| Project/Area Number |
23390331
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
YAMAUE HIROKI 和歌山県立医科大学, 医学部, 教授 (20191190)
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| Co-Investigator(Kenkyū-buntansha) |
IWAHASHI Makoto 和歌山県立医科大学, 医学部, 非常勤講師 (70244738)
TANI Masaji 和歌山県立医科大学, 医学部, 准教授 (60236677)
NAKAMORI Mikihito 和歌山県立医科大学, 医学部, 講師 (10322372)
KAWAI Manabu 和歌山県立医科大学, 医学部, 講師 (40398459)
HIRONO Seiko 和歌山県立医科大学, 医学部, 助教 (60468288)
MIYAZAWA Motoki 和歌山県立医科大学, 医学部, 学内助教 (90549734)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 膵癌治療 / ペプチド / ワクチン / 補助化学療法 / 膵癌 / 2方向性新規ペプチドワクチン療法 / VEGFR2 / VEGFR1 / MUC-16 / mesothelin / 免疫療法 / 2方法性新規ペプチドワクチン療法 / ペプチドワクチン / VEGFR-1 / VEGFR-2 / MUC16 |
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| Research Abstract |
1. We apply cocktail vaccine for pancreatic cancer patient who is positive for HLA-A*0201 which target on VEGFR1/VEGFR2/KIF20A in a clinical setting. Next stage, we will identify and product a new target molecular target, oncoantigen; epitope peptide of MUC-16, mesothelin, ensure the safety and stability, and have started Phase I study.
2. As the applicance of peptide vaccine therapy with Gemicitabine based adjuvant chemotherapy, many patients presented and apply for other clinical study, new procedure and postoperative management has been established. As a result, the incidence of postoperative complication has been decreased, and the time between operation and adjuvant chemotherapy was gradually shortened.
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