| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2011: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
|
|---|
| Research Abstract |
Activation of Toll-like receptors (TLRs) is thought to exacerbate inflammatory bone resorption. In the present study, we found that Poly(I:C), a synthetic double-stranded RNA (dsRNA) that acts as a ligand of Toll-like receptor 3 (TLR3), suppresses bone loss in osteoporosis model mice, while it inhibited osteoclastogenesis via production of interferon (IFN)-beta and the STAT1- dependent signaling pathway in osteoclast precursors. Thus, Poly(I:C) and TLR3 may be important components of a new therapeutic strategy for inflammatory bone loss.
|
