Senescence-inducing stress modulates glycolysis and the Warburg effect
Project/Area Number |
23390186
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General internal medicine (including Psychosomatic medicine)
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Research Institution | Kyoto University |
Principal Investigator |
KONDOH Hiroshi 京都大学, 医学(系)研究科(研究院), 助教 (80402890)
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Co-Investigator(Kenkyū-buntansha) |
YOKODE Masayuki 京都大学, 医学研究科, 教授 (20252447)
|
Co-Investigator(Renkei-kenkyūsha) |
OKAMOTO Koji 国立がん研究センター研究所, 室長 (80342913)
SOGA Tomoyoshi 慶応大学, 環境情報学部, 教授 (60338217)
TAKAORI Akifumi 京都大学, 医学研究科, 教授 (20324626)
TANAKA Tomoaki 千葉大学, 医学部, 講師 (50447299)
|
Project Period (FY) |
2011-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2011: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
|
Keywords | 老化 / 老年医学 / 解糖系代謝 / 癌化 / ストレス老化 / 発癌 |
Research Abstract |
Our main concern is the senescence-bypassing effect of PGAM, glycolytic enzyme. We reported that PGAM is ubiquitinated by oncogene Mdm2 under senescence-inducing stress(Mikawa et al JCB 2014). We also identified HNF-1 as transcriptional regulator for glycolysis in ovarian cancer(Okamoto et al, Molecu Carci 2013). We reported PGAM impairs mitochondrial respiration in vivo(Okuda et al, PLOSONE 2013). We also found that PGAM is acetyalted in cancer cells. And We finally generated PGAM-TG mice. We also reported transforming ability of MEFs from PGAM-TG (Mikawa et al JCB 2014). Thus we disclosed unknown aspect of the Warburg effect through molecular investigation of PGAM.
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Report
(4 results)
Research Products
(60 results)
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[Journal Article] Senescence-inducing stress promotes proteolysis of glycolytic enzyme phosphoglycerate mutase via ubiquitin ligase Mdm22014
Author(s)
T Mikawa, T Maruyama, K Okamoto, H Nakagama, ME LLeonart, T Tsusaka, K Hori, I Murakami, T Izumi, A T-Kondo, M Yokode, G Peters, D Beach, & H Kondoh
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Journal Title
Journal of Cell Biology
Volume: 204(5)
Pages: 729-45
DOI
Related Report
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[Journal Article] Senescence-inducing stress promotes proteolysis of glycolytic enzyme phosphoglycerate mutase via ubiquitin ligase Mdm2.2014
Author(s)
T Mikawa, T Maruyama, K Okamoto, H Nakagama, ME LLeonart, T Tsusaka, K Hori, I Murakami, T Izumi , A Takaori-Kondo, M Yokode, G Peters, D Beach, and H Kondoh.
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Journal Title
Journal of Cell Biology
Volume: 204
Pages: 729-745
DOI
Related Report
Peer Reviewed
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[Journal Article] Hepatocyte nuclear factor-1β promotes glucose uptake and glycolytic activity in ovarian clear carcinoma2013
Author(s)
T Okamoto, M Mandai, N Matsumura, K Yamaguchi, H Kondoh, Y Amano, T Baba, J Hamanishi, K Abiko, K Kosaka, S K, Murphy, S Mori, I Konishi
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Journal Title
DOI
Related Report
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[Journal Article] Persistent overexpression of phosphoglycerate mutase, a glycolytic enzyme, modifies energy metabolism and reduces stress resistance of heart in mice2013
Author(s)
Okuda J, Niizuma S, Shioi T, Kato T, Inuzuka Y, Kawashima T, Tamaki Y, Kawamoto A, Tanada Y, Iwanaga Y, Narazaki M, Matsuda T, Adachi S, Soga T, Takemura G, Kondoh H, Kita T, Kimura T
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Journal Title
PLoS One
Volume: 8(8)
Pages: e72173
DOI
Related Report
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[Journal Article] Hepatocyte nuclear factor-1β promotes glucose uptake and glycolytic activity in ovarian clear carcinoma.2013
Author(s)
Takako Okamoto, Masaki Mandai, Noriomi Matsumura, Ken Yamaguchi, Hiroshi Kondoh, Yasuaki Amano, Tsukasa Baba, Junzo Hamanishi, Kaoru Abiko, Kenzo Kosaka, Susan K, Murphy, Seiichi Mori, Ikuo Konishi
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Journal Title
Molecular carcinogenesis
Volume: Sep 17
Pages: 1-15
DOI
Related Report
Peer Reviewed
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[Journal Article] Persistent overexpression of phosphoglycerate mutase, a glycolytic enzyme, modifies energy metabolism and reduces stress resistance of heart in mice.2013
Author(s)
Okuda J, Niizuma S, Shioi T, Kato T, Inuzuka Y, Kawashima T, Tamaki Y, Kawamoto A, Tanada Y, Iwanaga Y, Narazaki M, Matsuda T, Adachi S, Soga T, Takemura G, Kondoh H, Kita T, Kimura T
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Journal Title
PLoS One
Volume: 8
Pages: e2013
DOI
Related Report
Peer Reviewed
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[Journal Article] Impact of COPD exacerbations on osteoporosis assessed by chest CT scan2012
Author(s)
H Kiyokawa, S Muro, T Oguma, S Sato, N Tanabe, T Takahashi, M Kudo, D Kinose, H Kondoh, T Kubo, Y Hoshino, E Ogawa, T Hirai, and M Mishima
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Journal Title
COPD
Volume: 9
Pages: 1-8
Related Report
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