Delivery system responding to the abnormal G protein-coupled receptor signaling for diagnosis and treatment of cardiovascular diseases
| Project/Area Number |
23310085
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Nanomaterials/Nanobioscience
|
|---|
| Research Institution | National Cardiovascular Center Research Institute |
|---|
Principal Investigator |
KANG JEONG-HUN 独立行政法人国立循環器病研究センター, 研究所, 室長 (50423512)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Atsushi 独立行政法人国立循環器病研究センター研究所, 研究員 (50572666)
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
|---|
| Keywords | Ｇタンパク質共役受容体 / プロテインキナーゼ / 細胞内シグナル / ナノ・バイオサイエンス / 循環器疾患 / 薬物送達 / ナノバイオサイエンス / Gタンパク質共役受容体 |
|---|
| Research Abstract |
The purpose of this study was to develop the delivery system of therapeutic molecules responding to the abnormal G protein-coupled receptor signaling for diagnosis and treatment of cardiovascular disease. Novel peptide substrates with high affinity for abnormal cellular signals were identified. Delivery system consisted of hydrophilic neutral polymer as the main chain and peptide substrates as side chains. When the system/gene complex was transfected into cells, gene expression increased in abnormal cells overexpressing target signals, but very low expression was found in normal cell.
|
Report
(4 results)
Research Products
(27 results)
