
  • DOI: 10.1016/j.mrgentox.2013.05.008
  • Peer Reviewed
• [Journal Article] Sonoporation as an enhancing method for boron neutron capture therapy for squamous cell carcinomas (2013)
  • Author(s): Yamamoto N, Iwagami T, Kato I, Masunaga S, et. Al. 計9名
  • Journal Title: Radiat Oncol Volume: 8 Issue: 1 Pages: 280-280
  • DOI: 10.1186/1748-717x-8-280
  • Peer Reviewed / Open Access
• [Journal Article] Development of a simple and rapid method of precisely identifying the position of ^<10>B atoms in tissue : an improvement in standard alpha autoradiography (2013)
  • Author(s): Tanaka H, Sakurai Y, Suzuki M, Masunaga S, Takamiya K, Maruhashi A, Ono K
  • Journal Title: J Radiat Res Volume: 56 Issue: 2 Pages: 373-380
  • DOI: 10.1093/jrr/rrt110
  • Peer Reviewed
• [Journal Article] Evaluation of SCCVII tumor cell survival in clamped and non-clamped solid tumors exposed to carbon-ion beams in comparison to X-rays. (2013)
  • Author(s): Hirayama R, Uzawa A, Takase N, Matsumoto Y, Noguchi M, Koda K, Ozaki M, Yamashita K, Li H, Kase Y, Matsufuji N, Koike S, Masunaga S, Ando K, Okayasu R, Furusawa Y
  • Journal Title: Mutation Research/Genetic Toxicology and Environmental Mutagenesis Volume: 756 Pages: 146-151
  • Peer Reviewed
• [Journal Article] Usefulness of daily fractionated administration of wortmannin combined with gamma-ray irradiation in terms of local tumor response and lung metastasis. (2013)
  • Author(s): 増永慎一郎、櫻井良憲、田中浩基、鈴木実、近藤夏子、楢林正流、田野恵三、丸橋晃、小野公二
  • Journal Title: World Journal of Oncology Volume: 4 Pages: 26-36
  • DOI: 10.4021/wjon640w
  • Peer Reviewed
• [Journal Article] Effects of Emplying a 10B-carrier and Manipulating Intratumor Hypoxia on Local Tumor Response and Lung Metastatic Potential in Boron Neutron Capture Therapy (2012)
  • Author(s): S. Masunaga
  • Journal Title: Br. J. Radiol. Volume: 85 Issue: 1011 Pages: 249-258
  • DOI: 10.1259/bjr/20974899
  • Peer Reviewed
• [Journal Article] Evaluating the Usefulness of a Novel 10B-Carrier Conjugated With Cyclic RGD Peptide in Boron Neutron Capture Therapy,S.-I (2012)
  • Author(s): Masunaga,S. Kimura,T. Harada,K. Okuda,Y. Sakurai,H. Tanaka,et al
  • Journal Title: World J Oncol Volume: 3(3) Pages: 103-112
  • DOI: 10.4021/wjon477w
  • Peer Reviewed
• [Journal Article] Usefulness of combined treatment with continuous administration of tirapazamine and mild temperature hyperthermia in γ-ray irradiation in terms of local tumor response and lung metastatic potential (2012)
  • Author(s): Masunaga S, Liu Y, Sakurai Y, et al. 計8名
  • Journal Title: Int J Hyperthermia Volume: 28(7) Issue: 7 Pages: 636-644
  • DOI: 10.3109/02656736.2012.714517
  • Peer Reviewed
• [Journal Article] Reirradiation for locally recurrent lung cancer in the chest wall with boron neutron (2012)
  • Author(s): Suzuki M.
