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Integrative neuroimaging study for self awareness and meta recognition system in alexithymia

Research Project

Project/Area Number 23390192
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionNational Center of Neurology and Psychiatry (2011-2013, 2015)
Gunma University (2014-2015)

Principal Investigator

Moriguchi Yoshiya  国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所 精神生理研究部, 客員研究員 (40392477)

Co-Investigator(Kenkyū-buntansha) KOMAKI Gen  国際医療福祉大学, 教授 (70225564)
KUMANO Hiroaki  早稲田大学, 教授 (90280875)
Project Period (FY) 2011-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Keywords心療内科学 / 心身症 / アレキシサイミア / 脳神経科学
Outline of Final Research Achievements

Alexithymia is an important psychopathology which manifests inability to identify self’s emotion and difficulty in expressing it. The aim of this study is to reveal neural basis of the relationship between body and mind status changes, using functional magnetic resonance imaging (fMRI). For self-continuity based on autobiographical information, we created web system to record everyday events and found that positive memories are more retained than negative ones, which involves hippocampus activities. We also measured brain activity with fMRI and concurrently heart rate variability (HRV) in response to emotional stimuli, and found insula and ventromedical prefrontal activity and connectivity were correlated with parasympathetic factor in HRV. Oversensitivity to interoceptive information increased anxiety and insula activity was decreased in alexithymia.

Report

(6 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (54 results)

All 2016 2015 2014 2013 2012 2011

All Journal Article (28 results) (of which Peer Reviewed: 22 results,  Open Access: 7 results,  Acknowledgement Compliant: 4 results) Presentation (24 results) (of which Invited: 2 results) Book (2 results)

  • [Journal Article] Neural basis of hierarchical visual form processing of Japanese Kanji characters.2015

    • Author(s)
      Higuchi H、 Moriguchi Y、 Murakami H、 Katsunuma R、 Mishima K、 Uno A
    • Journal Title

      Brain and Behavior

      Volume: 5(12) Issue: 12

    • DOI

      10.1002/brb3.413

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Attenuated sensitivity to the emotions of others by insular lesion.2015

    • Author(s)
      Terasawa, Y., Kurosaki, Y., Ibata, Y., Moriguchi, Y., & Umeda, S.
    • Journal Title

      Frontiers in Psychology

      Volume: 6 Pages: 1314-1314

    • DOI

      10.3389/fpsyg.2015.01314

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neural Networks for Mindfulness and Emotion Suppression.2015

    • Author(s)
      Murakami H, Katsunuma R, Oba K, Terasawa Y, Motomura Y, Mishima K, Moriguchi Y
    • Journal Title

      PLoS One

      Volume: 10(6) Issue: 6 Pages: e0128005-e0128005

    • DOI

      10.1371/journal.pone.0128005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Memory and reward systems coproduce ‘nostalgic’ experiences in the brain.2015

    • Author(s)
      Kentaro Oba, Madoka Noriuchi, Tomoaki Atomi, Yoshiya Moriguchi, Yoshiaki Kikuchi
    • Journal Title

      Social Cognitive and Affective Neuroscience

      Volume: 8 Issue: 7 Pages: 1069-1077

    • DOI

      10.1093/scan/nsv073

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modeling circadian and sleep-homeostatic effects on short-term interval timing.2015

    • Author(s)
      Spati J, Aritake S, Meyer AH, Kitamura S, Hida A, Higuchi S, Moriguchi Y,Mishima K.
    • Journal Title

      Frontiers in integrative neuroscience.

      Volume: 9 Pages: 1-9

    • DOI

      10.3389/fnint.2015.00015

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Activation of the prefrontal cortex while performing a task at preferred slow pace and metronome slow pace: a functional near-infrared spectroscopy study.2014

    • Author(s)
      Shimoda K, Moriguchi Y, Tsuchiya K, Katsuyama S, Tozato F.
    • Journal Title

      Neural plasticity.

