Characterization of the centrosomal kinases that regulate chromosome instability in cancer cells.

• Project/Area Number: 23370086
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cell biology
• Research Institution: Osaka University
• Principal Investigator: NOJIMA HIROSHI 大阪大学, 微生物病研究所, 教授 (30156195)
• Co-Investigator(Renkei-kenkyūsha): YABUTA Norikazu 大阪大学, 微生物病研究所, 准教授 (10343245) ; OKUZAKI Daisuke 大阪大学, 微生物病研究所, 助教 (00346131) ; NAITO Yoko 大阪大学, 微生物病研究所, 特任研究員 (10553026)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000); Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
• Keywords: 染色体不安定性 / 中心体 / キナーゼ / M期チェックポイント / Lats / GAK / 細胞周期 / Cyclin G / リン酸化 / PP2A

Research Abstract

Tumor malignancy promotes cell invasion and metastasis, which is one of the factors that hamper effective cancer therapy. Tumor malignancy means that cancer cells frequently cause missegregation of chromosomes on every cell division to generate two daughter cells with distinct chromosome quantity; this cancer specific feature is called "chromosomal instability". In this study, we show that the centrosomal kinases, Lats1/2 and GAK, form three novel signaling pathways and regulate the stability of chromosomes: they are Aurora-A-Lats1/2-Aurora-B (ALB) and Chk1-Lats2-14-3-3-P-body (CLP) pathways for Lats1/2 and GAK-PP2A-B'gamma-Chk2/Condensin II (GBC) pathway for GAK. To realize efficient analysis, we generated knockout mice lacking Lats1, Lats2, GAK, Cyclin G1 and/or Cyclin G2 genes, and Lats2-defective cancer cells using TALEN/Crispr_Cas systems.

Research Products

• [Journal Article] A functional interaction between Hippo-Y AP signalling and FoxO1 mediates the oxidative stress response (2014)
  • Author(s): Shao D, Zhai P, Del Re DP, Sciarretta S, Y abuta N, Nojima H, Lim DS, Pan D, Sadoshima J
  • Journal Title: Nat. Commun Volume: 5 Issue: 1 Pages: 3315-3315
  • DOI: 10.1038/ncomms4315
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of genes causing hypertension and stroke in spontaneously hypertensive rats : gene expression profiles in the brain (2014)
  • Author(s): Yoshida M, Watanabe Y, Yamanishi K, Yamashita A, Yamamoto H, Okuzaki D, Shimada K, Nojima H, Yasunaga T, Okamura H, Matsunaga H, Yamanishi H
  • Journal Title: Int. J. Mol. Med Volume: 33 Issue: 4 Pages: 887-896
  • DOI: 10.3892/ijmm.2014.1631
  • Peer Reviewed
• [Journal Article] CAWS administration increases the expression of interferon γ and complement factors that lead to severe vasculitis in DBA/2 mice. (2013)
  • Author(s): Noriko Nagi-Miura, Daisuke Okuzaki, Kosuke Torigata, minami A Sakurai, Akihiko Ito, Naohito Ohno, Hiroshi Nojiva
  • Journal Title: BMC Immunology Volume: 14 Issue: 1 Pages: 44-44
  • DOI: 10.1186/1471-2172-14-44
  • Peer Reviewed
• [Journal Article] Ficolin-1 is up-regulated in leukocytes and glomeruli from microscopic polyangiitis patients (2013)
  • Author(s): Muso E, Okuzaki D, Kobayashi S, Iwasaki Y, Sakurai MA, Ito A, Nojima H
  • Journal Title: Autoimmunity Volume: 46 Issue: 8 Pages: 513-524
  • DOI: 10.3109/08916934.2013.822073
  • Peer Reviewed
• [Journal Article] Lats2 phosphorylates p21/CDENlA after UV irradiation and regulates apopiosis. (2013)
  • Author(s): Suzuki H. Yabuta N. Okada N. Torigata K. Aylon Y Oren M. Noiima H.