  • Journal Title: International Cancer Conference Journal Volume: 1 Issue: 4 Pages: 235-238
  • DOI: 10.1007/s13691-012-0048-8
  • Peer Reviewed
• [Journal Article] Biological evaluation of dodecaborate-containing L-amino acids for boron neutron capture therapy. (2012)
  • Author(s): Y. Hattori
  • Journal Title: J Med Chem. Volume: 55(5) Issue: 15 Pages: 6980-6984
  • DOI: 10.1021/jm300749q
  • Peer Reviewed
• [Journal Article] Effects of employing a 10B-carrier and manipulating intratumour hypoxia on local tumor response and lung metastatic potential in boron neutron capture therapy (2012)
  • Author(s): Masunaga S, Sakurai Y, Tanaka H, Suzuki M, Liu Y, Kondo N, Maruhashi A, Kinashi Y, Odo K
  • Journal Title: Br J Radiol Volume: 85 Pages: 249-258
  • Peer Reviewed
• [Journal Article] Evaluating the usefulness of a novel 10B-carrier conjugated with cyclic RGD peptide in boron neutron capture therapy (2012)
  • Author(s): Masunaga S, Kimura S, Harada T, Okuda K, Sakurai Y, Tanaka H, Suzuki M, Kondo N, Maruhashi A, Nagasawa H, Ono K
  • Journal Title: World J Oncol Volume: (掲載確定)(印刷中)
  • Peer Reviewed
• [Journal Article] Reducing intratumor acute hypoxia through bevacizumab treatment, referring to the response of quiescent tumor cells and metastatic potential (2011)
  • Author(s): Masunaga S, Liu Y, Tanaka H, et al. 計9名
  • Journal Title: Br J Radiol Volume: 84(1008) Issue: 1008 Pages: 1131-1138
  • DOI: 10.1259/bjr/38457938
  • Peer Reviewed
• [Journal Article] Radiosensitivity and capacity to recover from radiation-induced damage in pimonidazole-unlabeled intratumor quiescent cells depend on p53 status (2011)
  • Author(s): Masunaga S, Liu Y, Tanaka H, et al. 計8名
  • Journal Title: World J Oncol Volume: 2(1) Pages: 1-9
  • DOI: 10.4021/wjon272w
  • Peer Reviewed
• [Journal Article] Evaluation of the In vivo Radiosensitizing Activity of Etanidazole Using Tumor-bearing Chick Embryo (2011)
  • Author(s): Chiaki Abe, Yoshihiro Uto, Takashi Nakae, Yuuya Shinmoto, Keiichiro Sano, Hiroko Nakata, Mizue Teraoka, Yoshio Endo, Hiroshi Maezawa, Shin-ichiro Masunaga, Eiji Nakata and Hitoshi Hori
  • Journal Title: Journal of Radiation Research Volume: 52 Issue: 2 Pages: 208-214
  • DOI: 10.1269/jrr.10122
  • NAID: 10027956760
  • ISSN: 0449-3060, 1349-9157
  • Peer Reviewed
• [Journal Article] Synthesis and evaluation of cyclic RGD-boron cluster conjugates to develop tumor-selective boron carriers for boron neutron capture therapy (2011)
  • Author(s): Kimura S, Masunaga S, Harada T, Kawamura Y, Ueda S, Okuda K, Nagasawa H
  • Journal Title: Bioorg Med Chem Volume: 19(5) Issue: 5 Pages: 1721-1728
  • DOI: 10.1016/j.bmc.2011.01.020
  • Peer Reviewed
• [Journal Article] Experimental verification of beam characteristics for cyclotron-based epithermal neutron source(C-BENS) (2011)
  • Author(s): H. Tanaka, et. al.
  • Journal Title: Applied Radiation and Isotopes Volume: Volume 69 Issue: 12 Pages: 1642-1645
  • DOI: 10.1016/j.apradiso.2011.03.020
  • Peer Reviewed
• [Journal Article] Reducing intratumour acute bypoxia through bevacizumab treatment, referring to the response of quiescent tumour cells and metastatic potential (2011)
  • Author(s): Masunaga S, Liu Y, Tanaka H, Sakurai Y, Suzuki M, Kondo N, Maruhashi A, Ono K
  • Journal Title: Br J Radiol Volume: 84 Pages: 1131-1138
  • Peer Reviewed
• [Journal Article] DNA double-strand break induction in Ku80-deficient CHO cells following boron neutron capture reaction (2011)
  • Author(s): Kinashi Y, Takahashi S, Kashino G, Okayasu R, Masunaga S, Suzuki M, Ono K
  • Journal Title: Radiat Oncol Volume: 6 Pages: 106-113
  • Peer Reviewed
• [Journal Article] FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ (2011)
  • Author(s): Kondo, N.
