Endometriosis-associated ovarian carcinogenesis induced by iron-dependent oxidative stress
| Project/Area Number |
23390391
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
吉田 昭三 奈良県立医科大学, 医学部, 助教 (40347555)
春田 祥司 (春田 祥治) 奈良県立医科大学, 医学部, 助教 (30448766)
重富 洋志 奈良県立医科大学, 医学部, 助教 (20433336)
吉澤 順子 奈良県立医科大学, 医学部, 助教 (80526723)
野口 武俊 奈良県立医科大学, 医学部, 助教 (10464661)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
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| Keywords | 子宮内膜症 / 癌化 / 卵巣癌 / 酸化ストレス / 鉄 / 卵巣がん / 細胞周期調節 |
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| Research Abstract |
The aim of the present study is to describe genomic instability, genetic polymorphisms and their haplotype, epigenetic alterations associated with endometriosis predisposition, and the key factors that have been linked to endometriosis-related ovarian neoplasms. Retrograde menstruation leads to iron overload, which facilitates the accumulation of somatic mutations through a Fenton reaction-mediated oxidative stress. There seems to be at least three spatiotemporally distinct phases of endometriosis development: The initial phase of genetic background inherited from parents would be followed by the second big wave of epigenetic modifications in the female offspring and the final phase of the iron overload that is subject to dynamic modulation later in life. The dramatic regulation of endometriosis susceptibility genes may come from a mechanism responsible for epigenetic and genetic mutations based on the microenvironmental changes.
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Report
(4 results)
Research Products
(73 results)
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[Journal Article] Modulation of estrogenic action in clear cell carcinoma of the ovary2012
Author(s)
Tanase Y, Yamada Y, Shigetomi H, Kajihara H, Oonogi A, Yoshizawa Y, Furukawa N, Haruta S, Yoshida S, Sado T, Oi H, Kobayashi H.
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Journal Title
Exp Ther Med.
Volume: 3
Pages: 18-24
Related Report
Peer Reviewed
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[Journal Article] New insights into pattern recognition receptors and their ligands in gynecologic pathologies2011
Author(s)
Yamada Y, Shigetomi H, Onogi A, Haruta S, Kawaguchi R, Yoshida S, Furukawa N, Nagai A, Tanase Y, Tsunemi T, Oi H, Kobayashi H
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Journal Title
Hum Immunol
Volume: 72
Pages: 213-218
Related Report
Peer Reviewed
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[Journal Article] The role of components of the chromatin modification machinery in carcinogenesis of clear cell carcinoma of the ovary2011
Author(s)
Shigetomi H, Oonogi A, Tsunemi T, Tanase Y, Yamada Y, Kajihara H, Yoshizawa Y, Furukawa N, Haruta S, Yoshida S, Sado T, Oi H, Kobayashi H
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Journal Title
Oncology Letters
Volume: 2
Pages: 591-597
Related Report
Peer Reviewed
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[Journal Article] Risk of carcinoma in women with ovarian endometrioma2011
Author(s)
Kobayashi H, Kajihara H, Yamada Y, Tanase Y, Kanayama S, Furukawa N, Noguchi T, Haruta S, Yoshida S, Naruse K, Sado T, Oi H
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Journal Title
Front Biosci
Volume: 3
Pages: 529-539
Related Report
Peer Reviewed
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[Journal Article] Redox-Active Iron-Induced Oxidative Stress in the Pathogenesis of Clear Cell Carcinoma of the Ovary2011
Author(s)
Yamada Y, Shigetomi H, Onogi A, Haruta S, Kawaguchi R, Yoshida S, Furukawa N, Nagai A, Tanase Y, Tsunemi T, Oi H, Kobayashi H
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Journal Title
Int J Gynecol Cancer
Volume: 21
Pages: 1200-1207
Related Report
Peer Reviewed
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[Presentation] 明細胞腺癌における転写因子HNF-1betaが制御するDNA損傷チェックポイント機構の解明2013
Author(s)
植栗千陽, 重富洋志, 小池奈月, 常見泰平, 成瀬勝彦, 金山清二, 川口龍二, 吉田昭三, 古川直人, 大井豪一, 小林 浩, 須藤 保
Organizer
第18回生殖医学フォーラム
Place of Presentation
長野
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[Presentation] 子宮内膜症におけるCD44v9の免疫組織学的検討2013
Author(s)
植栗千陽, 重富洋志, 重光愛子, 棚瀬康仁, 春田祥治, 金山清二, 川口龍二, 吉田昭三, 古川直人, 大井豪一, 小林 浩, 島田啓司, 小西 登, 須藤 保
Organizer
第12回日本婦人科がん分子標的研究会学術集会
Place of Presentation
奈良
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[Presentation] 卵巣漿液性腺癌におけるp16免疫染色の有用性に関する検討2013
Author(s)
金山清二, 大野澄美玲, 佐々木義和, 重光愛子, 棚瀬康仁, 春田祥治, 川口龍二, 吉田昭三, 古川直人, 大井豪一, 小林 浩
Organizer
第54回日本婦人科腫瘍学会学術集会
Place of Presentation
東京
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[Presentation] Evaluation of FRCA1 Gene Expression as a Prognostic Marker Peritoneal Cancer.2012
Author(s)
Furukawa N, Nagai A, Kasai T, Ohno S, Shigemitsu Y, Tanase Y, Haruta S, Kawaguchi R, Yoshida S, Oi H, Kobayashi H.
Organizer
14th Biennial Meeting of the International Gynecologic Cancer Society(IGCS)
Place of Presentation
Canada
Related Report
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