      Volume: 2014 Pages: 1-7

    • DOI

      10.1155/2014/269120

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sleepiness induced by sleep-debt enhanced amygdala activity for subliminal signals of fear2014

    • Author(s)
      Motomura Y, Kitamura S, Oba K, Terasawa Y, Enomoto M, Katayose Y, Hida A, Moriguchi Y, Higuchi S, Mishima K
    • Journal Title

      BMC Neuroscience

      Volume: 15 Issue: 1 Pages: 97-97

    • DOI

      10.1186/1471-2202-15-97

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Basic Neuroscience 画像 fMRIによるニューロフィードバック2014

    • Author(s)
      守口善也
    • Journal Title

      Annual Review神経

      Volume: 1 Pages: 43-50

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Sex differences in the neural correlates of affective experience.2014

    • Author(s)
      Moriguchi Y, Touroutoglou A, Dickerson BC, Barrett LF.
    • Journal Title

      Social cognitive and affective neuroscience.

      Volume: in press Issue: 5 Pages: 8-8

    • DOI

      10.1093/scan/nst030

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interoceptive sensitivity predicts sensitivity to the emotions of others.2013

    • Author(s)
      Terasawa, Y., ほか3名
    • Journal Title

      Cognition and Emotion.

      Volume: (In press) Issue: 8 Pages: 1435-48

    • DOI

      10.1080/02699931.2014.888988

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anterior insular cortex mediates bodily sensibility and social anxiety.2013

    • Author(s)
      Terasawa Y., ほか3名
    • Journal Title

      Social Cognitive and Affective Neuroscience

      Volume: 8 Issue: 3 Pages: 259-266

    • DOI

      10.1093/scan/nss108

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activity in the action observation network enhances emotion regulation during observation of risk-taking: an fMRI study.2013

    • Author(s)
      Tamura M, Moriguchi Y, Higuchi S, Hida A, Enomoto M, Umezawa J, Mishima K.
    • Journal Title

      Neurol Res.

      Volume: 35(1) Issue: 1 Pages: 22-8

    • DOI

      10.1179/1743132812y.0000000109

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Higher cortisol levels at diurnal trough predict greater attentional bias towards threat in healthy young adults.2013

    • Author(s)
      Hakamata Y, Izawa S, Sato E, Komi S, Murayama N, Moriguchi Y, Hanakawa T, Inoue Y, Tagaya H.
    • Journal Title

      J Affect Disord

      Volume: 151(2) Issue: 2 Pages: 775-9

    • DOI

      10.1016/j.jad.2013.06.031

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sleep debt elicits negative emotional reaction through diminished amygdala-anterior cingulate functional connectivity2013

    • Author(s)
      Motomura Y., ほか9名
    • Journal Title

      PLoS One

      Volume: 8 Issue: 2 Pages: 1-10

    • DOI

      10.1371/journal.pone.0056578

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intrinsic Circadian Period of Sighted Patients with Circadian Rhythm Sleep Disorder, Free-Running Type2013

    • Author(s)
      Kitamura S.
    • Journal Title

      Biol Psychiatry

      Volume: 73(1) Issue: 1 Pages: 63-9

    • DOI

      10.1016/j.biopsych.2012.06.027

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rhythmic expression of circadian clock genes in human leukocytes and beard hair follicle cells2012

    • Author(s)
      Watanabe M.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 425(4) Issue: 4 Pages: 902-7

    • DOI

      10.1016/j.bbrc.2012.08.008

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neural Network Development in Late Adolescents during Observation of Risk-Taking Action2012

    • Author(s)
      Tamura M
    • Journal Title

      PloS one

      Volume: 7(6) Issue: 6 Pages: e39527-e39527

    • DOI

      10.1371/journal.pone.0039527

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discrimination of female schizophrenia patients from healthy women using multiple structural brain measures obtained with voxel-based morphometry2012

    • Author(s)
      Ota M, et al,
    • Journal Title

      Psychiatry and Clinical Neurosciences,

      Volume: 66 Issue: 7 Pages: 611

    • DOI

      10.1111/j.1440-1819.2012.02397.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] States of mind: Emotions, body feelings, and thoughts share distributed neural networks2012