  • Journal Title: PLoS ONE Volume: 6 Issue: 6
  • DOI: 10.1371/annotation/c6be24d1-bc23-43b4-ae01-b86dad174069
  • Peer Reviewed
• [Journal Article] Experimental verification of beam characteristics for cyclotron-based epithermal neutron source (C-BENS) (2011)
  • Author(s): Tanaka H, Sakurai Y, Suzuki M, Masunaga S, Mitsumoto T, Fujita K, Kashino G, Kinashi Y, Liu Y, Takada M, Ono K, Maruhashi A
  • Journal Title: Appl Radiat Isot Volume: 69 Pages: 1642-1645
  • Peer Reviewed
• [Journal Article] Evaluation of the in vivo radiosensitizing activity of etanidazole using tumor-bearing chick embryo (2011)
  • Author(s): Abe C, Uto Y, Nakae T, Shinmoto Y, Sano K, Nakata H, Teraoka M, Endo Y, Maezawa H, Masunaga S, Nakata E, Hori H
  • Journal Title: J Radiat Res Volume: 52 Pages: 208-214
  • Peer Reviewed
• [Journal Article] 特集「岐路に立つホウ素中性子捕捉療法」、「医師の立場-放射線治療医の視点から」 (2011)
  • Author(s): 増永慎一郎
  • Journal Title: 月刊「エネルギーレビュー」 Volume: 11月号 Pages: 21-22
  • Peer Reviewed
• [Presentation] 第3回放射線生物学セミナー、「放射線感受性を修飾する内因性及び外因性因子」 (2014)
  • Author(s): 増永慎一郎
  • Organizer: 日本放射線腫瘍学会教育委員会・生物部会主催、第4回放射線生物学セミナー（枚方、大阪）
  • Place of Presentation: 関西医科大学附属枚方病院１３階講堂、枚方、大阪
  • Invited
• [Presentation] 局所腫瘍制御と肺転移抑制能から見たγ線照射時における分割ウォルトマニン投与併用の有用性 (2014)
  • Author(s): 増永慎一郎、田野恵三、櫻井良憲、田中浩基、鈴木実、近藤夏子、楢林正流、渡辺翼、丸橋晃、小野公二
  • Organizer: 第73回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜、横浜
• [Presentation] The dependency of compound biological effectiveness factors on the type and concentration of administered neutron capture agents in BNCT (2013)
  • Author(s): Masunaga S, Tano K., et al
  • Organizer: At the 7th Young Researchers Boron Neutron Capture Therapy Meeting
  • Place of Presentation: Granada, Spain
• [Presentation] Significance of daily fractionated administration of wortmannin combined with γ-ray irradiation in terms of local tumor response and lung metastatic potential (2013)
  • Author(s): Masunaga S, Tano K., et al
  • Organizer: At the 55th Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO)
  • Place of Presentation: Atlanta, Georgia, USA
• [Presentation] Significance of manipulating intratumor hypoxia in terms of local tumor control and pulmonary metastatic potential in boron neutron capture therapy (2013)
  • Author(s): Masunaga S, Sakurai Y, Tanaka H., et al
  • Organizer: Presented at the 2013 Annual Meeting of the American Roentgen Ray Society
  • Place of Presentation: Washington DC, USA
• [Presentation] Significance of manipulating intratumor hypoxia in terms of local tumor control and pulmonary metastatic potential in boron neutron capture therapy. (2013)
  • Author(s): Masunaga S, Sakurai Y, Tanaka H, Suzuki M, Kondo N, Kinashi Y, Maruhashi A and Ono K
  • Organizer: The 2013 Annual Meeting of the American Roentgen Ray Societ
  • Place of Presentation: Washington DC, USA.
