Emerging pathophysiological roles of ganglioside GM3
| Project/Area Number |
23370064
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
UEMURA Satoshi 青山学院大学, 理工学部, 助教 (10399975)
NAGAFUKU Masakazu 東北薬科大学, 薬学部, 助教 (20399976)
GO Shinji 東北薬科大学, 薬学部, 助教 (10458218)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | スフィンゴ等脂質 / ガングリオシド / 免疫シナプス / ラフト / CD4+ T細胞 / CD8+ T細胞 / アレルギー治療 / 喘息治療 / スフィンゴ糖脂質 / メタボリックシンドローム / マクロファージ / 内臓脂肪 / インスリン抵抗性 / 慢性炎症 / 視床下部 / 過食 / KKAyマウス / T細胞 / アレルギー / 喘息 |
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| Research Abstract |
We have found that CD8T cells express very high levels of o-series gangliosides, but on the other hand, CD4T cells preferably express a-series gangliosides. In the TCR dependent activation, CD4T cells selectively require a-series gangliosides, but CD8T cells do require only o-series gangliosides but not a-series gangliosides. Ganglioside GM3 synthase-deficient mice lacking a-series gangliosides neither exhibited the TCR-dependent activation of CD4T nor developed ovalbumin-induced allergic airway inflammation. These findings imply that the distinct expression pattern of ganglioside species in CD4T and CD8T cells define the immune function of each T cell subset.
We also propose a working hypothesis =metabolic disorders, such as type2 diabetes, are membrane microdomain disorders caused by aberrant expression of gangliosides=.
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Report
(4 results)
Research Products
(67 results)
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[Journal Article] CD4 and CD8 T cells require different membrane gangliosides for activation2012
Author(s)
Nagafuku M, Okuyama K, Onimaru Y, Suzuki A, Odagiri Y, Yamashita T, Iwasaki K, Fujiwara M, Takayanagi M, Ohno I, Inokuchi J
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Journal Title
Proc Natl Acad Sci U S A
Volume: 109
Issue: 6
DOI
Related Report
Peer Reviewed
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