The epidemiological study on dioxin exposure, steroid hormone and prostatic cancer in Vietnam

• Project/Area Number: 23406018
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Hygiene
• Research Institution: Kanazawa University
• Principal Investigator: KIDO Teruhiko 金沢大学, 保健学系, 教授 (20167373)
• Co-Investigator(Kenkyū-buntansha): NAKAGAWA Hideaki 金沢医科大学, 医学部, 教授 (00097437)
• Co-Investigator(Renkei-kenkyūsha): KOU Eitetsu 金沢大学, 医学系, 准教授 (90283134) ; OKAMOTO Rie (NAGANUMA Rie) 金沢大学, 保健学系, 准教授 (50303285) ; MARUZENI Syouko 金沢大学, 保健学系, 研究員 (50599404)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2012: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000); Fiscal Year 2011: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
• Keywords: ダイオキシン類 / ステロイドホルモン / 前立腺がん / 枯葉剤 / ベトナム / 国際環境保健 / 衛生 / 環境 / ダイオキシン / 前立腺特異抗原 / 環境保健 / 性ホルモン

Research Abstract

To make clear the relation of dioxin exposure and steroid hormone and prostatic specific antigen (PSA), blood are collected from men at herbicide-sprayed and non-sprayed areas in Vietnam in 2010 and 2011.
As results, total dioxin levels were significantly higher in herbicide-sprayed area. PSA was not different between two areas. On steroid hormone, testosterone and estradiol were significantly higher, while dehydroepiandrosterone was significantly lower in herbicide-sprayed area. Multiple regression analysis was performed after adjusting four factors such as age, BMI, present occupation and smoking. As results, no significant association was found between dioxins and each steroid hormone.

Research Products

• [Journal Article] Serum dioxin levels in Vietnamese men more than 40 years after herbicide spraying (2014)
  • Author(s): Manh HD, Kido T, Okamoto R, Sun XL, Anh le T, Supratman S, Maruzeni S, Nishijo M, Nakagawa H, Honma S, Nakano T, Takasuga T, Nhu DD, Hung NN, Son le K
  • Journal Title: Environmental Science & Technology Volume: 48(6) Issue: 6 Pages: 3496-3503
  • DOI: 10.1021/es404853h
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between dioxin and steroid hormones in sera of Vietnamese men (2014)
  • Author(s): Sun XL, Kido T, Okamoto R, Manh HD, Maruzeni S, Nishijo M, Nakagawa H, Honma S, Nakano T, Takasuga T, Nhu DD, Hung NN, Son LK
  • Journal Title: Biomarkers Volume: 19(3) Issue: 3 Pages: 236-240
  • DOI: 10.3109/1354750x.2014.899626
  • Peer Reviewed / Open Access
• [Journal Article] The relationship between Agent Orange and prostate specific antigen: a comparison of a hotspot and a non-sprayed area in Vietnam. (2013)
  • Author(s): Xianliang Sun
  • Journal Title: Environmental Health and Preventive Medicine Volume: In press Issue: 5 Pages: 356-360
  • DOI: 10.1007/s12199-013-0330-1
  • Peer Reviewed
• [Presentation] Current elevated dioxin level in serum of Vietnamese old men : Past exposure or current exposure (2013)
  • Author(s): Manh HD, Kido T, Okamoto R, Sun XL, Maruzeni S, Nishijo M, Nakagawa H, Honma S, Nakano T, Takasuga T, Nhu DD, Hung NN, Son LK
  • Organizer: 33rd International Symposium on Halogenated Persistent Organic Pollutants
  • Place of Presentation: DAEGU大邱(大韓民国)
  • Year and Date: 2013-08-29
• [Presentation] The relationship between dioxin and steroid hormones in serum of Vietnamese men (2013)
  • Author(s): Sun XL, Kido T, Okamoto R, Manh HD, Maruzeni S, Nishijo M, Nakagawa H, Honma S, Nakano T, Takasuga T, Nhu DD, Hung NN, Son LK
  • Organizer: 33rd Inter-national Symposium on Halogenated Persistent Organic Pollutants
  • Place of Presentation: DAEGU大邱(大韓民国)
  • Year and Date: 2013-08-29
• [Presentation] The comparison of serum steroid hormone in men between a dioxin-hotspot and non-spraved area in Vietnam (2012)
  • Author(s): 孫献亮
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都大学(京都府)
  • Year and Date: 2012-03-25
• [Presentation] Current elevated dioxin level in serum of Vietnamese old men： Past exposure or current exposure
  • Author(s): Manh HD, Kido T, Okamoto R, XianLiang S, Maruzeni S, Nishijo M, Nakagawa H, Honma S, Nakano T, Takasuga T, Nhu DD, Hung NN, Son LK
  • Organizer: DIOXIN 2013
  • Place of Presentation: Hotel Inter-Burgo DAEGU 大邱（大韓民国）
• [Presentation] The relationship between dioxin and steroid hormones in serum of Vietnamese men
  • Author(s): Sun XL, Kido T, Okamoto R, Manh HD, Maruzeni S, Nishijo M, Nakagawa H, Honma S, Nakano T, Takasuga T, Nhu DD, Hung NN, Son LK
  • Organizer: DIOXIN 2013
  • Place of Presentation: Hotel Inter-Burgo DAEGU 大邱（大韓民国）
• [Presentation] Dioxin concentration in serum of Vietnamese men
  • Author(s): Ho Dung Manh
  • Organizer: 日本衛生学会
  • Place of Presentation: 金沢大学・金沢美術工芸大学（石川県）
• [Presentation] The relationship between dioxin and steroid hormones in serum of Vietnamese men
  • Author(s): Xianliang Sun
  • Organizer: 日本衛生学会
  • Place of Presentation: 金沢大学・金沢美術工芸大学（石川県）
• [Remarks]
  • URL: http://square.umin.ac.jp/k-chiiki/kido/index.html
• [Remarks]
  • URL: http://square.umin.ac.jp/k-chiiki/