Surgical Therapy for the neuropathic pain.
Project/Area Number |
23390375
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Anesthesiology/Resuscitation studies
|
Research Institution | Kyoto University |
Principal Investigator |
INADA Yuji 京都大学, 再生医科学研究所, 非常勤講師 (90254515)
|
Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Tatsuo 京都大学, 再生医科学研究所, 准教授 (70227908)
|
Project Period (FY) |
2011-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2011: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
|
Keywords | カウザルギー / 神経因性疼痛 / 慢性疼痛 / 人工神経 / アロデニア / コラーゲン / CRPS / 難治性疼痛 / 末梢神経 / 神経再生 / 神経障害性痛 / 生体内再生治療 / 総和仮説 |
Research Abstract |
Animal experimental model was made in Beagle dogs on the neuropathic pain. Using this mode the mechanism was studied concerning the surgical approach which refers the local and central nerve systems with electrophysiological and pathological, biochemical methods to reveal the main reason of on-set of the neuropathic pain. We have already found in clinically that the local recovery of the peripheral nerve reads to reduce the neuropathic pain, the study revealed one part of this mechanism. Since the animal model of a neuropathic pain was established by ligation of the peripheral nerve, we applied it for the sciatic nerve of Beagle dogs as a model of the neuropathic nerve. For the new treatment, we challenged to replace the damaged site with a nerve conduit composed of PGA and collagen and evaluated nether peripheral repair may contribute the morbus of the neuropathic pain.
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Report
(4 results)
Research Products
(179 results)
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[Journal Article] A novel surgical marking system for small peripheral lung nodules based on radio frequency identification technology : Feasibility study in a canine model2014
Author(s)
Kojima, F., Sato, T., Takahata, H., Okada, M., Sugiura, T., Oshiro, O., Date, H., Nakamura, T
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Journal Title
J Thorac Cardiovasc Surg
Volume: 147
Issue: 4
Pages: 1384-9
DOI
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Peer Reviewed / Open Access
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[Journal Article] Survival and treatments in patients with incompletely resected thymoma.2014
Author(s)
Hamaji, M., Omasa, M., Chen, F., Yamada, T., Sato, M., Menju, T., Sato, T., Aoyama, A., Sonobe, M., Bando, T., Date, H.
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Journal Title
Asian Thoracic and Cardiovascular Annals.
Volume: in press
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Peer Reviewed
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[Journal Article] Regeneration of Canine Inferier Alveolar Nerve by Polyglycolic Acid-Collagen Tube with Platelet Rich Plasma2013
Author(s)
Shigeno, K., Kaneko, M., Wakatsuki, M., Nakada, A., Hashimoto, Y., Honda, M., Inada, Y., Nakamura, T
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Journal Title
Int J Artif Organs
Volume: 36
Pages: 571-571
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Peer Reviewed
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[Journal Article] Improvement of eustachian tube function by Tissue-Engineered regeneration of mastoid air cells2013
Author(s)
Kanemaru, S., Umeda, H., Yamashita, M., Hiraumi, H., Hirano, S., Nakamura, T., Ito, J
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Journal Title
Laryngoscope
Volume: 123
Issue: 2
Pages: 472-476
DOI
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Peer Reviewed
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[Journal Article] Protracted delay in taste sensation recovery after surgical lingual nerve repair : a case report2013
Author(s)
Seo, K., Inada, Y., Terumitsu, M. Nakamura, T., Shigeno, K., Tanaka, Y., Tsurumaki, T., Kurata, S., Matsuzawa, H
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Journal Title
Journal of Medical Case Reports
Volume: 7
Issue: 1
Pages: 77-81
DOI
Related Report
Peer Reviewed
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[Journal Article] Regeneration of Canine Inferier Alveolar Nerve by Polyglycolic Acid-Collagen Tube with Platelet Rich Plasma.2013
Author(s)
Shigeno, K., Kaneko, M., Wakatsuki, M., Nakada, A., Hashimoto, Y., Honda, M., Inada, Y., Nakamura, T.
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Journal Title
Int J Artif Organs.
Volume: 36
Pages: 571-571
Related Report
Peer Reviewed
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[Journal Article] Transforming Growth Factor/33 for the prevention of vocal fold scarring2012
Author(s)
Ohno, S., Hirano, S., Kanemaru, S., Kitani, Y., Kojima, T., Ishikawa, S., Mizuta, M., Tateya, I., Nakamura, T., Ito, J.