    • Author(s)
      Oosterwijk S
    • Journal Title

      NeuroImage

      Volume: 62(3) Issue: 3 Pages: 2110-28

    • DOI

      10.1016/j.neuroimage.2012.05.079

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Individual traits and environmental factors influencing an individual's sleep timing : a study of 225 Japanese couples2012

    • Author(s)
      Hida A, Kitamura S, Enomoto M, Nozaki K, Moriguchi Y, Echizenya M, et al
    • Journal Title

      Chronobiol Int

      Volume: 29(2) Issue: 2 Pages: 3220-226

    • DOI

      10.3109/07420528.2011.641045

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Daily physical complaints and hippocampal function: An fMRI study of pain modulation by anxiety.2012

    • Author(s)
      Gondo M
    • Journal Title

      NeuroImage

      Volume: 63(3) Issue: 3 Pages: 1011-9

    • DOI

      10.1016/j.neuroimage.2012.07.025

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 認知行動療法から神経行動療法へ ニューロフィードバック2012

    • Author(s)
      守口善也
    • Journal Title

      臨床心理学

      Volume: 13(2) Pages: 222-6

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 【認知/行動療法の技法と治療効果】 ニューロフィードバックとCBT2012

    • Author(s)
      守口善也
    • Journal Title

      臨床精神医学

      Volume: 41(8) Pages: 1031-36

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Source Imaging during two Qigong Meditations2012

    • Author(s)
      Faber PL, Lehmann D, Tei S, Tsujiuchi T, Kumano H, Pascual-Marqui RD, Kochi K
    • Journal Title

      Cognitive Processing

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential hemodynamic response in affective circuitry with aging : an FMRI study of novelty, valence, and arousal2011

    • Author(s)
      Moriguchi Y, Negreira A, Weierich M, Dautoff R, Dickerson BC, Wright CI, Barrett LF
    • Journal Title

      J Cogn Neurosci

      Volume: 23 Issue: 5 Pages: 1027-1041

    • DOI

      10.1162/jocn.2010.21527

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アレキシサイミアと感情認知の脳機能画像解析-社会性の観点から2011

    • Author(s)
      守口善也
    • Journal Title

      認知神経科学

      Volume: 13 Pages: 37-45

    • NAID

      130006895674

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 間合い、間を読む科学心身医学と、自己・他者の心の理解の脳科学2011

    • Author(s)
      守口善也
    • Journal Title

      心身健康科学

      Volume: 7 Pages: 10-16

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Neuroimagingの新展開;アレキシサイミアの脳画像研究2011

    • Author(s)
      守口善也
    • Journal Title

      心身医学

      Volume: 51 Pages: 141-150

    • Related Report
      2011 Annual Research Report
  • [Presentation] リアルタイムfMRI による、情動調節に関するフィードバックトレーニングの開発2016

    • Author(s)
      守口 善也
    • Organizer
      第8回日本不安症学会学術大会
    • Place of Presentation
      千葉県千葉市 千葉大学亥鼻キャンパス
    • Year and Date
      2016-02-06
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 身体感覚への気づきに関わる神経基盤の研究2013

    • Author(s)
      守口善也, 村上裕樹, 勝沼るり, 寺澤悠理, 大場健太郎, 金山裕介, 三島和夫, 松田博史, 岡孝和
    • Organizer
      第 54 回日本心身医学会総会ならびに学術講演会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Stress hormone and neuropsychological functioning predict attention bias towards threat in healthy individuals.2013

    • Author(s)
      Hakamata Y, Izawa S, Sato E, Komi S, Murayama N, Moriguchi Y, Hanakawa T, Inoue Y, Tagaya H
    • Organizer
      The 21st European Congress of Psychiatry
    • Place of Presentation
      Nice - Acropolis Nice, France
    • Related Report
      2013 Annual Research Report
  • [Presentation] 社会不安と内受容感覚を媒介する島皮質前部の活動2013

    • Author(s)
      寺澤悠理
    • Organizer
      平成24年度生理研研究会 第2回社会神経科学研究会 「社会の中で生きる心の理解」
    • Place of Presentation
      生理学研究所, 岡崎, 愛知
    • Related Report
      2012 Annual Research Report
  • [Presentation] THE NEURAL SUBSTRATES OF THE EMOTIONAL AUTOBIOGRAPHICAL MEMORY RETRIEVAL AND ITS RELATION TO ADAPTIVE COPING2013

