| Budget Amount *help |
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2011: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Research Abstract |
We found that corepressor Ski binds to TRIM27, and that TRIM27 contributes to deubiquitination via forming a complex with USP7. It was found that TRIM27 enters into the nucleus in response to poly(I-C) stimulation, suggesting that Ski ubiquitination may be regulated by TRIM27 in response to specific signaling.
In knockout mice of transcriptional adaptor Shn-2, T cell differentiation in thymus is blocked. It was found that Shn-2 is modified by O-GlcNAc at several sites which modulates nuclear entry of Shn-2. It was demonstrated that Shn-2 is localized on the T-cell receptor beta gene locus, and modulated allelic exclusion.
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