Response and specific function of IFN-lambda3 against infectious diseases
| Project/Area Number |
23390117
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
MIZOAKMI Masashi 独立行政法人国立国際医療研究センター, その他部局等, その他 (40166038)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIYAMA Masaya 国立国際医療研究センター, 肝炎・免疫研究センター, 上級研究員 (20612427)
MURATA Kazumoto 国立国際医療研究センター, 肝炎・免疫研究センター, 室長 (40345971)
SUZUKI Yoshiyuki 名古屋市立大学, 大学院・システム自然科学研究科, 教授 (70353430)
伊藤 清顕 国立国際医療研究センター, 肝炎・免疫研究センター, 室長 (50551420)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | インターフェロンラムダ / 転写 / シグナル伝達 / 進化 / 受容体 |
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| Research Abstract |
We have newly developed a detection assay for IFN-lambda3 protein, being encoded by IL28B gene that predict the efficacy of pegylated interferon and ribavirin (Peg-IFN/RBV) therapy for chronic hepatitis C patients. Using this assay, we demonstrated that IFN-lambda3 levels in the supernatant of peripheral mononuclear cells stimulated with toll-like receptor 7 agonist or serum levels of IFN-lambda3 more favorably predict the efficay of Peg-IFN/RBV treatment rather than genetic variation of IL28B. We also demonstrated that human BDCA3+dendritic cells recognize hepatitis C virus and produce IFN-lambda3 through toll-like receptor 3 pathway.
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Report
(4 results)
Research Products
(98 results)
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[Journal Article] Ex vivo induction of IFN-λ3 by a TLR7 agonist determines response to Peg-IFN/ ribavirin therapy in chronic hepatitis C patients2014
Author(s)
Murata K, Sugiyama M, Kimura T, Yoshio S, Kanto T, Kirikae I, Saito H, Aoki Y, Hiramine S, Matsui T, Ito K, Korenaga M, Imamura M, Masaki N, Mizokami M
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Journal Title
J Gastroenterol
Volume: 49(1)
Issue: 1
Pages: 126-37
DOI
Related Report
Peer Reviewed
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[Journal Article] IL28B polymorphisms and clinical implications for hepatitis C virus infection in Uzbekistan2014
Author(s)
Khudayberganova D, Sugiyama M, Masaki N, Nishida N, Mukaide M, Sekler D, Latipov R, Nataliya K, Dildora S, Sharapov S, Usmanova G, Raxmanov M, Musabaev E, Mizokami M
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Journal Title
PLoS One
Volume: 24;9
Issue: 3
Pages: e93011-e93011
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Risk factors for long-term persistence of serum hepatitis B surface antigen following acute hepatitis B virus infection in Japanese adults2014
Author(s)
Ito K, Yotsuyanagi H, Yatsuhashi H, Karino Y, Takikawa Y, Saito T, Arase Y, Imazeki F, Kurosaki M, Umemura T, Ichida T, Toyoda H, Yoneda M, Mita E, Yamamoto K, Michitaka K, Maeshiro T, Tanuma J, Tanaka Y, Sugiyama M, Murata K, Masaki N, Mizokami M; Japanese AHB Study Group
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Journal Title
Hepatology
Volume: 59
Issue: 1
Pages: 89-97
DOI
Related Report
Peer Reviewed
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[Journal Article] Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP)2014
Author(s)
Watashi K, Sluder A, Daito T, Matsunaga S, Ryo A, Nagamori S, Iwamoto M, Nakajima S, Tsukuda S, Borroto-Esoda K, Sugiyama M, Tanaka Y, Kanai Y, Kusuhara H, Mizokami M, Wakita T
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Journal Title
Hepatology
Volume: 59
Issue: 5
Pages: 1726-1737
DOI
Related Report
Peer Reviewed
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[Journal Article] New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia.2014
Author(s)