  • Journal Title: J Cell Sci. Volume: 126 Issue: 19 Pages: 4358-68
  • DOI: 10.1242/jcs.125815
  • Peer Reviewed
• [Journal Article] Recruitment of cyclin G2 to promyelocytic leukemia nuclear bodies promotes dephosphorylation of γH2AX following treatment with ionizing radiation (2013)
  • Author(s): Naito Y, Y abuta N, Sato J, Ohno S, Sakata M, Kasama T, Ikawa M, Nojima H
  • Journal Title: Cell Cycle Volume: 12 Issue: 11 Pages: 1773-1784
  • DOI: 10.4161/cc.24878
  • Peer Reviewed
• [Journal Article] Genetic analysis of genes causing hypertension and stroke in spontaneously hypertensive rats. (2013)
  • Author(s): Yamamoto H
  • Journal Title: International Journal of Molecular medicine Volume: 31 Issue: 5 Pages: 1057-1065
  • DOI: 10.3892/ijmm.2013.1304
  • Peer Reviewed
• [Journal Article] Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury. (2013)
  • Author(s): Del Re DP, Yang Y, Nakano N, Cho J, Zhai P, Yamamoto T, Zhang N, Yabuta N, Nojima H, Pan D, Sadoshima J
  • Journal Title: J Biol Chem Volume: 288 Issue: 6 Pages: 3977-88
  • DOI: 10.1074/jbc.m112.436311
  • Peer Reviewed
• [Journal Article] N-terminal truncation of Lats1 causes abnormal cell growth control and chromosomal instability. (2013)
  • Author(s): Yabuta N, Mukai S, Okamoto A, Okuzaki D, Suzuki H, Torigata K, Yoshida K, Okada N, Miura D, Ito A, Ikawa M, Okabe M, Nojima H.
  • Journal Title: Journal of Cell Science Volume: 126 Issue: 2 Pages: 508-520
  • DOI: 10.1242/jcs.113431
  • Peer Reviewed
• [Journal Article] Cancer susceptibility and embryonic lethality in Mobla/lb double-mutant mice. (2012)
  • Author(s): Nishio M.
  • Journal Title: J Clin Invest. Volume: 122 Issue: 12 Pages: 4505-4518
  • DOI: 10.1172/jci63735
  • Peer Reviewed
• [Journal Article] Ficolin 1 expression is elevated in the peripheral blood mononuclear cells of Takayasu's vasculitis patients (2012)
  • Author(s): Okuzaki D, Kobayashi S, Sakurai MA, T origata K, Okamoto A, Matsumoto T, Daida H, Ito A, Nojima H
  • Journal Title: J. Mol. Biomark Diagn Volume: 3 Pages: 125-125
  • Peer Reviewed
• [Journal Article] A simple and efficient method for the preparation of live leukocytes from peripheral blood using the LeukoCatch TM system. Adv . Biosci (2012)
  • Author(s): Okamoto A, T origata K, Sakurai MA, Okuzaki D, Fujii H, Ohmine T, Miura D, Kimura S, Yabuta N, Nojima H
  • Journal Title: Biotech Volume: 3 Pages: 630-642
  • Peer Reviewed
• [Journal Article] Cyclin G-associated kinase regulates protein phosphatase 2A by phosphorylation of its B'γ subunit (2012)
  • Author(s): Naito Y, Shimizu H, Kasama T, Sato J, Tabara H, Okamoto A, Yabuta N, Nojima H
  • Journal Title: Cell Cycle Volume: 11 Issue: 3 Pages: 604-16
  • DOI: 10.4161/cc.11.3.19114
  • Peer Reviewed
• [Journal Article] Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation. (2012)
  • Author(s): Zhang K, Rodriguez-Aznar E, Yabuta N,Owen RJ, Mingot JM, Nojima H, Nieto MA, Longmore GD
  • Journal Title: EMBO J Volume: 31 Issue: 1 Pages: 29-43
  • DOI: 10.1038/emboj.2011.357
  • Peer Reviewed
• [Journal Article] Ficolin 1 expression is elevated in the peripheral blood mononuclear cells of Takayasu's vasculitis patients. (2012)
  • Author(s): Okuzaki D, Kobayashi S, Sakurai MA, Torigata K, Okamoto A, Matsumoto T, Daida H, Ito A, Nojima H.