  • Invited
• [Presentation] Significance of daily fractionated administration of wortmannin combined with gamma-ray irradiation in terms of local tumor response and lung metastatic potential. (2013)
  • Author(s): Masunaga S, Tano K, Sakurai Y, Tanaka H, Suzuki M, Kondo N, Narabayashi M, Watanabe T, Maruhashi A, Ono K
  • Organizer: the 55th Annual Meeting of The American Society for Therapeutic Radiology and Oncology (ASTRO).
  • Place of Presentation: Atlanta, Georgia, USA.
• [Presentation] The dependency of compound biological effectiveness factors on the type and concentration of administered neutron capture agents in BNCT. (2013)
  • Author(s): Masunaga S, Tano K, Sakurai Y, Tanaka H, Suzuki M, Kondo N, Narabayashi M, Watanabe T, Maruhashi A, Ono K.
  • Organizer: The 7th Young Researchers Boron Neutron Capture Therapy Meeting
  • Place of Presentation: Granada, Spain
• [Presentation] 休止期腫瘍細胞の挙動に及ぼす分割照射の影響について (2013)
  • Author(s): 増永慎一郎 、田野恵三、小野公二
  • Organizer: 次世代がん治療推進専門家養成プラン、シンポジウム～癌治療抵抗性機構とその克服～(Part II)、放射線治療の潮流 ‐Hypofractionationの基礎と臨床－ （東京）
  • Place of Presentation: 東京医科歯科大学、東京
  • Invited
• [Presentation] 中性子捕捉療法（BNCT）における腫瘍内低酸素の意義 (2013)
  • Author(s): 増永慎一郎、田野恵三、櫻井良憲、田中浩基、鈴木実、近藤夏子、楢林正流、渡邉翼、丸橋晃、小野公二
  • Organizer: 第42回放射線による制癌シンポジウム、シンポジウムI：低酸素状態と放射線感受性 （仙台）
  • Place of Presentation: 艮陵会館（東北大学医学部キャンパス前）、仙台
  • Invited
• [Presentation] ピモニダゾール非標識酸素化休止期腫瘍細胞分画における放射線損傷からの回復に対するティラパザミン処置，低温度温熱処置の影響 (2013)
  • Author(s): 増永慎一郎 、田野恵三、鈴木実、近藤夏子、楢林正流、渡邉翼、小野公二
  • Organizer: 日本ハイパーサーミア学会第30回大会 シンポジウム「再発、転移に対する温熱生理」
  • Place of Presentation: 横浜シンポジア（横浜）
  • Invited
• [Presentation] 局所腫瘍制御と肺転移抑制能から見た低酸素細胞毒連続投与と低温度温熱処置併用放射線照射の意義 (2013)
  • Author(s): 増永慎一郎、櫻井良憲、田中浩基、鈴木実、近藤夏子、楢林正流、丸橋晃、小野公二
  • Organizer: 第72回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜、横浜
• [Presentation] γ線、加速炭素イオン線、中性子捕捉反応に対する酸素化休止期腫瘍細胞の放射線感受性解析 (2013)
  • Author(s): 増永慎一郎、櫻井良憲、田中浩基、平山亮一、松本孔貴、鵜沢玲子、鈴木実、近藤夏子、楢林正流、渡邉翼、丸橋晃、小野公二
  • Organizer: 第10回日本中性子捕捉療法学会学術大会
  • Place of Presentation: 岡山大学（津島キャンパス） 創立五十周年記念館、岡山
• [Presentation] ピモニダゾール非標識酸素化休止期腫瘍細胞分画における放射線損傷からの回復をウォルトマニンは効率よく抑制する (2013)
  • Author(s): 増永慎一郎、田野恵三、櫻井良憲、田中浩基、鈴木実、近藤夏子、楢林正流、渡邉翼、木梨友子、丸橋晃、小野公二
  • Organizer: 日本放射線影響学会第56回大会
  • Place of Presentation: ホテルクラウンパレス青森、青森
• [Presentation] 局所腫瘍効果と肺転移抑制能から見た分割ウォルトマニン投与併用γ線照射の有用性 (2013)
  • Author(s): 増永慎一郎、田野恵三、櫻井良憲、田中浩基、鈴木実、近藤夏子、楢林正流、渡邉翼、丸橋晃、小野公二
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: ホテル青森、リンクステーションホール青森
• [Presentation] 局所腫瘍制御と肺転移抑制能から見た低酸素細胞毒(Tirapazamine)の連続投与と低温度温熱処置を併用する放射線照射の有用性について (2013)
  • Author(s): 増永慎一郎、櫻井良憲、田中浩基、鈴木実、近藤夏子、楢林正流、丸橋晃、小野公二
  • Organizer: 第15回癌治療増感研究シンポジウム
  • Place of Presentation: 奈良・猿沢荘
  • Invited
• [Presentation] 第3回放射線生物学セミナー、「放射線感受性を修飾する内因性及び外因性因子」 (2013)
  • Author(s): 増永慎一郎
  • Organizer: 日本放射線腫瘍学会教育委員会・生物部会主催、第3回放射線生物学セミナー
  • Place of Presentation: 東京・東京医科歯科大学
