Realizing the induction heating cancer therapy by developing new iron nano particle and combination of tumor penetrating peptide (iRGD).
| Project/Area Number |
23300362
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical oncology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
ODA Tatsuya 筑波大学, 医学医療系, 教授 (20282353)
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| Co-Investigator(Kenkyū-buntansha) |
YANAGIHARA Hideto 筑波大学, 数理物質系, 准教授 (50302386)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2011: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | 電磁誘導加熱 / 癌焼灼治療 / 磁性ナノ粒子 / がん治療 / 腫瘍浸透ペプチド / ブロックポリマー / がん / ナノ粒子 / ペプチド / マクロファージ |
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| Outline of Final Research Achievements |
The present research aimed to realize the induction heating cancer therapy, that involve delivers magnetic nano-particles to cancer nodules and eradicate cancer by heat using irradiation of alternating current magnetic field. For this purpose, iron nano particle with high heat productive power more than 500 W/g was indispensable, which was not available at the project start time, and we originally developed surface-modified iron nanoparticle (DINP). The successful production of this new iron nanoparticle were subjected to application of international patent. The surface modification of DINP by block-polymer PEG did not confer sufficient stealth effect which aimed to escape from capture by macrophage and Kupffer cells. The enhanced delivery of DINP by co-addministration of tumor specific penetrating peptide (iRGD) were also unsuccessful. Instead, we directly injected DINP into mouse xenograft and obtained complete eradication by induction heating.
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Report
(5 results)
Research Products
(24 results)
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[Presentation] Electromanetic thermoablation for refractory solid cancer using newly developed magnetic nanoparticles2014
Author(s)
Miyamoto R, Oda T, Hashimoto S, Yamada K, Enomoto T, Akashi Y, Ohara K, Asai K, Nakao S, Horiuchi A, Seki A, Kishimoto M, Yanagihara H, Kita E, Nagasaki Y, Ohkohchi N.
Organizer
つくば医工連携フォーラム2014
Place of Presentation
つくば国際会議場（つくば市）
Related Report
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[Presentation] Electromagnetic thermoablation for refrractory soild cancer using new magnetic nanoparticles2013
Author(s)
Miyamoto R, Oda T, Hashimoto S, Yamada K, Enomoto T, Ohara Y, Akashi Y, Asai K, Kishimoto M, Yanagihara H, Kita E, Nagasaki Y, Ohkohchi N.
Organizer
Tsukuba International Conference on Materials Science
Place of Presentation
つくば国際会議場（つくば市）
Related Report
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