  • Journal Title: J Mol Biomark Diagn Volume: 3 Pages: 125-125
  • Peer Reviewed
• [Journal Article] A simple and efficient method for the preparation of live leukocytes from peripheral blood using the LeukoCatchTM system. (2012)
  • Author(s): Okamoto A, Torigata K, Sakurai MA, Okuzaki D, Fujii H, Ohmine T, Miura D, Kimura S, Yabuta N, Nojima H.
  • Journal Title: Adv Biosci Biotech Volume: 3 Pages: 630-642
  • Peer Reviewed
• [Journal Article] Cyclin G-associated kindse regulates protein phosphatase 2A by phosphorylation of its B' gamma subunit (2012)
  • Author(s): Naito Y, Shimizu H, Kasama T, Sato J, Tabara H, Okamoto A, Yabuta N, Nojima H
  • Journal Title: Cell Cycle Volume: VOL11 Pages: 604-616
  • Peer Reviewed
• [Journal Article] Neonatal lethality in knockout mice expressing the kinase-dead form of the gefitinib target GAK is caused by pulmonary dysfunction (2011)
  • Author(s): Tabara H, Naito Y, Ito A, Katsuma A, Sakurai MA, Ohno S, Shimizu H, Yabuta N, Nojima H
  • Journal Title: PLoS One Volume: 6 Issue: 10 Pages: e26034-e26034
  • DOI: 10.1371/journal.pone.0026034
  • Peer Reviewed
• [Journal Article] Microarray analysis of tonsils of IgA nephropathy patients. (2011)
  • Author(s): Iwatani H, Iio K, Nagasawa Y, Yamamoto R, Horii A, Okuzaki D, Inohara H, Nojima H, Imai E, Rakugi H, Isaka Y.
  • Journal Title: Adv Otorhinolaryngol. Volume: 72 Pages: 75-8
  • DOI: 10.1159/000324611
  • ISBN: 9783805597227, 9783805597234
  • Peer Reviewed
• [Journal Article] LeukoCatch, a quick and efficient tool for the preparation of leukocyte extracts from blood (2011)
  • Author(s): Okuzaki D, Kimura S, Yabuta N, Ohmine T, Nojima H.
  • Journal Title: BMC Clinical Pathology Volume: 11 Issue: 1 Pages: 9-9
  • DOI: 10.1186/1472-6890-11-9
  • Peer Reviewed
• [Journal Article] The tumor suppressor Lats2 is pivotal in Aurora A and Aurora B signaling during mitosis. (2011)
  • Author(s): Yabuta N, Mukai S, Okada N, Aylon Y, Nojima H
  • Journal Title: Cell Cycle Volume: 10 Issue: 16 Pages: 2724-36
  • DOI: 10.4161/cc.10.16.16873
  • Peer Reviewed
• [Journal Article] Microarray analysis of tonsils of IgA nephropathy patients (2011)
  • Author(s): Iwatani H, Iio K, Nagasawa Y, Yamamoto R, Horii A, Okuzaki D, Inohara H, Nojima H, Imai E, Rakugi H, Isaka Y
  • Journal Title: Adv Otorhinolaryngol Volume: VOL72 Pages: 75-78
  • Peer Reviewed
• [Journal Article] Leuko Catch, a quick and efficient tool for the preparation of leukocyrte extracts from blood (2011)
  • Author(s): Okuzaki D, Kimura S, Yabuta N, Ohmine T, Nojima H