• [Presentation] Radio-sensitivity Of Pimonidazole-unlabeled Intratumor Quiescent Cells To Gamma-rays, Accelerated Carbon Ion Beams And Boron Neutron Capture Reaction (2012)
  • Author(s): Masunaga S, Sakurai Y, Tanaka H., et al
  • Organizer: At the 54th Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO)
  • Place of Presentation: Boston, Massachusetts, USA
• [Presentation] Evaluation of cell survival and micronucleus formation in clamped and non-clamped solid tumors exposed to carbon-ion beams in comparison to X-rays (2012)
  • Author(s): Hirayama R, Uzawa A, Takase N, Koda K, Matsumoto Y, Ozaki M, Noguchi M, Kase Y, Matsufuji N, Koike S, Masunaga S, Ando K, Okayasu R, Furusawa Y
  • Organizer: At the 10th International Symposium on Chromosomal Aberrations
  • Place of Presentation: Amalfi, Italy
• [Presentation] The effect of fractionated carbon-ion beams to tumor metastasis (2012)
  • Author(s): Matsumoto Y, Uzawa A, Hirayama R, Koike S, Koda K, Masunaga S, Ando K and Furusawa Y
  • Organizer: At the 39th Annual Meeting of The European Radiation Research Society
  • Place of Presentation: Vietry sul Mare, Italy
• [Presentation] Significance of employing boron-10 carriers and manipulating intratumor oxygenation status in terms of local tumor response and lung metastatic potential in boron neutron capture therapy (2012)
  • Author(s): Masunaga S, Sakurai Y, Tanaka H., et al
  • Organizer: At the 15th International Congress on Neutron Capture Therapy
  • Place of Presentation: Tsukuba, Japan
• [Presentation] Symthesis and evaluation of cyclic RGD-boron cluster conjugates as a novel ^<10>B-carrier for boron neutron capture therapy (2012)
  • Author(s): Nagasawa H, Kimura S, Masunaga S., et al
  • Organizer: At the 15th International Congress on Neutron Capture Therapy
  • Place of Presentation: Tsukuba, Japan
• [Presentation] Usefulness of combined treatment with continuous tirapazamine administration and mild temperature hyperthermia in gamma-ray irradiation, referring to lung metastatic potential (2012)
  • Author(s): Masunaga S, Sakurai Y, Tanaka H., et al
  • Organizer: At The 11th International Congress of Hyperthermic Oncology (ICHO) & The 29th Japanese Congress of Thermal Medicine (JCTM)
  • Place of Presentation: Hyatt Regenct Hotel Kyoto, Kyoto, Japan
• [Presentation] Impact of employing ^<10>B-carriers and manipulating intratumor hypoxia on local tumor response and lung metastatic potential in boron neutron capture therapy (2012)
  • Author(s): Masunaga S, Sakurai Y, Tanaka H., et al
  • Organizer: At the International Conference on Translational Research in Radio-Oncology and Physics for Health in Europe (ICTR-PHE 2012)
  • Place of Presentation: Geneva, Switzerland
• [Presentation] 局所腫瘍制御と肺転移能抑制の点からみた中性子捕捉療法における腫瘍内酸素化状況修飾の意義 (2012)
  • Author(s): 増永慎一郎、櫻井良憲、田中浩基、鈴木実、近藤夏子、丸橋晃、小野公二
  • Organizer: 第71回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 通常放射線照射および中性子捕捉療法後の局所腫瘍効果と肺転移抑制効果における腫瘍内酸素状況修飾処置併用の意義 (2012)
