Research Project
Grant-in-Aid for Scientific Research (B)
Recently it is highlighted that inflammation is closely linked to tumor progression. In this study we demonstrate that IL-1 promotes tumor angiogenesis and lymphangiogenesis through infiltration of tumor supporting macrophages expressing anigogenic and lymphangiogenic factors, resulting in lymph node metastasis of lung cancer cells by comparing highly metastatic human lung cancer cell line expressing higher IL-1alpha with its low metastatic counterpart expressing lower IL-1alpha. Furthermore, we also demonstrate that IL-1/IL-1R-targeted drug significantly suppresses tumor angiogenesis, lymphangiogenesis, and lymph node metastasis. IL-1/IL-1R may thus play crucial roles in malignant progression by lung cancer cells, and the therapeutic efficacy of IL-1R-targeted drugs may lead to an alternative novel strategy to treat lymph node metastasis.
All 2014 2013 2012 2011 Other
All Journal Article (25 results) (of which Peer Reviewed: 25 results) Presentation (45 results) Book (2 results) Remarks (3 results)
PLoS ONE
Volume: (in press)
10.1371/journal.pone.0099568
Volume: 印刷中 Pages: 印刷中
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J Biol Chem
Volume: 288 Pages: 25025-25037
10.1074/jbc.M113.472068
Cancer Res
Volume: 73 Pages: 6243-6253
10.1158/0008-5472.CAN-12-4502
Biol. Pharm. Bull
Volume: 36 Pages: 152-157
10.1248/bpb.b12-00871
Biol. Pharm. Bull.
10.1248/bpb.b12-00871.
J Biol Chem.
10.1074/jbc.M113.472068.
Volume: 7 Pages: e41312
10.1371/journal.pone.0041312
Journal of Thoracic Oncology
Volume: 7 Pages: 779-789
10.1097/JTO.0b013e31824c92b4
International Journal of Cancer
Volume: 131 Pages: 310-321
10.1002/ijc.26356
Int. J. Cancer
10.1002/ijc.26356.
J. Thorac. Oncol.
10.1097/JTO.0b013e31824c92b4.
10.1371/journal.pone.0041312.
Molecular Cancer Therapeutics
Volume: 11 Pages: 204-213
10.1158/1535-7163
Volume: (In press)
Nature Medicine
Volume: 18 Pages: 74-82
10.1038/nm.2577
The American Journal of Pathology
Volume: 179 Pages: 1157-1170
10.1016/j.ajpath.2011.05.034
Cancer Letters
Volume: 310 Pages: 25-34
10.1016/j.canlet.2011.05.034
Experimental and Therapeutic Medicine
Volume: 2 Pages: 471-479
10.3892/etm.2011.222
Int J Oncol
Volume: 38 Pages: 493-501
10.3892/ijo.2010.856
Lung Cancer
Volume: 73 Pages: 361-365
10.1016/j.lungcan.2011.01.008
Volume: 6 Pages: 122-127
10.1097/JTO.0b013e31822eeba2
http://shuyo.phar.kyushu-u.ac.jp/