Preventive effects of marine carotenoids on chronic inflammation-related diseases through regulation of cell and tissue communication
| Project/Area Number |
23380120
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fisheries chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
HOSOKAWA Masashi 北海道大学, 大学院水産科学研究院, 准教授 (10241374)
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| Co-Investigator(Kenkyū-buntansha) |
YASUI Yumiko 酪農学園大学, 獣医学部, 准教授 (90434472)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | フコキサンチン / アスタキサンチン / 慢性炎症 / 肥満 / 脂肪組織 / 潰瘍性大腸炎 / ケモカイン / 組織・細胞間相互作用 / 海洋性カロテノイド / 肥満予防 / 潰瘍性大腸炎予防 / サイトカイン / 組織・細胞間相互作用制御 / 抗メタボリックシンドローム予防作用 / 潰瘍性大腸炎予防効果 / カロテノイド / 抗肥満作用 / ペクテノロン / 抗癌作用 |
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| Research Abstract |
Fucoxanthin (Fx) suppressed chronic inflammation in white adipose tissue by the inhibition of macrophage and T cell infiltration. Further, Fx down-regulated mRNA expression of chemokines and adipokines, which recruit immune cells and induce insulin resistance. In diabetic/obese mice fed Fx, GLUT4 activation was observed in skeletal muscle through the improvement of hyperglycemia. On the other hand, Fx and astaxanthin (Asx) extracted from H. pluvialis prevent DSS-induced colitis and colon carcinogenesis in mice. In colon of the mice fed Asx, mRNA expression levels of inflammatory cytokines tended to decrease compared to control mice. In addition, Asx down-regulated mRNA expression of inflammatory cytokines in macrophage-like cells and colon cells stimulated by the culture medium of activated macrophages. These results suggest that marine carotenoids prevent chronic inflammation and its-related diseases by the regulation of cell and tissue communication via chemokines and cytokines.
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Report
(4 results)
Research Products
(71 results)
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[Journal Article] Regulation of polyunsaturated fatty acid biosynthesis by seaweed fucoxanthin and its metabolite in cultured hepatocytes.2014
Author(s)
Aki, T., Yamamoto, M., Takahashi, T., Tomita, K., Toyoura, Ri., Iwashita, K., Kawamoto, S., Hosokawa, M., Miyashita, K., Ono, K.
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Journal Title
Lipids
Volume: 49
Issue: 2
Pages: 133-141
DOI
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Peer Reviewed
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[Journal Article] Early-stage formation of an epigenetic field defect in a mouse colitis model, and non-essential roles of T- and B-cells in DNA methylation induction.2012
Author(s)
Katsurano M, Niwa T, Yasui Y, Shigematsu Y, Yamashita S, Takeshima H, Lee MS, Kim YJ, Tanaka T, Ushijima T.
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Journal Title
Oncogene
Volume: 32
Issue: 3
Pages: 342-351
DOI
Related Report
Peer Reviewed
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[Book] “Substrate and droplet size: important factors for understanding aqueous lipid oxidation” In: Lipid Oxidation: Challenges in Food Systems (Logan, A., Nienaber, U., Pan, X. eds)2013
Author(s)
K. Miyashita, M., Hosokawa.
Total Pages
22
Publisher
AOCS Press, Urbana, IL, pp. 155-176 (2013).
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