Development of a tailor-made molecular targeted oncologic diagnostic imaging using a newly-developed amino acid PET tracer.
Project/Area Number |
23300360
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Tumor diagnosis
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Research Institution | Research Institute, Shiga Medical Center |
Principal Investigator |
HIGASHI Tatsuya 滋賀県立成人病センター(研究所), その他部局等, その他 (50324629)
|
Co-Investigator(Kenkyū-buntansha) |
NISHII Ryuichi 宮崎大学, 医学部, 講師 (60463212)
KAGAWA Shinya 滋賀県立成人病センター(研究所), 主任研究員 (10393191)
OOMOMO Yoshiro 大阪薬科大学, 薬学部, 准教授 (70183241)
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Project Period (FY) |
2011-11-18 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
|
Keywords | 癌 / 放射線画像診断 / 薬学 / テーラーメード治療 / 分子標的 / テーラーメイド医療 / 分子イメージング / PET / アミノ酸輸送システム / PET検査 / 酢酸イメージング / 肝臓腫瘍 / 前立腺腫瘍 |
Research Abstract |
We developed and had a success of the radio-synthesis method of [18F]NMeFAMP and the results of the synthesis was quite excellent with yield evaluation about 20%, synthesis time about 90 min, radiochemical purity > 99.9%. However, we could not move ahead to quality control test, acute toxicity test, etc. On the other hand, we had successful results in the radio-synthesis methods of [18F]FACE using newly-introduced solid phase extraction techniques, two-pot distillation and one-pot distillation methods. With these techniques, we can provide [18F]FACE radio-synthesis methods with higher quality, cheaper, and more simple process, as compared to the traditional on-column hydrolysis method. After the approval of our ethical committee, we performed a human PET study with liver tumor patients using [18F]FACE and [18F]FDG, and the results were published by a well-known medical journal, Annals of Nuclear Medicine.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Assessment of [18F]-fluoroacetate PET/CT as a tumor-imaging modality : preclinical study in healthy volunteers and clinical evaluation in patients with liver tumor2014
Author(s)
Takemoto K, Hatano E, Nishii R, Kagawa S, Kishibe Y, Takahashi M, Yamauchi H, Matsumura K, Zaima M, Toriguchi K, Tanabe K, Kitamura K, Seo S, Taura K, Endo K, Uemoto S, Higashi T
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Journal Title
Ann Nucl Med
Volume: (Epub ahead of print)
Related Report
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[Journal Article] Assessment of [18F]-fluoroacetate PET/CT as a tumor-imaging modality: preclinical study in healthy volunteers and clinical evaluation in patients with liver tumor.2014
Author(s)
① Takemoto K, Hatano E, Nishii R, Kagawa S, Kishibe Y, Takahashi M, Yamauchi H, Matsumura K, Zaima M, Toriguchi K, Tanabe K, Kitamura K, Seo S, Taura K, Endo K, Uemoto S, Higashi T.
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Journal Title
Annals of Nuclear Medicine
Volume: 28
Issue: 4
Pages: 371-380
DOI
Related Report
Peer Reviewed
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[Journal Article] Diagnostic usefulness of an amino acid tracer, α-[N-methyl- ^11C]-methylaminoisobutyric acid ( ^<11>C-MeAIB), in the PET diagnosis of chest malignancies2013
Author(s)
Nishii R, Higashi T, Kagawa S, Kishibe Y, Takahashi M, Yamauchi H, Motoyama H, Kawakami K, Nakaoku T, Nohara J, Okamura M, Watanabe T, Nakatani K, Nagamachi S, Tamura S, Kawai K, Kobayashi M
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Journal Title
Ann Nucl Med
Volume: 27(9)
Issue: 9
Pages: 808-21
DOI
Related Report
Peer Reviewed
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[Presentation] 新しい固相抽出技術を用いた[^<18>F]Fluoroacetate ([^<18>F]FACE) 合成法の検討2013
Author(s)
加川信也, 西井龍一, 東達也, 山内 浩, 高橋和弘, 水間広, 尾上浩隆, 竹本研史, 波多野悦郎, 川井恵一
Organizer
第53回日本核医学会学術総会
Place of Presentation
福岡国際会議場, 博多, 福岡
Year and Date
2013-11-09
Related Report
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[Presentation] Oncologic diagnosis of liver tumors using [^<18>F]-fluoroacetate PET/CT as compared to [^<18>F]-fluorodeoxyglucose PET/CT2013
Author(s)
Tatsuya Higashi, Ryuichi Nishii, Shinya Kagawa, Masaaki Takahashi, Yoshihiko Kishibe, Hiroshi Yamauchi, Kazuyoshi Matsumura, Masazumi Zaima, Kenji Takemoto, Etsuro Hatano
