| Project/Area Number |
23390324
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SHIMADA Mitsuo 徳島大学, ヘルスバイオサイエンス研究部, 教授 (10216070)
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| Co-Investigator(Kenkyū-buntansha) |
YASUTOMO Koji 徳島大学, ヘルスバイオサイエンス研究部, 教授 (30333511)
TANAKA Shinji 東京医科歯科大学, 情報処理センター, 科学技術振興特別特認准教授 (30253420)
IMURA Satoru 徳島大学, 病院, 助教 (90380021)
MORINE Yuji 徳島大学, 病院, 助教 (60398021)
TAKEDA Eiji 徳島大学, ヘルスバイオサイエンス研究部, 教授 (00144973)
UTSUNOMIYA Toru 徳島大学, ヘルスバイオサイエンス研究部, 准教授 (30304801)
IKEMOTO Tetsuya 徳島大学, ヘルスバイオサイエンス研究部, 助教 (20398019)
KATAGIRI Toyomasa 徳島大学, 疾患プロテオゲノム研究センター, 教授 (60291895)
OYADOMARI Seiichi 徳島大学, 疾患プロテオゲノム研究センター, 教授 (90502534)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2011: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | 肝不全 / 加齢肝 / 幹細胞 / 加齢遺伝子 / マイクロダイアライシス |
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| Research Abstract |
The majority of liver transplantation in Japan is living donor liver transplantation. As aging population has recently been increasing, aged liver of a donor candidate has become a most problem. We gave similar surgical insults as liver transplantation, including ischemia-reperfusion injury and massive hepatectomy in the aged liver. We obtained several novel findings regarding the mechanisms, by which aging induced liver functional and regenerative insufficiency. We also found some possible therapeutic agents and strategies including ADRC, HDAC inhibitor and the others, which may improve the liver dysfunction and may support liver regeneration in these animal models.
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