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Journal Title
Laryngoscope
Volume: 122
Issue: 3
Pages: 583-589
DOI
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[Journal Article] Regeneration of canine inferior alveolar nerve by polyglycolic acid-collagen tube2012
Author(s)
Shigeno, k., Nakada, A., Kaneko, M., Wakatsuki, M., Hashimoto, Y., Inada, Y., Nakamura, T
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Journal Title
Int Artif Organs
Volume: 35(8)
Pages: 569-569
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[Journal Article] Promotion of bone repairing by use of novel Collagen scaffold in Rabbit skull defect model2012
Author(s)
Wakatsuki, M., Kaneko, M., Sasauchi, K., Nakada, A., Shigeno, K., Nakamura, T
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Journal Title
Int Artif Organs
Volume: 35(8)
Pages: 591-591
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[Journal Article] Artificial trachea and In situ tissue engineering : twelve gean-follow up.in canine model2012
Author(s)
Nakamura, T., Fumitsugu, K., Sato, T., Nakada, A., Wakatsuki, M., Sasauchi, K., Kida, N., Kanemaru, S., Omori, K., Kaneko, M., Shigeno, k., Inada, Y., Endo, K
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Journal Title
Int Artif Organs
Volume: 35(8)
Pages: 608-608
Related Report
Peer Reviewed
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[Journal Article] Role of Circulating Mesenchymal Stem Cells in Vocal Fold Wound Healing2012
Author(s)
Ohno, S., Hirano, S., Kanemaru, S., Mizuta, M., Ishikawa, S., Tateya, I., Nakamura, T., Ito, J
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Journal Title
Laryngoscope
Volume: 122(11)
Issue: 11
Pages: 2503-2510
DOI
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Peer Reviewed
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[Journal Article] Increased expression of phosphatidylcholine (16:0/18:1) and (16:0/18:2) in thyroid papillary cancer2012
Author(s)
Ishikawa, S., Tateya, I., Hayakawa, T., Masaki, N., Takizawa, Y., Ohno, S., Kojima, T., Kitani, Y., Kitamura, M., Hirano, S., Setou, M., Ito, J
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Journal Title
PLoS One
Volume: 7(11)
Issue: 11
Pages: e48873-e48873
DOI
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Peer Reviewed
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[Journal Article] Implantation of an atelocollagen sponge with autologous bone marrow-derived mesenchymal stromal cells for treatment of vocal fold scarring in a canine model2011
Author(s)
Ohno, S., Hirano, S., Kanemaru, S., Kitani, Y., Kojima, T., Tateya, I.Nakamura, T., Ito, J
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Journal Title
Ann Otol Rhinol Laryngol
Volume: 120
Pages: 401-408
Related Report
Peer Reviewed
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[Journal Article] Prevention of buccal mucosa scarring with transforming growth factor 3 32011
Author(s)
Ohno, S., Hirano, S., Kanemaru, S., Tateya, I., Kitani, Y., Kojima, T., Nakamura, T., Ito, J.
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Journal Title
Laryngoscope
Volume: 121
Issue: 7
Pages: 1404-1409
DOI
Related Report
Peer Reviewed
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[Journal Article] Feasibility study of corticosteroid treatment for esophageal ulcer after EMR in a canine model2011
Author(s)
Honda, M., Nakamura, T., Hori, Y., Shionoya, Y., Yamamoto, K., Nishizawa, Y., Kojima, F., Shigeno, K.
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Journal Title
Journal of Gastroenterology
Volume: 46
Issue: 7
Pages: 866-872
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Development of a novel ant adhesive material, alginate flakes, ex vivo and in vivo2011
Author(s)
Hirasaki, Y., Fukunaga, M., Kidokoro, A., Hashimoto, A., Nakamura, T., Tsujimoto, H., Hagiwara, A.
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Journal Title
Surg today
Volume: 41
Issue: 7
Pages: 970-977
DOI
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Peer Reviewed
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[Journal Article] Regeneration of radiation damaged salivary glands with adipose-derived stromal cells2011
Author(s)
Kojima, T., Kanemaru, S., Hirano, S., Tateya, I., Ohno, S., Nakamura, T., Ito, J.