Nishida N, Sawai H, Kashiwase K, Minami M, Sugiyama M, Seto WK, Yuen MF, Posuwan N, Poovorawan Y, Ahn SH, Han KH, Matsuura K, Tanaka Y, Kurosaki M, Asahina Y, Izumi N, Kang JK, （省略）, Tokunaga K, and Mizokami M
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Journal Title
PLoS One
Volume: 9
Issue: 2
Pages: e86449-e86449
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Human blood dendritic cell antigen 3 (BDCA3)(+) dendritic cells are a potent producer of interferon-λ in response to hepatitis C virus2013
Author(s)
Yoshio S, Kanto T, Kuroda S, Matsubara T, Higashitani K, Kakita N, Ishida H, Hiramatsu N, Nagano H, Sugiyama M, Murata K, Fukuhara T, Matsuura Y, Hayashi N, Mizokami M, Takehara T
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Journal Title
Hepatology
Volume: 57
Issue: 5
Pages: 1705-15
DOI
Related Report
Peer Reviewed
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[Journal Article] Targeted induction of interferon-λ in humanized chimeric mouse liver abrogates hepatotropic virus infection2013
Author(s)
Nakagawa S, Hirata Y, Kameyama T, Tokunaga Y, Nishito Y, Hirabayashi K, Yano J, Ochiya T, Tateno C, Tanaka Y, Mizokami M, Tsukiyama-Kohara K, Inoue K, Yoshiba M, Takaoka A, Kohara M
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Journal Title
PLoS One
Volume: 8
Issue: 3
Pages: e59611-e59611
DOI
Related Report
Peer Reviewed
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[Journal Article] LecT-Hepa, a glyco-marker derived from multiple lectins, as a predictor of liver fibrosis in chronic hepatitis C patients2012
Author(s)
Ito K, Kuno A, Ikehara Y, Sugiyama M, Saito H, Aoki Y, Matsui T, Imamura M, Korenaga M, Murata K, Masaki N, Tanaka Y, Hige S, Izumi N, Kurosaki M, Nishiguchi S, Sakamoto M, Kage M, Narimatsu H, Mizokami M
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Journal Title
Hepatology
Volume: 56
Issue: 4
Pages: 1448-56
DOI
Related Report
Peer Reviewed
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[Journal Article] Factors responsible for the discrepancy between IL28B polymorphism prediction and the viral response to peginterferon plus ribavirin therapy in Japanese chronic hepatitis C patients2012
Author(s)
Saito H, Ito K, Sugiyama M, Matsui T, Aoki Y, Imamura M, Murata K, Masaki N, Nomura H, Adachi H, Hige S, Enomoto N, Sakamoto N, Kurosaki M, Mizokami M, Watanabe S
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Journal Title
Hepatol Res
Volume: 42(10)
Issue: 10
Pages: 958-65
DOI
Related Report
Peer Reviewed
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[Journal Article] Hepatitis C virus kinetics by administration of pegylated interferon-lin human and chimeric mice carrying human hepatocytes with variants of the IL28B gene2012
Author(s)
Watanabe T, Sugauchi F, Tanaka Y, Matsuura K, Yatsuhashi H, Murakami S, Iijima S, Iio E, Sugiyama M, Shimada T, Kakuni M, Kohara M, Mizokami M
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Journal Title
Gut
Volume: Nov 7
Issue: 9
Pages: 1340-6
DOI
Related Report
Peer Reviewed
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[Journal Article] The rs8099917 polymorphism, when determined by a suitable genotyping method, is a better predictor for response to pegylated alpha interferon/ribavirin therapy in Japanese patients than other single nucleotide polymorphisms associated with interleukin-28B2011
Author(s)
Ito K, Higami K, Masaki N, Sugiyama M, Mukaide M, Saito H, Aoki Y, Sato Y, Imamura M, Murata K, Nomura H, Hige S, Adachi H, Hino K, Yatsuhashi H, Orito E, Kani S, Tanaka Y, Mizokami M
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Journal Title
J Clin Microbiol
Volume: 49