Organizer
Initial experience. EANM2013. Annual Congress of the European Association of Nuclear Medicine
Place of Presentation
Lyon, France
Year and Date
2013-10-19
Related Report
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[Presentation] [^<18>F]Fluoroacetate ([18F]FACE) 臨床研究に向けて2013
Author(s)
加川 信也, 矢倉 栄幸, 西井 龍一, 東 達也, 岸辺 喜彦, 高橋 昌章, 山内 浩, 水川 陽介, 竹本 研史, 波多野 悦郎, 高橋 和弘, 水間 広, 尾上 浩隆, 川井 恵一
Organizer
PETサマーセミナー2013
Place of Presentation
金沢日航ホテル, 金沢, 石川
Year and Date
2013-08-23
Related Report
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[Presentation] Assessment of [^<18>F]-Fluoroacetate PET/CT as a tumor-imaging modality : Comparison with [^<18>F]-FDG in patients with liver tumor and in healthy volunteers2013
Author(s)
Tatsuya Higashi, Ryuichi Nishii, Shinya Kagawa, Masaaki Takahashi, Yoshihiko Kishibe, Hiroshi Yamauchi, Kazuyoshi Matsumura, Masazumi Zaima, Kenji Takemoto, Etsuro Hatano
Organizer
60th Annual Meeting of Society of Nuclear Medicine
Place of Presentation
Vancouver, Canada
Year and Date
2013-06-08
Related Report
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[Presentation] Novel approach for solid-phase radiosynthesis of ^<18>F-Fluoroacetate : Comparison between one-pot and two-pot distillation procedure2013
Author(s)
Shinya Kagawa, Ryuichi Nishii, Tatsuya Higashi, Hiroshi Yamauchi, Kenji Takemoto, Akiko Tachibana, Kazuhiro Takahashi, Hiroshi Mizuma, Hirotaka Onoe, Keiichi Kawai
Organizer
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) 60th Annual Meeting
Place of Presentation
VANCOUVER, BC, CANADA
Related Report
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[Presentation] Radiosynthesis of [^<18>F]Fluoroacetate by a one-pot distillation procedure : a novel approach of the solid-phase synthesis2013
Author(s)
Shinya Kagawa, Ryuichi Nishii, Tatsuya Higashi, Hiroshi Yamauchi, Kenji Takemoto, Etsuro Hatano, Akiko Tachibana, Kazuhiro Takahashi, Hiroshi Mizuma, Hirotaka Onoe, Shigeki Nagamachi, Keiichi Kawai, Shozo Tamura
Organizer
The 20th International Symposium on Radiopharmaceutical Sciences (ISRS)
Place of Presentation
ICC JEJU, Jeju, KOREA
Related Report
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[Presentation] Oncologic diagnosis of liver tumors using [18F]-fluoroacetate PET/CT as compared to [18F]-fluorodeoxyglucose PET/CT. Initial experience.2013
Author(s)
② Tatsuya Higashi, Ryuichi Nishii, Shinya Kagawa, Masaaki Takahashi, Yoshihiko Kishibe, Hiroshi Yamauchi, Kazuyoshi Matsumura, Masazumi Zaima, Kenji Takemoto, Etsuro Hatano.
Organizer
EANM2013. Annual Congress of the European Association of Nuclear Medicine.
Place of Presentation
Lyon, France
Related Report
-
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[Presentation] Assessment of [18F]-Fluoroacetate PET/CT as a tumor-imaging modality: Comparison with [18F]-FDG in patients with liver tumor and in healthy volunteers.2013
Author(s)
④ Tatsuya Higashi, Ryuichi Nishii, Shinya Kagawa, Masaaki Takahashi, Yoshihiko Kishibe, Hiroshi Yamauchi, Kazuyoshi Matsumura, Masazumi Zaima, Kenji Takemoto, Etsuro Hatano.
Organizer
60th Annual Meeting of Society of Nuclear Medicine.
Place of Presentation
Vancouver, Canada.
Related Report
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[Presentation] Novel approach for solid-phase radiosynthesis of 18F-Fluoroacetate: Comparison between one-pot and two-pot distillation procedure.2013
Author(s)
⑤ Shinya Kagawa, Ryuichi Nishii, Tatsuya Higashi, Hiroshi Yamauchi, Kenji Takemoto, Akiko Tachibana, Kazuhiro Takahashi, Hiroshi Mizuma, Hirotaka Onoe, Keiichi Kawai.
Organizer
60th Annual Meeting of Society of Nuclear Medicine.
Place of Presentation
Vancouver, Canada.
Related Report
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[Presentation] Radiosynthesis of [18F]Fluoroacetate by a one-pot distillation procedure: a novel approach of the solid-phase synthesis.2013
Author(s)
⑥ Shinya Kagawa, Ryuichi Nishii, Tatsuya Higashi, Hiroshi Yamauchi, Kenji Takemoto, Etsuro Hatano, Akiko Tachibana, Kazuhiro Takahashi, Hiroshi Mizuma, Hirotaka Onoe, Shigeki Nagamachi, Keiichi Kawai, Shozo Tamura.
