| Project/Area Number |
23390298
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
DEMACHI Kazuyuki 東京大学, 大学院・工学系研究科(工学部), 准教授 (00292764)
MASUTANI Yoshitaka 東京大学, 医学部附属病院, 講師 (20345193)
SAKUMI Akira 東京大学, 医学部附属病院, 特任助教 (30360556)
HAGA Akihiro 東京大学, 医学部附属病院, 助教 (30448021)
NISHIO Teiji 独立行政法人国立がん研究センター, 臨床開発センター, ユニット長 (40415526)
SHIRAISHI Kenshiro 東京大学, 医学部附属病院, 助教 (40447404)
YAMASHITA Hideomi 東京大学, 医学部附属病院, 助教 (70447407)
IGAKI Hiroshi 東京大学, 医学部附属病院, 講師 (90361344)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2011: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Keywords | VMAT / コーンビーム CT / 呼吸性移動 / 4D-CT / IMRT / VMAT-CT / radiation therapy / radiotherapy / コーンビームCT / adaptive radiotherapy / adaptive radiation therapy |
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| Research Abstract |
In this study, we have developed in-treatment kilo-voltage four-dimensional cone-beam CT (in-treatment kV 4D CBCT) acquisition during volumetric modulated arc therapy (VMAT) by use of the image-based phase recognition technique of projection images. With the in-treatment kV 4D CBCT, the respiratory motion of lung tumors has been quantitatively evaluated for the first time, and the margin applied in treatment planning has been retrospectively reanalyzed. In addition, the CBCT reconstruction using the portal images of VMAT beam and its four dimensional version (4D VMAT CBCT) have been developed. With the 4D VMAT CBCT, the tumor location and movement were visually observed. Combining 4D VMAT CBCT with in-treatment kV 4D CBCT, it is expected that the appropriate margin setting and the reduction of the extra-radiation dose for normal tissue are achieved.
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