  • Author(s): 増永慎一郎、松本孔貴、平山亮一、櫻井良憲、田中浩基、鵜澤玲子、鈴木実、近藤夏子、丸橋晃、小野公二
  • Organizer: 第41 回 放射線による制癌シンポジウム-;基礎と臨床の対話-
  • Place of Presentation: 沖縄宜野湾市カルチャーリゾートフェストーネ
  • Invited
• [Presentation] γ線、加速炭素イオン線、中性子捕捉反応に対する酸素化休止期腫瘍細胞の放射線感受性 (2012)
  • Author(s): 増永慎一郎、櫻井良憲、田中浩基、平山亮一、松本孔貴、鵜澤玲子、鈴木実、近藤夏子、楢林正流、小野公二
  • Organizer: 日本放射線影響学会第55回大会
  • Place of Presentation: 東北大学川内北キャンパス（旧教養部）
• [Presentation] γ線、加速炭素イオン線、中性子捕捉反応に対する酸素化休止期腫瘍細胞の感受性解析 (2012)
  • Author(s): 増永慎一郎、櫻井良憲、田中浩基、平山亮一、松本孔貴、鵜澤玲子、鈴木実、近藤夏子、丸橋晃、小野公二
  • Organizer: 日本放射線腫瘍学会第25回学術大会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] Usefulness of combined treatment with continuous tirapazamine administration and mild temperature hyperthermia in gamma-ray irradiation, referring to lung metastatic potential. (2012)
  • Author(s): Masunaga S, Sakurai Y, Tanaka H, Suzuki M, Kondo N, Narabayashi M, Maruhashi A, Ono K.
  • Organizer: The 11th International Congress of Hyperthermic Oncology and the 29th Japanese Congress of Thermal Medicine
  • Place of Presentation: Hyatt Regency Kyoto, Japan
• [Presentation] Significance of employing boron-10 carriers and manipulating intratumor oxygenation status in terms of local tumor response and lung metastatic potential in boron neutron capture therapy. (2012)
  • Author(s): Masunaga S, Sakurai Y, Tanaka H, Suzuki M, Kondo N, Narabayashi M, Maruhashi A and Ono K.
  • Organizer: The 15th International Congress on Neutron Capture Therapy
  • Place of Presentation: Tsukuba International Congress Center
• [Presentation] Radio-sensitivity Of Pimonidazole-unlabeled Intratumor Quiescent Cells To Gamma-rays, Accelerated Carbon Ion Beams And Boron Neutron Capture Reaction (2012)
  • Author(s): S. Masunaga, Y. Sakurai, H. Tanaka, R. Hirayama, Y. Matsumoto, A. Uzawa, M. Suzuki, N. Kondo, A. Maruhashi, K. Ono
  • Organizer: The 54th Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO)
  • Place of Presentation: Boston Convention & Exhibition Center, MA, USA
• [Presentation] Impact of employing 10B-carriers and manipulating intratumor hypoxia on local tumor response and lung metastatic potential in boron neutron capture therapy (2012)
  • Author(s): Masunaga S, Sakurai Y, Tanaka H, Suzuki M, Kondo N, Maruhashi A, Ono K
  • Organizer: the International Conference on Translational Research in Radio-Oncology and Physics for Health in Europe (ICTR-PHE
  • Place of Presentation: Centre International de Conferences Geneve, Geneva
• [Presentation] The characteristics of ^<10>B distribution in solid tumors in vivo following BSH or BP A administration, based on the responses of intratumor total and quiescent cell populations (2011)
  • Author(s): Masunaga S, Sakurai Y, Tanaka H., et al
  • Organizer: At the 6th Young Researchers BNCT Meeting
  • Place of Presentation: Hsinchu City , Taiwan (R.O.C.)
