| Project/Area Number |
23406017
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Laboratory medicine
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| Research Institution | Osaka University |
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Principal Investigator |
Ikuta Kazuyoshi 大阪大学, 医学(系)研究科(研究院), 招へい教授 (60127181)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Yohei 京都府立医科大学, 医学研究科, 講師 (50452462)
NAKAYA Takaaki 京都府立医科大学, 医学研究科, 教授 (80271633)
SUZUKI Yasuo 中部大学, 生命健康科学部, 教授 (00046278)
TAKAHASHI Kazuo 大阪府立公衆衛生研究所, 感染症部, 部長 (10171472)
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| Co-Investigator(Renkei-kenkyūsha) |
DAIDOJI Tomo 京都府立医科大学, 医学研究科, 講師 (80432433)
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| Research Collaborator |
Ibrahim Madiha S. ダマンフール大学, 獣医学部, 教授
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Keywords | ウイルス学 / インフルエンザ / 人獣共通感染症 / 検査 / 国際研究者交流 / エジプト / 病態検査学 / 疫学 / 感染症 / ウイルス / 高病原性鳥インフルエンザ / 変異 / 鳥インフルエンザウイルス / タイ / アレキサンドリア大学 / ダマンフール大学 / マヒドン大学 / ヒト病原性 / 迅速診断キット / 病原性 / 遺伝子配列 |
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| Outline of Final Research Achievements |
H5N1 highly pathogenic avian influenza viruses have become endemic in birds in Southeast Aria and Egypt. In particular, Egypt has a substantially higher prevalence of H5N1 viruses than any other country, with collateral human infection. In this study, we developed a novel immunochromatographic strip test to detect influenza virus receptor binding specificity. Using the easy-to-use detection system, we surveyed the H5N1 virus dissemination and evolutionary dynamics in the H5N1 endemic areas. The results showed that a novel H5N1 virus variant with enhanced infectivity toward humans had emerged in Egypt and is now dominant in the country.
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