Cognitive science on individual difference of impulsive behavior

• Project/Area Number: 23500329
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cognitive science
• Research Institution: Kyoto University
• Principal Investigator: NOMURA Michio 京都大学, 教育学研究科(研究院), 准教授 (60399011)
• Co-Investigator(Renkei-kenkyūsha): NOMURA Yasuyuki 横浜薬科大学, 薬学部, 教授 (00034041)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 衝動性 / 運動反応制御 / セロトニン / 遺伝子 / 個人差 / 前頭前野 / 自己制御 / 反応競合 / 遺伝子多型 / tDCS / 報酬・罰 / セロトニン神経系 / 運動反応 / 報酬 / 罰 / ドパミン

Research Abstract

Present study focuses on these interrelated areas through the lens of the serotonin transporter (5-HTT), looking specifically at the impulsivity in Japanese people. A large number of behavioral genetics studies have demonstrated that individuals carrying the less efficient S allele of the 5-HTTLPR gene have an increased susceptibility to emotion disorders, whereas this risk is much lower in collectivistic societies. A new hypothesis of gene-environment interaction proposed here addresses this mechanism by showing the following: (1) the behavioral regulation of S allele carriers impulsivity is optimized under aversive conditions, which may help them to adapt to collectivistic cultures; and (2) such self-regulatory responses underlied by the prefrontal cortex are modulated by cultural interdependent self-construal and psychosocial factors, such as general trust, all of which are geared toward modulating fear and social pain, and thus may lower the risk for impulsive behavior.