  • Journal Title: BMC Clinical Pathology Volume: VOL11:9 Pages: 1-11
  • Peer Reviewed
• [Journal Article] Preparation of a high-quality cDNA library from a single-cell quantity of mRNA using chum-RNA (2011)
  • Author(s): Nojima H, Tougan T
  • Journal Title: Methods Mol Biol Volume: VOL729 Pages: 15-35
  • Peer Reviewed
• [Presentation] 癌抑制遺伝子 Lats1 は中心体の複製と細胞周期の進行に重要である (2013)
  • Author(s): 向井智美, 吉田佳織, 岡本歩, 清成寛, 藪田紀一, 野島博
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2013-12-05
• [Presentation] CyclinG-PP2A B'γ 複合体の結合阻害を標的としたペプチド抗癌医薬の開発 (2013)
  • Author(s): 大野将一, 内藤陽子, 藪田紀一, 野島博
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2013-12-04
• [Presentation] M 期進行における癌抑制キナーゼLats1/2 による新たな Aurora-B の活性制御機構 (2013)
  • Author(s): 吉田佳織, 藪田紀一, 向井智美, 野島博
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2013-12-04
• [Presentation] がん抑制因子 Lats1/2キナーゼはがん幹細胞のスフェア形成過程を制御する (2013)
  • Author(s): 福澤萌, 野崎正美, 向井智美, 岡本歩, 藪田紀一, 野島博
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2013-12-04
• [Presentation] LATS2 はエピゲノム調節機構を介して HOX cluster や DLK1 - MEG3 locusの発現を制御する (2013)
  • Author(s): 鳥形康輔, 奥崎大介, 藪田紀一, 野島博
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2013-12-04
• [Presentation] Withaferin A は癌細胞選択的にオートファジーと細胞死を誘導する (2013)
  • Author(s): 西川幸宏, 尾崎友紀, 篠倉悠久, 奥崎大介, 藪田紀一, 野島博
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2013-12-03
• [Presentation] Lats2 phosphorylates p21 and induces apoptosis in response to UV irradiation (2013)
  • Author(s): Hirokazu Suzuki, Norikazu Yabuta, Kosuke Torigata, Nobuhiro Okada, Yael Aylon, Mosh Oren and Hiroshi Nojima
  • Organizer: Molecular Life Sciences 2013
  • Place of Presentation: Frankfurt, Germany
  • Year and Date: 2013-10-04
• [Presentation] Lats2 phosphorylates p21 and induces apoptosis in response to UV irradiation (2013)
  • Author(s): Hirokazu Suzuki, Norikazu Yabuta, Kosuke Torigata, Nobuhiro Okada, Yael Aylon, Mosh Oren and Hiroshi Nojima
  • Organizer: The 5th EMBO meeting 2013
  • Place of Presentation: Amsterdam, Netherland
  • Year and Date: 2013-09-22
• [Presentation] Lats2 は p21 へのリン酸化を介してアポトーシスを誘導する (2013)
  • Author(s): 鈴木宏和,藪田紀一,鳥形浩輔,岡田宣宏, アイロン ヤエール, オーレン モッシュ,野島博
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2013-09-13
• [Presentation] LATS2 依存的な新規エピジェネティック制御機構の探索 (2013)
  • Author(s): 鳥形康輔, 向井智美,鈴木宏和,奥崎大介, 藪田紀一, 野島博
  • Organizer: 第7回日本エピジェネティクス研究会
  • Place of Presentation: 奈良
  • Year and Date: 2013-05-30
• [Presentation] CyclinG-PP2A B’γ複合体の結合阻害を標的としたペプチド抗癌医薬の開発 (2013)
  • Author(s): 大野 将一, 内藤 陽子, 藪田 紀一, 野島 博
  • Organizer: 第３６回日本分子生物学会年会
