Development of new diagnosis approaches for detecting cardiovascular dysfunction in patients with respiratory disease using positron emission tomography
| Project/Area Number |
23390294
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATOH Chietsugu 北海道大学, 保健科学研究院, 教授 (10292012)
TSUJINO Ichizo 北海道大学, 北海道大学病院, 講師 (00344507)
MANABE Noriko 北海道大学, 北海道大学病院, 講師 (70463742)
西嶋 剣一 北海道大学, 医学(系)研究科(研究院), 特任講師 (60364254)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
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| Keywords | 核医学 / 肺高血圧症 / 心サルコイドーシス / 心筋代謝 / 心筋炎症 / 交感神経機能 / 内科系臨床医学 / 放射線科学 |
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| Research Abstract |
Right ventricular (RV) oxidative metabolism increased in patients with PH in association with prognostic markers such as mean PAP, PVR, and BNP.. Patients with WHO functional class II to III PH also had increased RV power and efficiency. These findings may indicate a myocardial energetics adaptation response to increasing PAP. Intensive PH treatments reduced RV oxidative metabolism and improved RV volume/oxygen consumption index. In this project, we developed possible new prognostic markers and useful treatment monitor markers in patients with PH.
F-18 flucorodeoxyglucose (FDG) has been considered to be a diagnostic marker of cardiac involvement sarcoidosis (CS). We reported the association between the ECG abnormalities and positive F-18 FDG uptake in LV. This indicates active inflammation is associated with rhythm abnormalities. We also reported the reduced cardiac sympathetic nervous function in CS. These findings may contribute the understanding the disease mechanisms.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Attenuated right ventricular energetics evaluated using C-11 acetate PET in patients with pulmonary hypertension2014
Author(s)
Yoshinaga K, Ohira H, Tsujino I, Oyama-Manabe N, Mielniczuk L, Beanlands R, Katoh C, Kasai K, Manabe O, Sato T, Fujii S, Ito Y, Tomiyama Y, Nishimura M, Tamaki N
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Journal Title
Eur J Nucl Med Mol Imaging
Volume: 41
Pages: 1240-50
Related Report
Peer Reviewed
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[Journal Article] Electrocardiographically gated 11C-hydroxyephedrine PET for the simultaneous assessment of cardiac sympathetic and contractile functions2014
Author(s)
Magota K, Hattori N, Manabe O, Naya M, Oyama-Manabe N, Shiga T, Kuge Y, Yamada S, Sakakibara M, Yoshinaga K, Tamaki N
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Journal Title
Ann Nucl Med
Volume: 3
Pages: 187-95
Related Report
Peer Reviewed
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[Journal Article] Interrelation between myocardial oxidative metabolism and diastolic function in patients undergoing surgical ventricular reconstruction2013
Author(s)
Chiba S, Naya M, Iwano H, Yoshinaga K, Katoh C, Manabe O, Yamada S, Wakasa S, Kubota S, Matsui Y, Tamaki N, Tsutsui H
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Journal Title
Eur J Nucl Med Mol Imaging
Volume: 40
Pages: 349-355
Related Report
Peer Reviewed
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[Journal Article] Quantification of regional myocardial blood flow estimation with three-dimensional dynamic rubidium-82 PET and modified spillover correction model2012
Author(s)
Katoh C, Yoshinaga K, Klein R, Kasai K, Tomiyama Y, Manabe O, Naya M, Sakakibara M, Tsutsui H, deKemp RA, Tamaki N
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Journal Title
J Nucl Cardiol
Volume: 19:4
Pages: 763-74
Related Report
Peer Reviewed
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[Journal Article] Effects of surgical ventricular reconstruction and mitral complex reconstruction on cardiac oxidative metabolism and efficiency innNonischemic and ischemic dilated cardiomyopathy2011
Author(s)
Sugiki T, Naya M, Manabe O, Wakasa S, Kubota S, Chiba S, Iwano H, Y amada S, Y oshinaga K, T amaki N, T sutsui H, Matsui Y
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Journal Title
JACC Cardiovasc Ima
Volume: 4
Pages: 762-70
Related Report
Peer Reviewed
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