Proteomic and metabolomic analysis on chemo-sensitivity and resistance of cancer towards personalized medicine
| Project/Area Number |
23390037
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHI Koji 慶應義塾大学, 医学部, 特任講師 (00398249)
NISHIMUTA Akito 慶應義塾大学, 医学部, 特任助教 (00424135)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2011: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 抗がん剤 / 薬剤反応性 / プロテオーム / メタボローム / オーダーメイド医療 / がん治療 / オキサリプラチン / ゲムシタビン |
|---|
| Research Abstract |
Inter-patient variability in the efficacy of cancer pharmacotherapy is one of the most difficult obstacles to improve cancer therapy. The present research investigated cellular mechanisms of pharmacological action of chemotherapeutic agents and resistant mechanisms of cancer against the drug action. The methods we used were the latest proteomic and metabolomic analyses which measured intracellular expression of abundant proteins and metabolites. Based on comprehensive metabolomic fingerprints and protein expression analysis, we have discovered several new proteins and metabolites that are related to the chemo-sensitivity or drug resistance of cancer. These findings are expected to lead to develop a new personalized cancer pharmacotherapy.
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Report
(4 results)
Research Products
(73 results)
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[Journal Article] Clinical practice guidelines for therapeutic drug monitoring of arbekacin: a consensus review of the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring2014
Author(s)
Okada K, Kimura T, Mikamo H, Kasahara K, Seki M, Takakura S, Tokimatsu I, Ohmagari N, Takahashi Y, Matsumoto K, Igarashi M, Kobayashi M, Hamada Y, Mochizuki T, Kimura M, Nishi Y, Tanigawara Y, Takesue Y
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Journal Title
J Infect Chemother
Volume: 20(1)
Pages: 1-5
DOI
Related Report
Peer Reviewed
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[Journal Article] Polymorphisms of UGT1A1 gene predict adverse effects of irinotecan treatment for gynecologic cancer in Japanese.2013
Author(s)
Hirasawa A, Zama T, Akahane T, Nomura H, Kataoka F, Saito K, Okubo K, Tominaga E, Makita K, Susumu N, Kosaki K, Tanigawara Y, Aoki D
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Journal Title
J Hum Genet
Volume: 58(12)
Pages: 794-798
DOI
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Peer Reviewed
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[Journal Article] Clinical and bacteriological efficacies of sitafloxacin against community-acquired pneumonia caused by Streptococcus pneumoniae: nested cohort within a multicenter clinical trial2013
Author(s)
Fujita J, Niki Y, Kadota J, Yanagihara K, Kaku M, Watanabe A, Aoki N, Hori S, Tanigawara Y, Cash HL, Kohno S
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Journal Title
J Infect Chemother
Volume: 19(3)
Pages: 472-479
DOI
Related Report
Peer Reviewed
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[Journal Article] Practice guidelines for therapeutic drug monitoring of voriconazole: a consensus review of the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring2013
Author(s)
Hamada Y, Tokimatsu I, Mikamo H, Kimura M, Seki M, Takakura S, Ohmagari N, Takahashi Y, Kasahara K, Matsumoto K, Okada K, Igarashi M, Kobayashi M, Mochizuki T, Nishi Y, Tanigawara Y, Kimura T, Takesue Y
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Journal Title
J Infect Chemother
Volume: 19(3)
Pages: 381-392
DOI
Related Report
Peer Reviewed
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[Journal Article] Practice guidelines for therapeutic drug monitoring of vancomycin : a consensus review of the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring2013
Author(s)
Matsumoto K, Takesue Y, Ohmagari N, Mochizuki T, Mikamo H, Seki M, Takakura S, Tokimatsu I, Takahashi Y, Kasahara K, Okada K, Igarashi M, Kobayashi M, Hamada Y, Kimura M, Nishi Y, Tanigawara Y, Kimura T
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Journal Title
J Infect Chemother
Volume: 19(3)
Pages: 365-380
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] A genome-wide association study identifies locus at 10q22 associated with clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients in Japanese.2012
Author(s)
K.Kiyotani, T.Mushiroda, T.Tsunoda, T.Morizono, N.Hosono, M.Kubo, Y.Tanigawara, CK.Imamura, DA.Flockhart, F.Aki, K.Hirata, Y.Takatsuka, M.Okazaki, S.Ohsumi, T.Yamakawa, M.Sasa, Y.Nakamura, H.Zembutsu
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Journal Title
Hum Mol Genet.
Volume: (オンライン出版済)
Pages: 1665-1672
DOI
Related Report
Peer Reviewed
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[Journal Article] Expression changes in arrestin β 1 and genetic variation in catechol-O-methyltransferase are bioraarkers for the response to morphine treatment in cancer patients.2012
Author(s)
H.Matsuoka, T.Arao, C.Makimura, M.Takeda, H.Kiyota, J.Tsurutani, Y.Fujita, K.Matsumoto, H.Kimura, M.Otsuka, A.Koyama, CK.Imamura, Y.Tanigawara, T.Yamanaka, K.Tanaka, K.Nishio, K.Nakagawa
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Journal Title
Oncol Rep.
Volume: 27(5)
Pages: 1393-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Pharmacokinetics of eldecalcitol in primary osteoporosis patients-Randomaized, double-blind, multicentre, long-term phase III clinical Study2011
Author(s)
K.Miyata, M.Abe, K.Terao, T.Kawanishi, N.Tsuji, M.Shiraki, T.Nakamura, T.Matsumoto, Y.Tanigawara
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Journal Title
Jpn.Pharmacol.Ther.
Volume: 39
Pages: 299-307
Related Report
Peer Reviewed
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[Journal Article] A genome-wide association study identifies locus at 10q22 associated with clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients in Japanese2011
Author(s)
K.Kiyotani, T.Mushiroda, T.Tsunoda, T Morizono, N Hosono, M.Kubo, Y.Tanigawara, CK.Imamura, DA Flockhart, F.Aki, K.Hirata, Y.Takatsuka, M.Okazaki, S.Ohsumi, T.Yamakawa, M.Sasa, Y.Nakamura, H.Zembutsu
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Related Report
Peer Reviewed
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