|Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
|Outline of Final Research Achievements
The objective of this study was to evaluate the feasibility of fabricating artificial bone substitute from xenograft based on the compositional transformation to α-tricalcium phosphate followed by compositional transformation to carbonate apatite maintaining its macroscopic structure. Heat treatment at 900°C result in complete burning out of the organic substrate indicating antigen-antibody reaction will be completely eliminated. Then, the bone is further heated at 1500°C for compositional transformation to α-tricalcium phosphate which has higher reactivity and slightly dissolves in water. Then the bone with α-tricalcium phosphate composition was hydrothermally treated in 4 mol/L ammonium carbonate at 250°C. Based on the dissolution-precipitation reaction, composition of the bone with α-tricalcium phosphate composition transferred to carbonate apatite maintaining its macroscopic structure.