    • Author(s)
      K. Oba
    • Organizer
      The 71st Annual Meeting of the American Psychosomatic Society
    • Place of Presentation
      InterContinental Miami, Miami, FL
    • Related Report
      2012 Annual Research Report
  • [Presentation] NEURAL BASIS FOR AUTOGENIC TRAINING2013

    • Author(s)
      H. Murakami
    • Organizer
      The 71st Annual Meeting of the American Psychosomatic Society
    • Place of Presentation
      InterContinental Miami, Miami, FL
    • Related Report
      2012 Annual Research Report
  • [Presentation] SLEEPINESS BY SLEEP DEBT ENHANCED AMYGDALA ACTIVATION FOR SUBLIMINAL SIGNALS OF FEAR2013

    • Author(s)
      Y. Motomura
    • Organizer
      The 71st Annual Meeting of the American Psychosomatic Society
    • Place of Presentation
      InterContinental Miami, Miami, FL
    • Related Report
      2012 Annual Research Report
  • [Presentation] Neurofeedback-guided Mindfulness-based Attention Training with Real time FMRI2013

    • Author(s)
      Y. Moriguchi
    • Organizer
      Symposium135: New Innovations in Neuroimaging of Autonomic Regulation in The 71st Annual Scientific Meeting of American Psychosomatic Society
    • Place of Presentation
      InterContinental Miami, Miami, FL
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] APPLICATION OF REAL-TIME FMRI TO COCKROACH PHOBIA2013

    • Author(s)
      Y. Moriguchi
    • Organizer
      71st Annual Scientific Meeting, American Psychosomatic Society
    • Place of Presentation
      InterContinental Miami, Miami, FL
    • Related Report
      2012 Annual Research Report
  • [Presentation] WHY SLEEP DEPRIVATION RISK US OBESITY? AN FMRI STUDY2013

    • Author(s)
      R. Katsunuma
    • Organizer
      The 71st Annual Meeting of the American Psychosomatic Society
    • Place of Presentation
      InterContinental Miami, Miami, FL
    • Related Report
      2012 Annual Research Report
  • [Presentation] AUTISTIC TRAITS AFFECT NEURAL CORRELATES OF VISUOSPATIAL PERSPECTIVE TAKING2013

    • Author(s)
      Y. Kanayama
    • Organizer
      The 71st Annual Meeting of the American Psychosomatic Society
    • Place of Presentation
      InterContinental Miami, Miami, FL
    • Related Report
      2012 Annual Research Report
  • [Presentation] Neural basis for the mindful coping for affective pictures2012

    • Author(s)
      H.Murakami, Y.Moriguchi, A.Hida, K.Mishima
    • Organizer
      The 70th Annual Meeting of the American Psychosomatic Society
    • Place of Presentation
      Hilton, Athens, Greece
    • Year and Date
      2012-03-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neural correlates of differences of affective experience between men and women Neural correlates of differences of affective experience between men and women2012

    • Author(s)
      Y.Moriguchi, A.Touroutoglou, R.Dautoff, B.C.Dickerson, Y.Terasawa, K.Oba, K.Mishima, L.F.Barrett
    • Organizer
      The 70th Annual Meeting of the American Psychosomatic Society
    • Place of Presentation
      Hilton, Athens, Greece
    • Year and Date
      2012-03-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] The neural substrates of positive emotion induction associated with remote autobiographical memory2012

    • Author(s)
      K.Oba, M.Noriuchi, A.Matsuoka, Y.Terasawa, Y.Kanayama, Y.Moriguchi, K.Mishima, Y.Kikuchi
    • Organizer
      The 70th Annual Meeting of the American Psychosomatic Society
    • Place of Presentation
      Hilton, Athens, Greece
    • Year and Date
      2012-03-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] THE INVOLVEMENT OF ANTERIOR INSULAR CORTEX IN SOCIAL ANXIETY AND INTEROCEPTIVE SENSIBILITY2012