• [Presentation] Significance of Using a ^<10>B-Carrier and Manipulating Intratumor Hypoxia on Local Tumor Response and Lung Metastatic Potential in Boron Neutron Capture Therapy (2011)
  • Author(s): Masunaga S, Sakurai Y, Tanaka H., et al
  • Organizer: At the 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO)
  • Place of Presentation: Miami Beach, FLA, USA
• [Presentation] Significance of Employing a ^<10>B-Carrier and Manipulating Intratumor Hypoxia in terms of Local Tumor Response and Lung Metastatic Potential in Boron Neutron Capture Therapy (2011)
  • Author(s): Masunaga S, Sakurai Y, Tanaka H., et al
  • Organizer: At the 14th International Congress of Radiation Research (ICRR)
  • Place of Presentation: Warsaw, Poland
• [Presentation] Significance of Employing a 10B-Carrier and Manipulating Intratumor Hypoxia in terms of Local Tumor Response and Lung Metastatic Potential in Boron Neutron Capture Therapy (2011)
  • Author(s): Masunaga S, Sakurai Y, Tanaka H, Suzuki M, Kondo N, Maruhashi A, Ono K
  • Organizer: the 14th International Congress of Radiation Research (ICRR)
  • Place of Presentation: The Palace of Culture and Science, Warsaw, Poland
• [Presentation] Significance of Using a 10B-Carrier and Manipulating Intratumor Hypoxia on Local Tumor Response and Lung Metastatic Potential in Boron Neutron Capture Therapy (2011)
  • Author(s): Masunaga S, Sakurai Y, Tanaka H, Suzuki M, Kondo N, Maruhashi A, Ono K
  • Organizer: the 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO)
  • Place of Presentation: Miami Beach Convention Center, Miami Beach, Florida, USA
• [Presentation] The Characteristics of 10B Distribution in Solid Tumors in Vivo Following BSH or BPA Administration, Referring to the Responses of Intratumor Total and Quiescent Cell Populations and the Impact on Pulmonary Metastatic Potential (2011)
  • Author(s): Masunaga S, Sakurai Y, Tanaka H, Suzuki M, Kondo N, Maruhashi A, Ono K
  • Organizer: the 6th Young Researchers Boron Neutron Capture Therapy Meeting
  • Place of Presentation: National Tsing Hua University, Hsinchu, Taiwan(Invited)
• [Presentation] 固形腫瘍へのアバスチン(Bevacizumab)処理による急性低酸素細胞分画の低下と肺転移抑制効果 (2011)
  • Author(s): 増永慎一郎、劉勇、田中浩基、櫻井良憲、鈴木実、菓子野元郎、木梨友子、近藤夏子、丸橋晃、小野公二
  • Organizer: 第70回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] 原子炉熱外中性子線ビーム照射中のBNCT施行患者血中硼素-10濃度に影響し得る因子の予備的解析 (2011)