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Journal Title
Laryngoscope
Volume: 121
Issue: 9
Pages: 1864-1869
DOI
Related Report
Peer Reviewed
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[Journal Article] The protective efficacy of basic fibroblast growth factor in radiation-induced salivary gland dysfunction in mice2011
Author(s)
Kojima, T., Kanemaru, S., Hirano, S., Tateya, I., Suehiro, A., Kitani, Y., Kishimoto, Y., Ohno, S., Nakamura, T., Ito, J.
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Journal Title
Laryngoscope
Volume: 121
Issue: 9
Pages: 1870-1875
DOI
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[Journal Article] Reduction of air leaks in a canine model of pulmonary resection with a new staple-line buttress2011
Author(s)
Hashimoto, A., Kuwabara, M., Hirasaki, Y., Tsujimoto, H., Torii, T., Nakamura, T., Hagiwara, A.
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Journal Title
J Thorac Cardiovasc Surg
Volume: 142
Issue: 2
Pages: 366-371
DOI
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Peer Reviewed
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[Journal Article] Survival and treatments in patients with incompletely resected thymoma
Author(s)
Hamaji, M., Omasa, M., Chen, F., Yamada, T., Sato, M., Menju, T., Sato, T., Aoyama, A., Sonobe, M., Bando, T., Date, H
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Journal Title
Asian Thoracic and Cardiovascular Annals
Volume: (in press)
Related Report
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[Presentation] Experimental study of new vascularized composite allotransplantation : Anorectal transplantation with rats, dogs and human cadavers. 11th Meeting of the International Hand and Composite Tissue2013
Author(s)
Araki, J., Nishizawa, Y., Sato, T., Naito, M., Akita, K., Tashiro, K., Iida, T., Koshima, I
Organizer
Allotransplantation Society
Place of Presentation
Wroctaw
Year and Date
2013-08-29
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[Presentation] Anorectal transplantation research for the stoma patients2013
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Organizer
6th European Plastic Surgery Research Council
Place of Presentation
Hamburg
Year and Date
2013-08-22
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[Presentation] Anorectal transplantation research with rats, dogs and human cadavers2013
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Organizer
World Society of Reconstructive Microsurgery 2013 Congress
Place of Presentation
Chicago
Year and Date
2013-07-11
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[Presentation] In-Vivo Localization of Micro Radio Frequency Identification Tag : Concept Proof of Novel Surgical Marking System for Small Peripheral Lung Nodule2013
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Kojima, F., Sato, T., Takahata, H., Okada, M., Sugiura, T., Oshiro, O., Date, H., Nakamura. T
Organizer
第21回アジア胸部心臓血管外科学会
Place of Presentation
神戸
Year and Date
2013-04-06
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[Presentation] Novel tracheal prosthesis using in situ Tissue Engineering2013
Author(s)
Nakamura, T., Kojima, F., Sato, T., Hamaji, M., Kaneko, M., Kanemaru, S., Nakada, A., Omori, K., Shigeno, K., Wakatsuki, M., Endo, K
Organizer
40th Annual ESAO Congress
Place of Presentation
Scotland
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[Presentation] Regeneration of Canine Inferier Alveolar Nerve by Polyglycolic Acid-Collagen Tube with Platelet Rich Plasma2013
Author(s)
Shigeno, K., Kaneko, M., Wakatsuki, M., Nakada, A., Hashimoto, Y., Honda, M., Inada, Y., Nakamura, T
Organizer
40th Annual ESAO Congress
Place of Presentation
Scotland
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[Presentation] The effect of astaxanthin on vocal fold wound healing2013
Author(s)
Mizuta, M., Hirano, S., Tateya, I., Hiwatashi, N., Kanemaru, S. Ito, J
Organizer
The 134th American Laryngological Association
Place of Presentation
Orlando
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[Presentation] Impact of Transmission Power Variation to the Position Estimation Error Performance of RFID-tag Assisted Surgery Support System2013
Author(s)
Takahata, H., Sugiura, T., Kojima, F., Sato, T., Okada, M., Oshiro, O
Organizer
International Conference of the IEEE Engineering in Medicine and Biology Society(EMBC'2013)
Place of Presentation
Osaka
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[Presentation] Novel tracheal prosthesis using in situ Tissue Engineering.2013
Author(s)
Nakamura, T., Kojima, F., Sato, T., Hamaji, M., Kaneko, M., Kanemaru, S., Nakada, A., Omori, K., Shigeno, K., Wakatsuki, M., Endo, K.