    • Author(s)
      Y. Terasawa
    • Organizer
      Cognitive Neuroscience Society 2012 Annual Meeting
    • Place of Presentation
      The Palmer House, Chicago, IL
    • Related Report
      2012 Annual Research Report
  • [Presentation] Anterior insular cortex mediates bodily sensibility and social anxiety2012

    • Author(s)
      Y. Terasawa
    • Organizer
      International Society for Affective Disorder
    • Place of Presentation
      The Royal College of Physicians, London, UK
    • Related Report
      2012 Annual Research Report
  • [Presentation] Emotional sensibility and accuracy of interoceptive awareness2012

    • Author(s)
      Y. Terasawa
    • Organizer
      the 16th World Congress of the International Organization of Psychophysiology
    • Place of Presentation
      Polo Didattico Porta Nuova, Pisa, Italy
    • Related Report
      2012 Annual Research Report
  • [Presentation] MAPPING THE MIND: A CONSTRUCTIONIST VIEW ON HOW MENTAL STATES EMERGE FROM THE BRAIN2012

    • Author(s)
      S. Oosterwijk
    • Organizer
      Cognitive Neuroscience Society - 2012 Annual Meeting
    • Place of Presentation
      The Palmer House, Chicago, IL
    • Related Report
      2012 Annual Research Report
  • [Presentation] Neural correlates of body dissatisfaction: A Functional MRI study.2012

    • Author(s)
      N. Kodama
    • Organizer
      The 15th Congress of Asian College Psychosomatic Medicine
    • Place of Presentation
      Chinggis khaan hotel, Ulaanbaatar, Mongolia
    • Related Report
      2012 Annual Research Report
  • [Presentation] Neural basis for human sensitivity to emotional changes of facial expression : An fMRI study2011

    • Author(s)
      Y.Moriguchi, G.Komaki, A.Hida, K.Mishima
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      Walter E.Washington Convention Center, Washington, DC
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mapping the mind : A constructionist view on how mental states emerge from the brain2011

    • Author(s)
      Oosterwijk, K., A.Lindquist, E.Anderson, R.Dautoff, Y.Moriguchi, L.F.Barrett
    • Organizer
      The Society for Social Neuroscience 2011 Annual Meeting
    • Place of Presentation
      Walter E.Washington Convention Center, Washington, DC
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Perspectives on the future of alexithymia research based on recent fMRI and self-report alexithymia investigations2011

    • Author(s)
      G.Komaki
    • Organizer
      15th World Congress of Psychiatry : Regular Symposium 71 : The alexithymia construct : history, recent developments and future directions
    • Place of Presentation
      Sheraton Buenos Aires Hotel & Convention Center, Buenos Aires/Argentina(招待講演)
    • Year and Date
      2011-09-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Social Neuroscience of Alexithymia2011

    • Author(s)
      Y.Moriguchi
    • Organizer
      The 21st World Congress on Psychosomatic Medicine : Symposium : Alexisomia : A Shift in Focus from Alexithymia
    • Place of Presentation
      National Museum of Korea, Seoul, Korea(招待講演)
    • Year and Date
      2011-08-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Validity Issues in the Assessment of Alexithymia2011

    • Author(s)
      G.Komaki
    • Organizer
      The 21st World Congress on Psychosomatic Medicine : Symposium : Alexisomia : A Shift in Focus from Alexithymia
    • Place of Presentation
      National Museum of Korea, Seoul, Korea(招待講演)
    • Year and Date
      2011-08-25
    • Related Report
      2011 Annual Research Report
  • [Book] 1 アレキシサイミアと社会脳. 自己を知る脳・他者を理解する脳 ――神経認知心理学からみた心の理論の新展開2014

    • Author(s)
      守口善也
    • Total Pages
      320
    • Publisher
      新曜社
    • Related Report
      2014 Annual Research Report
  • [Book] 心身相関医学の最新知識2012

    • Author(s)
      熊野宏昭:久保木富房・久保千春・野村忍, 不安・抑うつ臨床研究会編
    • Publisher
      日本評論社(印刷中)
    • Related Report
      2011 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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