Issue: 5
Pages: 1853-60
DOI
Related Report
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[Journal Article] Easy-to-use phylogenetic analysis system for hepatitis B virus infection2011
Author(s)
Sugiyama M, Inui A, Shin-IT, Komatsu H, Mukaide M, Masaki N, Murata K, Ito K, Nakanishi M, Fujisawa T, Mizokami M
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Journal Title
Hepatol Res
Volume: 41(10)
Issue: 10
Pages: 936-945
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] Pre-treatment levels of serum IFN-3 more accurately predict sustained virological response by pegylated interferon/ribavirin therapy than IL28B genotyping in chronic hepatitis C patients2013
Author(s)
Aoki Y, Murata K,, Sugiyama M, Kimura T, Takeda T, Yoshio S, Yamagiwa Y, Korenaga M, Imamura M, Kanto T, Masaki N, Mizokami M
Organizer
The 64th annual meeting of the American association for the study of liver diseases
Place of Presentation
Washington DC
Related Report
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[Presentation] Polymorphisms consisting of (TA)n dinucleotide repeat near IL28B gene could improve the predictive value for HCV spontaneous clearance with IL28B SNPs2013
Author(s)
Sugiyama M, Hiramine S, Furusho N, Ido A, Tsubouchi H, Watanabe H, Ueno Y, Korenaga M, Murata K,, Masaki N, Mizokami M
Organizer
The 64th annual meeting of the American association for the study of liver diseases
Place of Presentation
Washington DC
Related Report
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[Presentation] Significant roles of IFN-3 with reciprocal levels in serum and ex vivo stimulated PBMC in chronic hepatitis C2013
Author(s)
Aoki Y, Murata K,, Sugiyama M, Kimura T, Takeda T, Yoshio S, Nishida N, Yamagiwa Y, Korenaga M, Imamura M, Kanto T, Masaki N, Jong-Hon Kang, Mizokami M
Organizer
The 64th annual meeting of the American association for the study of liver diseases
Place of Presentation
Washington DC
Related Report
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[Presentation] Number of peripheral BDCA4+dendritic cells determines the response to pegylated interferon/ribavirin therapy in chronic hepatitis C patients2013
Author(s)
Murata K, Sugiyama M, Kimura T, Takeda T, Yoshio S, Aoki Y, Nishida N, Yamagiwa Y, Korenaga M, Imamura M, Kanto T, Masaki N, Mizokami M
Organizer
The 64th annual meeting of the American association for the study of liver diseases
Place of Presentation
Washington DC
Related Report
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[Presentation] Human BDCA3+DC contribute to the induction of intrahepatic ISGs as a potent IFN- producer in HCV infection2013
Author(s)
Yoshio S, Kanto T, Matsubara T, Sugiyama M, Murata K,, Fukuhara T, Matsuura Y, Mizokami M, Hayashi N, Takehara T
Organizer
The 64th annual meeting of the American association for the study of liver diseases
Place of Presentation
Washington DC
Related Report
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[Presentation] Different Amount of IFN-λ3 Determines the Outcome of Peg-IFN/RBV Therapy in HCV Patients.2012
Author(s)
Murata K, Sugiyama M, Kimura T, Yoshio S, Kanto T, Kirikae I, Aoki Y, Hiramine S, Matsui T, Korenaga M, Imamura M, Masaki N, Mizokami M.
Organizer
The 10th JSH Single Topic Conference
Place of Presentation
Tokyo
Related Report
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[Presentation] C型慢性肝炎における臨床背景の違いと治療法選択の現状と展開IP-10値を含めたPEG-IFN/RBV療法における治療予測因子の検討.2012
Author(s)
松浦健太郎, 田中靖人, 飯尾悦子, 日下部篤宣, 新海登, 宮木知克, 野尻俊輔, 渡邊綱正, 藤原圭, 折戸悦朗, 城卓志, 溝上雅史.
Organizer
第48回日本肝臓学会総会
Place of Presentation
金沢
Related Report
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