Influence of various types of receptor tyrosine kinase gene mutations in pathogenesis of GISTs
| Project/Area Number |
23390094
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUKAMOTO Yoshitane 兵庫医科大学, 医学部, 准教授 (70461085)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2011: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | c-kit遺伝子 / キナーゼドメインII / 遺伝子改変マウス / シグナル系 / imatinib / nilotinib / GIST多発家系 / 細胞外領域 / GIST / 家族性GIST / ノックインマウス / シグナル伝達物質 / 消化管間質腫瘍 / チロシンキナーゼ / 遺伝子変異 / 培養細胞 / 機能獲得性突然変異 / 傍細胞膜領域 / シグナル伝達 |
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| Research Abstract |
Signal transduction system activated in immortalized mast cell line which is derived from cultured mast cells of knock-in mice with germline homozygous mutation at kinase domain II was different from that in cultured mast cells of knock-in mice with germline homozygous mutation. The immortalized mast cell line had an additional mutation in the c-kit gene.
Activation of newly found juxtamembrane domain germline c-kit gene gain-of-function mutation in familial GISTs was effectively inhibited by imatinib and nilotinib. We also found that activation of newly found extracellular domain c-kit gene mutation in sporadic GISTs is effectively inhibited by imatinib and nilotinib, compared to that of conventional extracellular domain c-kit gene mutation.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Adjuvant therapy with imatinib mesylate after resection of primary high-risk gastrointestinal stromal tumors in Japanese patients2013
Author(s)
Kanda T, Nishida T, Wada N, Kobayashi O, Yamamoto M, Sawaki A, Boku N, Koseki M, Doi T, Toh Y, Kakeji Y, Sugiyama T, Komatsu Y, Kikuchi S, Ogoshi K, Katai H, Miyachi K, Hirota S, Ohtsu A
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Journal Title
Int J Clin Oncol
Volume: 18
Issue: 1
Pages: 38-45
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Clinical significance of surgery for gastric submucosal tumors with size enlargement during watchful waiting period2013
Author(s)
Miyazaki Y, Nakajima K, Kurokawa Y, Takahashi T, Takiguchi S, Miyata H, Yamasaki M, Hirota S, Nishida T, Mori M, Doki Y
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Journal Title
Eur J Cancer
Volume: 49
Issue: 12
Pages: 2681-2688
DOI
Related Report
Peer Reviewed
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[Journal Article] Characterization of novel germline c-kit gene mutation, KIT-Tyr553Cys, observed in a family with multiple gastrointestinal stromal tumors2012
Author(s)
Nakai M, Hashikura Y, Ohkouchi M, Yamamura M, Akiyama T, Shiba K, Kajimoto N, Tsukamoto Y, Hao H, Isozaki K, Hirai T, Hirota S
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Journal Title
Lab Invest
Volume: 92
Issue: 3
Pages: 451-457
DOI
Related Report
Peer Reviewed
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