  • Place of Presentation: 神戸国際会議場
• [Presentation] 癌抑制遺伝子Lats1は中心体の複製と細胞周期の進行に重要である (2013)
  • Author(s): 向井 智美, 吉田 佳織, 岡本 歩, 清成 寛, 藪田 紀一, 野島 博
  • Organizer: 第３６回日本分子生物学会年会
  • Place of Presentation: 神戸国際会議場
• [Presentation] M期進行における癌抑制キナーゼLats1/2による新たなAurora-Bの活性制御機構 (2013)
  • Author(s): 吉田 佳織, 藪田 紀一, 向井 智美, 野島 博
  • Organizer: 第３６回日本分子生物学会年会
  • Place of Presentation: 神戸国際会議場
• [Presentation] Lats2はp21へのリン酸化を介してアポトーシスを誘導する (2013)
  • Author(s): 鈴木宏和、藪田紀一、鳥形浩輔、岡田宣宏、アイロン ヤエール、オーレン モッシュ、野島博
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] rChum, A Novel RNA Molecule to Aid PCR Amplification and Detection of Ultralow Amount of Nucleic Acids (2012)
  • Author(s): 鳥形康輔, 奥崎大介, 岡本歩, 野島博
  • Organizer: アジア太平洋血管炎・ANCA 国際会議 (AP-VAS2012)
  • Place of Presentation: 東京
  • Year and Date: 2012-03-29
• [Presentation] LeukoCatch, a novel tool for the preparation of leukocytes and their extracts from peripheral blood (2012)
  • Author(s): 岡本歩, 奥崎大介, 鳥形康輔, 野島博
  • Organizer: アジア太平洋血管炎・ANCA 国際会議 (AP-VAS2012)
  • Place of Presentation: 東京
  • Year and Date: 2012-03-29
• [Presentation] rChum, A Novel RNA Molecule to Aid PCR Amplification and Detection of Ultralow Amount of Nucleic Acids (2012)
  • Author(s): 鳥形康輔
  • Organizer: アジア太平洋血管炎・ANCA国際会議(AP-VAS2012)
  • Place of Presentation: 東京コンファレンスセンター品川(東京都)
  • Year and Date: 2012-03-29
• [Presentation] Leuko Catch, a novel tool for the preparation of leukocytes and their extracts from peripheral blood (2012)
  • Author(s): 岡本歩
  • Organizer: AP-VAS2012
  • Place of Presentation: 東京コンファレンスセンター・品川(東京都)
  • Year and Date: 2012-03-29
• [Presentation] Lats2 phosphorylates p21 and induces apoptosis in response to UV (2011)
  • Author(s): 鈴木宏和, 岡田宣宏, 藪田紀一, 野島博
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-16
• [Presentation] Lats2 phosphorylates p21 and induces apoptosis in response to UV (2011)
  • Author(s): 鈴木宏和
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-12-16
• [Presentation] Lats2, a Hippo pathway player , also regulates the DNA damage response (2011)
  • Author(s): 野島博
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-15
• [Presentation] Lats2, a Hippo pathway player, also regulates the DNA damage response (2011)
  • Author(s): 野島博
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-12-15
• [Presentation] Lats1 キナーゼの N 末端領域は染色体安定性,腫瘍抑制に必要である (2011)
  • Author(s): 向井智美, 藪田紀一, 岡本歩, 鈴木宏和, 岡田宣宏, 三浦大作, 奥崎大介, 野島博
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-22
• [Presentation] Lats1キナーゼのN末端領域は染色体安定性、腫瘍抑制に必要である (2011)
  • Author(s): 向井智美
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都国際会館(京都府)