  • Author(s): 増永慎一郎、鈴木実、櫻井良憲、田中浩基、近藤夏子、木梨友子、丸橋晃、小野公二
  • Organizer: 第8回日本中性子捕捉療法学会学術大会
  • Place of Presentation: 徳鳥大学長井記念ホール(徳鳥県)
• [Presentation] 中性子捕捉療法における低温度温熟処置など腫瘍内酸素化状況修飾の意義について (2011)
  • Author(s): 増永慎一郎、櫻井良憲、田中浩基、鈴木実、近藤夏子、丸橋晃、小野公二
  • Organizer: 日本ハイパーサーミア学会第28回大会(シンポジウム6-5)
  • Place of Presentation: ウィンクあいち(愛知県産業労働センター)、(愛知県)(招聘講演)
• [Presentation] 酸素標的・増感放射線療法KORTUCの基礎と臨床、放射線治療効果の修飾因子について (2011)
  • Author(s): 増永慎一郎
  • Organizer: 日本放射線腫瘍学会第24回学術大会、シンポジウム(9)(S9-1)
  • Place of Presentation: 神戸ポートピアホテル(兵庫県)(招聘講演)
• [Presentation] 局所腫瘍内低酸素領域の修飾が及ぼす遠隔肺転移能への影響-局所腫瘍制御と遠隔転移能抑制の同時達成に向けて (2011)
  • Author(s): 増永慎一郎、松本孔貴、平山亮一、櫻井良憲、田中浩基、鈴木実、近藤夏子、丸橋晃、小野公二
  • Organizer: 日本放射線影響学会第54回大会、ワークショップ10(W10-4)
  • Place of Presentation: 神戸商工会議所会館(兵庫県)(招聘講演)
• [Book] 放射線生物学, 第2章 放射線療法の方法, 1. 放射線療法の基礎, 「チームで取り組む乳がん放射線療法」 (2013)
  • Author(s): 増永慎一郎
  • Publisher: (株) メディカル教育研究社
• [Book] 通常放射線照射および中性子捕捉療法後の局所腫瘍効果と肺転移抑制効果における腫瘍内酸素状況修飾処置併用の意義, 癌の臨床 (Jpn J Cancer Clin) (2013)
  • Author(s): 増永慎一郎, 松本孔貴, 平山亮一, 他 計11名
  • Publisher: 篠原出版新社
• [Book] 放射線治療に資するがん転移研究-オーバービュ-, 癌の臨床(Jpn J Cancer Clin) (2013)
  • Author(s): 松本孔貴, 増永慎一郎, 皆巳和賢, 他 計8名
  • Publisher: 篠原出版新社
• [Book] 放射線生物学、第２章放射線療法の方法、１．放射線療法の基礎、「チームで取り組む乳がん放射線療法」 (2013)
  • Author(s): 増永慎一郎
  • Publisher: （株）メディカル教育研究社
• [Book] 放射線生物学、第２章放射線療法の方法、１．放射線療法の基礎、「チームで取り組む乳がんの放射線療法」 (2013)
  • Author(s): 増永慎一郎
  • Total Pages: 500
  • Publisher: （株）メディカル教育研究社
• [Book] 通常放射線照射および中性子捕捉療法後の局所腫瘍効果と肺転移抑制効果における腫瘍内酸素状況修飾処置併用の意義 (2013)
  • Author(s): 増永慎一郎、松本孔貴、平山亮一、櫻井良憲、田中浩基、鵜澤玲子、鈴木 実、近藤夏子、楢林正流、丸橋 晃、小野公二
  • Total Pages: 120
  • Publisher: 篠原新社
• [Book] がん細胞と正常組織の放射線応答, 「臨床放射線腫瘍学」 最新知見に基づいた放射線治療の実践 (2012)
  • Author(s): 増永慎一郎
  • Publisher: (株) 南江堂
• [Book] がん細胞と正常組織の放射線応答、「臨床放射線腫瘍学」 (2012)
  • Author(s): 増永慎一郎
  • Total Pages: 534
  • Publisher: 南江堂
• [Book] 特集 「岐路に立つホウ素中性子捕捉療法」, 「医師の立場-放射線治療医の視点から」, 月刊 「エネルギーレビュー」 (2011)
  • Author(s): 増永慎一郎
  • Publisher: エネルギーレビューセンター
• [Book] 放射線治療効果の修飾因子について,癌の臨床 (Jpn J Cancer Clin) (2011)
  • Author(s): 増永慎一郎, 小川恭弘
  • Publisher: 篠原出版新社
• [Book] 「BNCT基礎から臨床応用まで」-BNCTを用いて治療にかかわる人のためのテキスト-中性子捕捉療法を理解するための生物学の基礎 (2011)
  • Author(s): 増永慎一郎
  • Publisher: 財団法人医用原子力技術研究振興財団
• [Book] 「BNCT基礎から臨床応用まで」-BNCTを用いて治療にかかわる人のためのテキスト-中性子捕捉療法による抗腫瘍効果 (2011)
  • Author(s): 増永慎一郎
  • Publisher: 財団法人医用原子力技術研究振興財団