Roles played by histamine in strenuous or prolonged masseter muscle activity.
| Project/Area Number |
23390439
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Tohoku University |
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Principal Investigator |
WATANABE Makoto 東北大学, 歯学研究科(研究院), 客員教授 (80091768)
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| Co-Investigator(Kenkyū-buntansha) |
ENDO Yasuo 東北大学, 大学院歯学研究科, 教育支援者 (50005039)
YAMAGUCHI Satoshi 東北大学, 大学院歯学研究科, 助教 (50400263)
TSUCHIYA Masahiro 東北大学, 大学院歯学研究科, 大学院非常勤講師 (60372322)
三好 慶忠 東北大学, 歯学研究科(研究院), 非常勤講師 (10508948)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Keywords | 顎関節症 / ブラキシズム / ヒスタミン / 筋疲労 / 咬筋 / 疲労 / 咀嚼機能 / 慢性筋痛 |
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| Outline of Final Research Achievements |
Bruxism and/or clenching, resulting in fatigue or dysfunction of masseter muscles (MM), may cause temporomandibular disorders (TMD). Functional support of the microcirculation is critical for prolonged muscle activity. Histamine is a regulator of the microcirculation and is supplied by release from its stores and/or by de novo production via the induction of histidine decarboxylase (HDC). In the present study, we examined the roles of histamine and HDC in MM activity. Experiments were conducted using our R+G+ model. In addition that fexofenadine (a histamine H1 receptor antagonist) reduced MM activity, both H1 receptor-deficient and HDC-deficient mice exhibited low MM activity. Prolonged R+G+ induced HDC activity in MM. These results suggest that: (i) peripheral histamine supports strenuous MM activity; (ii) strenuous MM activity stimulates mast cells to release histamine and to induce HDC; and (iii) peripheral histamine H1 receptor antagonists may be effective in treating TMD.
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Report
(5 results)
Research Products
(29 results)
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[Journal Article] Chondrogenic and fibrotic process in the ligamentum flavum of patients with lumbar spinal canal stenosis.2015
Author(s)
Yabe Y, Hagiwara Y, Ando A, Tsuchiya M, Minowa T, Takemura T, Honda M, Hatori K, Sonofuchi K, Kanazawa K, Koide M, Sekiguchi T, Itoi E.
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Journal Title
Spine
Volume: 40
Issue: 7
Pages: 429-435
DOI
Related Report
Peer Reviewed
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[Journal Article] Long-term feeding on powdered food causes hyperglycemia and signs of systemic illness in mice.2014
Author(s)
Tsuchiya M, Niijima-Yaoita F, Yoneda H, Chiba K, Tsuchiya S, Hagiwara Y, Sasaki K, Sugawara S, Endo Y, Tan-No K, Watanabe M.
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Journal Title
Life Sci.
Volume: 103
Issue: 1
Pages: 8-14
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] NKG2D+ IFN-γ+ CD8+ T cells are responsible for palladium allergy.2014
Author(s)
Kawano M, Nakayama M, Aoshima Y, Nakamura K, Ono M, Nishiya T, Nakamura S, Takeda Y, Dobashi A, Takahashi A, Endo M, Ito A, Ueda K, Sato N, Higuchi S, Kondo T, Hashimoto S, Watanabe M, Watanabe M, Takahashi T, Sasaki K, Nakamura M, Sasazuki T, Narushima T, Suzuki R, Ogasawara K.
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Journal Title
PLoS One.
Volume: 9
Issue: 2
Pages: 1-12
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Roles played by histamine in strenuous or prolonged masseter muscle activity in mice.2013
Author(s)
Yoneda H, Niijima-Yaoita F, Tsuchiya M, Kumamoto H, Watanabe M, Ohtsu H, Yanai K, Tadano T, Sasaki K, Sugawara S, Endo Y.
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Journal Title
Clin Exp Pharmacol Physiol.
Volume: 40
Issue: 12
Pages: 848-855
DOI
Related Report
Peer Reviewed
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