A study of bioactive materials used for filling bone defects
Project/Area Number |
23390450
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Dental engineering/Regenerative dentistry
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Research Institution | Tohoku University |
Principal Investigator |
SUZUKI Osamu 東北大学, 歯学研究科(研究院), 教授 (60374948)
|
Co-Investigator(Kenkyū-buntansha) |
ITOI Eiji 東北大学, 大学院・医学系研究科, 教授 (80193465)
KAMAKURA Shinji 東北大学, 大学院・医工学研究科, 教授 (80224640)
ANADA Takahisa 東北大学, 大学院・歯学研究科, 准教授 (30398466)
|
Project Period (FY) |
2011-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2013: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
|
Keywords | 生体材料学 / リン酸カルシウム / 天然高分子 / リン酸オクタカルシウム(OCP) / ゼラチン / 骨芽細胞 / 破骨細胞 / 骨再生 / リン酸オクタカルシウム(OCP) |
Research Abstract |
The present study was designed to investigate the effect of calcium phosphate crystal characteristics on the bioactivity of the bone substitute materials. The spongy composite consists of synthetic octacalcium phosphate (OCP) and natural polymers, such as gelatin, was prepared. OCP crystals, ground mechanically from micrometer to nano-submicro meter scale in size, were dispersed in gelatin matrix and molded. The composite was soaked in simulated body fluid for one week or implanted in rat calvaria critical-sized defect for 8 weeks and then analyzed. X-ray diffraction of the soaked materials showed that hydroxyapatite became detected with the time. Histological analysis of the decalcified specimens of the calvaria indicated that new bone was formed together with the partial biodegradation of the materials. The results suggest that the crystal characteristics may be a factor to affect the bioactivity of the composite.
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] STIMULATORY CAPACITY OF AN OCTACALCIUM PHOSPHATE/GELATIN COMPOSITE ON BONE REGENERATION IN A RABBIT TIBIA DEFECT MODEL2012
Author(s)
Suzuki K, Honda Y, Anada T, Handa T, Miyatake N, Takahashi A, Hosaka M, Imaizumi H, Itoi E, Suzuki O
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Journal Title
Phosphorus Research Bulletin
Volume: 26
Issue: 0
Pages: 53-58
DOI
NAID
ISSN
0918-4783, 1882-2363
Related Report
Peer Reviewed
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[Presentation] The architecture of regenerated bone by octacalcium phosphate and collagen composites (OCP/Col) in an alveolar bone defect model2012
Author(s)
Matsui A, Matsui K, Handa T, Tanuma Y, Miura K, Kato Y, Kawai K, Suzuki O, Kamakura S, Echigo S
Place of Presentation
Chengdu, China
Related Report
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[Presentation] The architecture of regenerated bone by octacalcium phosphate and collagen composites (OCP/Col) in an alveolar bone defect model.2012
Author(s)
Matsui A, Matsui K, Handa T, Tanuma Y, Miura K, Kato Y, Kawai K, Suzuki O, Kamakura S,Echigo S.
Organizer
9th World Biomaterials Congress (WBC)
Place of Presentation
Chengdu, China
Related Report
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