The NO conjugated-albumin nanoparticles for the application to multidisciplinary cancer treatment
| Project/Area Number |
23390142
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIMA Yu 熊本大学, 薬学部, 助教 (00457590)
WATANABE Hiroshi 熊本大学, 薬学部, 准教授 (70398220)
OTAGIRI Masaki 崇城大学, 薬学部, 教授 (80120145)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Keywords | DDS / アルブミン / 一酸化窒素 / 癌治療 |
|---|
| Research Abstract |
The enhanced permeability and retention (EPR) effect is a unique phenomenon of solid tumors related to their anatomical and pathophysiological differences from normal tissues, served as a basis for development of macromolecular anticancer therapy. Although many factors that affect vascular permeability in tumors have been identified, some parts of tumors do not exhibit the EPR effect and show less accumulation of macromolecules than other parts. We previously developed S-nitrosated HSA-Dimer (SNO-HSA-Dimer) as an enhancer of the EPR effect by applying nitric oxide (NO)-releasing agents in tumors selectively. In this study, we performed the effect of SNO-HSA-Dimer on the anti-tumor effect of two macromolecular anti-tumor drugs in C26 tumor-bearing mice. Intriguingly, SNO-HSA-Dimer inhibited the side effects of Doxil; through augmenting the EPR effect.
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Report
(4 results)
Research Products
(61 results)
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[Journal Article] Tuning of Poly-S-Nitrosated Human Serum Albumin as Superior Antitumor Nanomedicine2014
Author(s)
Ishima Y, Fang J, Kragh-Hansen U, Yin H, Liao L, Katayama N, Watanabe H, Kai T, Suenaga A, Maeda H, Otagiri M, Maruyama T
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Journal Title
J Pharm Sci
Volume: 103
Issue: 7
Pages: 2184-2188
DOI
Related Report
Peer Reviewed
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[Journal Article] Albumin fusion renders thioredoxin an effective anti-oxidative and anti-inflammatory agent for preventing cisplatin-induced nephrotoxicity.2014
Author(s)
Kodama A, Watanabe H, Tanaka R, Kondo M, Chuang VT, Wu Q, Endo M, Ishima Y, Fukagawa M, Otagiri M, Maruyama T.
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Journal Title
Biochim Biophys Acta.
Volume: 1840
Issue: 3
Pages: 1152-1162
DOI
Related Report
Peer Reviewed
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[Journal Article] p-Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress byactivation of NADPH oxidase.2013
Author(s)
Hiroshi Watanabe^*, Yohei Miyamoto^*,Daisuke Honda, Hisae Tariaka, Qiong Wu,Masayuki Endo, Tsuyoshi Noguchi, DaisukeKadowaki, Yu Ishima, Shunsuke Kotani,Makoto Nakajima, Keiichiro Kataoka,Shokei Kim-Mitsuyama, Motoko Tanaka,Masafumi Fukagawa, Masaki Otagiri, ToruMaruyama. (^*:Hiroshi Watanabe and YoheiMiyamoto contributed equally to this work.)
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Journal Title
Kidney International
Volume: (印刷中)
Issue: 4
Pages: 582-592
DOI
Related Report
Peer Reviewed
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[Journal Article] S-nitrosylated a-l-acid glycoprotein kills drug-resistant bacteria and aids survival in sepsis2013
Author(s)
Watanabe K, Ishima Y, Akaike T, Sawa T, Kuroda T, Ogawa W, Watanabe H, Suenaga A, Kai T, Otagiri M, and Maruyama T.
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Journal Title
FASEB J
Volume: 27
Issue: 1
Pages: 391-398
DOI
Related Report
Peer Reviewed
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[Journal Article] S-Guanylation of human serum albumin is a unique posttranslational modification and results in a novel class of antibacterial agents2012
Author(s)
Ishima Y, Hoshino H, Shinagawa T, Watanabe K, Akaike T, Sawa T, Kragh-Hansen U, Kai T, Watanabe H, Maruyama T, and Otagiri M
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Journal Title
J. Pharm. Sci
Volume: 101
Issue: 9
Pages: 3222-3229
DOI
Related Report
Peer Reviewed
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