Organizer
40th Annual ESAO Congress
Place of Presentation
Scotland (UK)
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[Presentation] Regeneration of Canine Inferier Alveolar Nerve by Polyglycolic Acid-Collagen Tube with Platelet Rich Plasma.2013
Author(s)
Shigeno, K., Kaneko, M., Wakatsuki, M., Nakada, A., Hashimoto, Y., Honda, M., Inada, Y., Nakamura, T.
Organizer
40th Annual ESAO Congress
Place of Presentation
Scotland (UK)
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[Presentation] The effect of astaxanthin on vocal fold wound healing.2013
Author(s)
Mizuta, M., Hirano, S., Tateya, I., Hiwatashi, N., Kanemaru, S. Ito, J.
Organizer
The 134th American Laryngological Association
Place of Presentation
Orlando (USA)
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[Presentation] Impact of Transmission Power Variation to the Position Estimation Error Performance of RFID-tag Assisted Surgery Support System.2013
Author(s)
Takahata, H., Sugiura, T., Kojima, F., Sato, T., Okada, M., Oshiro, O.
Organizer
International Conference of the IEEE Engineering in Medicine and Biology Society(EMBC'2013)
Place of Presentation
Osaka
Related Report
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[Presentation] Role of Circulating Mesenchymal Stem Cells in Vocal Fold Wound Healing2012
Author(s)
Ohno, S., Hirano, S., Kanemaru, S., Mizuta, M., Ishikawa, S., Tateya, I., Nakamura, T., Ito, J
Organizer
The 92nd Annual Meeting of The American Broncho-Esophagological Association
Place of Presentation
San Diego (USA)
Year and Date
2012-04-19
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[Presentation] PROMOTION OF BONE REPAIRING BY USE OF NOVEL COLLAGEN SCAFFOLDS IN RABBIT SKULL DEFECT MODEL2012
Author(s)
Wakatsuki, M., Kaneko, M., Sasauchi, K., Nakada, A., Shigeno, K., Nakamura, T
Organizer
39th Annual ESAO Congress
Place of Presentation
Rostock (Germany)
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[Presentation] REGENERATION OF CANINE INFERIER ALVEOLAR NERVE BY POLGLY-COLIC ACID-COLLAGEN TUBE2012
Author(s)
Shigeno, K., Shionoya, Y., Nakada, A., Kaneko, M., Wakatsuki, M., Hashimoto, Y., Inada, Y., Nakamura, T
Organizer
39th Annual ESAO Congress
Place of Presentation
Rostock (Germany)
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[Presentation] Transforming Growth Factor beta3 for the prevention of vocal fold scarring2011
Author(s)
Ohno, S., Hirano, S., Kanemaru, S., Tateya, I., Kada, S., Ito, J
Organizer
The Voice Foundation's 40th Annual Symposium : Care of the Professional Voice
Place of Presentation
Philadelphia (USA)
Year and Date
2011-06-02
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[Presentation] In-Vivo Localization of Micro Radio Frequency Identification Tag: Concept Proof of Novel Surgical Marking System for Small Peripheral Lung Nodule.
Author(s)
Kojima, F., Sato, T., Takahata, H., Okada, M., Sugiura, T., Oshiro, O., Date, H., Nakamura. T.
Organizer
第21回アジア胸部心臓血管外科学会
Place of Presentation
神戸
Related Report
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[Presentation] Experimental study of new vascularized composite allotransplantation: Anorectal transplantation with rats, dogs, and human cadavers.
Author(s)
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Organizer
11th Meeting of the International Hand and Composite Tissue Allotransplantation Society
Place of Presentation
Wroctaw (Republic of Poland)
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[Presentation] Anorectal transplantation research for the stoma patients.
Author(s)
Araki. J., Nishizawa, Y., Sato, T., Naito, M., Akita, K., Tashiro, K., Iida, T., Koshima, I.
Organizer
6th European Plastic Surgery Research Council
Place of Presentation
Hamburg (Germany)
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[Presentation] Anorectal transplantation research with rats, dogs, and human cadavers.
Author(s)
Araki, J., Nishizawa, Y., Sato, T., Naito, M., Akita, K., Tashiro, K., Iida, T., Koshima, I.
Organizer
World Society of Reconstructive Microsurgery 2013 Congress
Place of Presentation
Chicago (USA)
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[Book] 末梢神経の再生医療2013
Author(s)
中村達雄, 萩原明於, 稲田有史, 金丸眞一
Total Pages
192
Publisher
株式会社朝倉書店
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