| Project/Area Number |
23390026
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SHISHIDO Kozo 徳島大学, ヘルスバイオサイエンス研究部, 非常勤講師 (20006349)
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| Co-Investigator(Kenkyū-buntansha) |
OTAKA Akira 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (20201973)
ITOH Kohji 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (00184656)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIGENAGA Akira 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (10423394)
TSUJI Daisuke 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (00423400)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
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| Keywords | 天然物 / 不斉合成 / 創薬 / 標的タンパク / ケミカルバイオロジー / ベイト分子 / プルダウン法 / プロテオミクス / 標的タンパク質 / アポトーシス / 細胞接着 / プルダウンアッセイ / アスパーギライド / 細胞毒性 / ビオチン / 光親和性標識 / クリックケミストリー / 標的タンパク同定 |
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| Research Abstract |
Novel and highly efficient methodology for the synthesis of marine-derived natural products aspergillides A, B and C with antitumor activity was developed. It can also be applied to the synthesis of a wide variety of related compounds and we were able to have a unique compounds library, from which a new molecule with higher biological activity than the natural products was obtained. In addition, a lariat molecule that enables enrichment and selective labeling of target proteins of the bioactive compounds for efficient identification of the target proteins was successfully invented.
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