  • Year and Date: 2011-09-22
• [Presentation] Lats1 and Lats2 kinases regulate chromosomal instability (2011)
  • Author(s): 藪田紀一, 向井智美, 鈴木宏和, 岡田宣宏, 三浦大作, 奥崎大介, 野島博
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-21
• [Presentation] Lats1 and Lats2 kinases regulate chromosomal instability (2011)
  • Author(s): 藪田紀一
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都国際会館(京都府)
  • Year and Date: 2011-09-21
• [Presentation] N 末端領域を欠損した Lats1 キナーゼは染色体不安定性と腫瘍形成を誘導する (2011)
  • Author(s): 向井智美, 藪田紀一, 岡本歩, 鈴木宏和, 岡田宣宏, 三浦大作, 奥崎大介, 野島博
  • Organizer: 第58回日本生化学会近畿支部例会
  • Place of Presentation: 大阪
  • Year and Date: 2011-05-21
• [Presentation] N末端領域を欠損したLats1キナーゼは染色体不安定性と腫瘍形成を誘導する (2011)
  • Author(s): 向井智美
  • Organizer: 第58回日本生化学会近畿支部例会
  • Place of Presentation: 関西医科大学(大阪府)
  • Year and Date: 2011-05-21
• [Book] DVD で見るバイオ実験(野島博 編) (2013)
  • Author(s): 野島博
  • Total Pages: 198
  • Publisher: 講談社
• [Book] 現代化学3月号「がん細胞のみを特異的に殺す生薬成分は有望か?」 (2013)
  • Author(s): 尾崎友紀, 野島博
  • Total Pages: 6
  • Publisher: 東京化学同人
• [Book] "Hippo in Cell Cycle and Mitosis"「 The Hippo Signaling Pathway and Cancer 」 (2013)
  • Author(s): Yabuta N, Nojima H
  • Publisher: Springer
• [Book] DVDで見るバイオ実験 （編 野島博） (2013)
  • Author(s): 野島 博
  • Total Pages: 198
  • Publisher: 講談社
• [Book] 現代化学 ３月号「がん細胞のみを特異的に殺す生薬成分は有望か？」 (2013)
  • Author(s): 尾崎友紀、野島 博
  • Total Pages: 6
  • Publisher: 東京化学同人
• [Book] The Hippo Signaling Pathway and Cancer (Eds. Moshe Oren, Yael Aylon), Chapter 10 “Hippo in Cell Cycle and Mitosis” (2013)
  • Author(s): Yabuta N, Nojima H
  • Total Pages: 23
  • Publisher: Springer
• [Book] 「DNA 損傷シグナリング」シグナル伝達キーワード事典 (2012)
  • Author(s): 藪田紀一, 野島博
  • Publisher: 羊土社
• [Book] シグナル伝達キーワード事典 （編 山本雅・仙波憲太郎・山梨裕司）、「DNA損傷シグナリング」の項 (2012)
  • Author(s): 藪田紀一、野島博
  • Total Pages: 3
  • Publisher: 羊土社
• [Book] 「細胞増殖・細胞死制御と Hippo pathway : Lats キナーゼを中心に」細胞工学 (2011)
  • Author(s): 藪田紀一, 野島博
  • Publisher: 秀潤社
• [Book] 細胞工学30巻9号特集「Hippo Pathway-癌・細胞死・再生の新たな鍵を握る器官サイズ制御シグナル」「細胞増殖・細胞死制御とHippo pathway : Latsキナーゼを中心に」の項 (2011)
  • Author(s): 藪田紀一、野島博
  • Total Pages: 7
  • Publisher: 秀潤社
• [Remarks]
  • URL: http://molgenet.biken.osaka-u.ac.jp/index.html
• [Remarks] 大阪大学微生物病研究所分子遺伝研究分野ホームページ
  • URL: http://molgenet.biken.osaka-u.ac.jp/index.html
• [Remarks]
  • URL: http://www.biken.osaka-u.ac.jp/lab/molgenet/index.html
• [Patent(Industrial Property Rights)] 細胞死促進剤 (2014)
  • Inventor(s): 野島博
  • Industrial Property Rights Holder: 大阪大学知的財産本部
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-052612
  • Filing Date: 2014-03-14