| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2011: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Research Abstract |
In this study, we tried to reveal the molecular and cellular mechanisms of activation of anti-tumor immunity by CD169-positive macrophages located in lymph node sinus. We generated CD169-Cre-YFP mice, in which CD169-positive macrophages were specifically labeled with YFP, and examined the character of these cells using the mice. We also identified CD169 macrophages-producing molecules that may be able to activate anti-tumor immunity. We established an experimental model to induce cell death of tumor cells in tumor-bearing mice, found the drastic changes in tumor-associated macrophages after tumor cell death. We also reveal the roles of CD169 macrophages in the immune regulation in non-immune tissues.
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