Adjuvant effect of chemicals on contact hypersensitivity through transient receptor potential channels
| Project/Area Number |
23390031
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
IMAI Yasuyuki 静岡県立大学, 薬学部, 教授 (80160034)
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| Co-Investigator(Kenkyū-buntansha) |
KUROHANE Kohta 静岡県立大学, 薬学部, 助教 (90333525)
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| Co-Investigator(Renkei-kenkyūsha) |
WATANABE Tatsuo 静岡県立大学, 食品栄養科学部, 教授 (10210915)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Keywords | フタル酸エステル / 接触性皮膚炎 / TRPチャネル / 知覚神経 / 代替可塑剤 / アジュバント / アレルギー・ぜんそく / 衛生 / 免疫学 / 薬学 / 神経科学 |
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| Research Abstract |
Adjuvant mechanisms of chemicals in allergy are largely unknown. We demonstrated that TRPA1 channels are involved in the adjuvant activity of phthalate esters using a contact hypersensitivity mouse model. This conclusion was supported by the presence of adjuvant activity in TRPA1 agonistic natural products as well as by experiments using a TRPA1 antagonist. TRPA1 activation was found to be useful for the prediction of adjuvant effect using alternative plasticizers that are widely used for cosmetics and drug formulation.
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Report
(4 results)
Research Products
(18 results)