Organizer
The 20th International Symposium on Radiopharmaceutical Sciences (ISRS).
Place of Presentation
Jeju, KOREA
Related Report
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[Presentation] Radiosynthesis of [^<18>F]Fluoroacetate : Comparison between on-column hydrolysis method and two-pot distillation procedure using a cassette-type multipurpose automatic synthesizer module2012
Author(s)
Shinya Kagawa, Ryuichi Nishii, Tatsuya Higashi, Hiroyo Araki, Hiroyuki Okudaira, Tomoya Uehara, Masato Kobayashi, Mitsuyoshi Yoshimoto, Yasushi Arano, Keiichi Kawai
Organizer
European Association of Nuclear Medicine ( EANM ) Congress 2012
Place of Presentation
Milan, Italia
Year and Date
2012-10-30
Related Report
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[Presentation] [^<18>F]Fluoroacetateの合成法の開発 : オンカラム加水分解法とtwo-pot蒸留法の比較2012
Author(s)
加川信也, 西井龍一, 東達也, 岸辺喜彦, 高橋昌章, 高橋和弘, 水間広, 尾上浩隆, 竹本研史, 川井恵一, 山内浩
Organizer
第52回日本核医学会学術総会
Place of Presentation
ロイトン札幌, 札幌市, 北海道
Year and Date
2012-10-12
Related Report
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[Presentation] アミノ酸ポジトロン製剤MeAIBによる前立腺癌PET診断-FDG, MRI との比較検討-2012
Author(s)
東達也, 西井龍一, 加川信也, 岸辺喜彦, 高橋昌章, 山内浩, 石戸谷哲, 植村祐一, 牛田博, 大西裕之
Organizer
第52回日本核医学会 学術総会
Place of Presentation
ロイトン札幌, 札幌市, 北海道
Year and Date
2012-10-11
Related Report
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[Presentation] Assessment of efficacy of [^<11>C]-MeAIB PET/CT as a biomarker of the system A amino acid transport : Comparison with [^<18>F]-FDG and MRI in the patients with prostate cancer2012
Author(s)
Tatsuya Higashi, Ryuichi Nishii, Shinya Kagawa, Masaaki Takahashi, Yoshihiko Kishibe, Hiroshi Yamauchi, Satoshi Ishitoya, Hiroshi Ushida, Yuichi Uemura, Hiroyuki Oonishi, Keiichi Kawai, Masato Kobayashi
Organizer
59th Annual Meeting of Society of Nuclear Medicine
Place of Presentation
Miami, Florida, USA
Year and Date
2012-06-09
Related Report
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[Presentation] 臨床使用に向けた[^<18>F]Fluoroacetate ([^<18>F]FACE )製造法の検討2012
Author(s)
加川信也, 矢倉栄幸, 西井龍一, 東達也, 山内浩, 水川陽介, 竹本研史, 波多野悦郎, 高橋和弘, 水間広, 尾上浩隆, 長町茂樹, 川井恵一, 田村正三
Organizer
第七回日本分子イメージング学会
Place of Presentation
アクトシティ浜松, 浜松, 静岡
Related Report
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[Presentation] 新規アミノ酸ポジトロン製剤 MeAIB による前立腺癌 PET 診断 -FDG, MRI との比較検討による中間報告 -2011
Author(s)
東達也, 加川信也, 岸辺喜彦, 高橋昌章, 山内浩, 石戸谷哲, 植村祐一, 大西裕之, 南俊介, 西井龍一, 川井恵一
Organizer
第51回日本核医学会学術総会
Place of Presentation
つくば国際会議場, つくば, 茨城
Year and Date
2011-10-28
Related Report
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[Presentation] PET腫瘍診断薬 [^<18>F]Fluoroacetate の合成基礎検討2011
Author(s)
加川信也, 西井龍一, 東達也, 岸辺喜彦, 高橋昌章, 山内浩, 竹本研史, 波多野悦郎, 長町茂樹, 川井恵一, 田村正三
Organizer
第51回日本核医学会学術総会
Place of Presentation
つくば国際会議場, つくば, 茨城
Year and Date
2011-10-28
Related Report
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[Presentation] F-18フルオロ酢酸のヒト肝細胞における集積検討2011
Author(s)
加川信也, 西井龍一, 竹本研史, 東達也, 波多野悦郎, 水間広, 尾上浩隆, 長町茂樹, 川井恵一, 田村正三, Juri G Gerovani
Organizer
第六回日本分子イメージング学会
Place of Presentation
神戸国際会議場, 兵庫
Year and Date
2011-05-26
Related Report
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