Research Products

• [Journal Article] Beautiful Faces Enhance Verbal Working Memory Performance: An NIRS Study. (2014)
  • Author(s): Kajimura, S., Himichi, T., & Nomura, M.
  • Journal Title: Psychologia: An International Journal of Psychological Sciences. Volume: .
  • NAID: 130003391457
  • Peer Reviewed
• [Journal Article] Non-conscious neural regulation against mortality concerns. (2013)
  • Author(s): Yanagisawa, K., Kashima. E. S., Moriya. H., Masui, K., Furutani, K., Nomura. M., Yoshida, H., & Ura, M.
  • Journal Title: Neuroscience Letters Volume: 552 Pages: 35-39
  • DOI: 10.1016/j.neulet.2013.07.027
  • Peer Reviewed
• [Journal Article] COMT Val 158 Met influences the perception of other's pain (2012)
  • Author(s): Himichi, T., Kaneko, M., Nomura, J., Okuma, Y., Nomura, Y., Nomura, M
  • Journal Title: Psychology Research Volume: 2 Pages: 185-195
  • Peer Reviewed
• [Journal Article] COMT Val 158 Met influences the perception of other's pain. (2012)
  • Author(s): Himichi, T., Kaneko, M., Nomura, J., Okuma, Y., Nomura, Y., Nomura, M.
  • Journal Title: Psychology Research Volume: 2 Pages: 185-195
  • Peer Reviewed
• [Journal Article] The interplay of genetic and environmental influences on prefrontal function and self-regulation of impulsivity (2011)
  • Author(s): Nomura, M
  • Journal Title: Psychologia : An International Journal of Psychological Sciences Volume: 54 Pages: 241-251
  • NAID: 130001896344
  • Peer Reviewed
• [Journal Article] Amount of altruistic punishment accounts for subsequent emotional gratification in participants with primary psychopathy (2011)
  • Author(s): Masui, K., Iriguchi, S., Nomura, M., Ura, M
  • Journal Title: Personality and Individual Differences Volume: 51 Pages: 823-828
  • Peer Reviewed
• [Journal Article] The effects of the behavioral inhibition and activation systems on social inclusion and exclusion (2011)
  • Author(s): Yanagisawa, K., Masui, K., Onoda, K., Furutani, K., Nomura, M., Ura, M., Yoshida, H
  • Journal Title: Journal of Experimental Social Psychology Volume: 47 Pages: 502-505
  • Peer Reviewed
• [Journal Article] The effects of reward and punishment on response inhibition in non-clinical psychopathy (2011)
  • Author(s): Masui, K., Nomura, M
  • Journal Title: Personality and Individual Differences Volume: 50 Pages: 69-73
  • NAID: 120002753740
  • Peer Reviewed
• [Journal Article] Does higher general trust serve as a psychosocial buffer against social pain? : A NIRS study of social exclusion (2011)
  • Author(s): Yanagisawa, K., Masui, K., Furutani, K., Nomura, M., Ura, M., Yoshida, H
  • Journal Title: Social Neuroscience Volume: 6 Pages: 377-387
  • Peer Reviewed
• [Journal Article] The interplay of genetic and environmental influences on prefrontal function and self-regulation of impulsivity (2011)
  • Author(s): Nomura, M.
  • Journal Title: Psychologia: An International Journal of Psychological Sciences Volume: 54 Pages: 241-151
  • NAID: 130001896344
  • Peer Reviewed
• [Journal Article] Perspective taking associated with social relationships : A NIRS study (2010)
  • Author(s): Nomura, Y., Ogawa, T., Nomura, M
  • Journal Title: Neuroreport Volume: 21 Pages: 1100-1105
  • Peer Reviewed
• [Journal Article] 衝動性の基盤となる構成概念, 脳, 遺伝子多型について-Stop Signal Paradaigm の観点より- (2010)
  • Author(s): 増井啓太・野村理朗
  • Journal Title: 感情心理学研究 Volume: 18 Pages: 15-24
• [Journal Article] Beautiful Faces Enhance Verbal Working Memory Performance : An NIRS Study
  • Author(s): Kajimura, S., Himichi, T., & Nomura, M
  • Journal Title: Psychologia : An International Journal of Psychological Sciences Volume: (in press)
  • NAID: 130003391457
  • Peer Reviewed
• [Presentation] Envy decreases attention to sadness. (2014)
  • Author(s): Fujita, H., Himichi, T., & Nomura, M.
  • Organizer: The 15th Annual Meeting of Society for Personality and Social Psychology.
  • Place of Presentation: San diego, USA
• [Presentation] Genes, brain and culture through a 5-HTT lens (2013)
  • Author(s): Nomura, M
  • Organizer: International Cultural Neuroscience Consortium Conference
  • Place of Presentation: Evanston, U.S
  • Year and Date: 2013-05-11
  • Invited
• [Presentation] Genes, brain and culture through a 5-HTT lens. (2013)
  • Author(s): Nomura, M.
  • Organizer: nternational Cultural Neuroscience Consortium Conference.
  • Place of Presentation: Evanston, U.SA
  • Invited
• [Presentation] 日常的な失敗傾向の背景要因に関する検討. (2013)
  • Author(s): 梶村昇吾・野村理朗.
  • Organizer: 日本心理学会第77回大会
  • Place of Presentation: 北海道医療大学
• [Presentation] 妬み情動が注意バイアスに及ぼす影響―空間手がかり課題及びfNIRSを用いた認知神経科学的検討―． (2013)
  • Author(s): 藤田弥世・日道俊之・野村理朗
  • Organizer: 日本心理学会第77回大会
  • Place of Presentation: 北海道医療大学
• [Presentation] 心的ストレスが他者の心的状態の推測へ及ぼす影響 ―fNIRSを用いた認知神経科学的検討―． (2013)
  • Author(s): 日道俊之・藤田弥世・野村理朗
  • Organizer: 日本心理学会第77回大会
  • Place of Presentation: 北海道医療大学
• [Presentation] Attractive faces enhance cognitive performance (2012)
  • Author(s): Kajimura, S., Himichi, T., Nomura, M
  • Organizer: 43rd NIPS International Symposium
  • Place of Presentation: Okazaki, Japan
• [Presentation] Involvement of a polymorphism in the 5-HTT gene in impulsive response style in Japanese population (2012)
  • Author(s): Nomura, M., Kaneko, M., Kusumi, I., Canli, T., Koyama, T., Nomura, Y
  • Organizer: 28th World Congress of Collegium Internationale Neuro-Psychopharmacologium (CINP)
  • Place of Presentation: Stockholm, Sweden
• [Presentation] Involvement of the 5-HT2A receptor gene polymorphism in trait anxiety, in activity of VLPFC and in impulsivity : a NIRS study (2012)
  • Author(s): Kajimura, S., Kaneko, M., Nomura, J., Okuma, Y., Nomura, Y., Nomura, M
  • Organizer: 28th World Congress of Collegium Internationale Neuro-Psychopharmacologium (CINP)
  • Place of Presentation: Stockholm, Sweden
• [Presentation] Biological and psychological basis of impulsive behavior. The 32nd Naito Conference (2011)
  • Author(s): Nomura, M
  • Organizer: Biological basis of mental functions and disorders
  • Place of Presentation: Yamanashi
  • Year and Date: 2011-10-21
  • Invited
• [Presentation] The interplay of genetic and environmental influences on prefrontal function and self-regulation of impulsivity (2011)
  • Author(s): Nomura, M
  • Organizer: International symposium "Towards an empirical understanding of cultural, social and evolutionary perspectives in psychological science"
  • Place of Presentation: Lancaster. U. K
  • Invited
• [Presentation] COMT Val158Met gene polymorphism influences the perception of others pain (2011)
  • Author(s): Himichi, T., Kaneko, M., Nomura, J., Okuma, Y., Nomura, Y., Nomura, M
  • Organizer: Clinical psychopharmacology and neuroscience, 2011, 9, P137. 2th Asian College of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
• [Presentation] COMT Val 158 Met polymorphism modulates impulsivity-related human behavior (2011)
  • Author(s): Nomura, M., Kondo, M. H., Kashino, M
  • Organizer: The International College of Neuropsychopharmacology, 1st IBRO MIDDLE EAST NEUROSCIENCE CONFERENCE
  • Place of Presentation: Al Ain, UAE
• [Presentation] COMT Val158Met gene polymorphism influences the perception of others pain. (2011)
  • Author(s): Himichi, T., Kaneko, M., Nomura, J., Okuma, Y., Nomura, Y., Nomura, M.
  • Organizer: 2th Asian College of Neuropsychopharmacology
  • Place of Presentation: Seoul
• [Presentation] The relationship between response disinhibition and rVLPFC deactivation in psychopathic participants : A near-infrared spectroscopy study (2010)
  • Author(s): Masui, K., Nomura, M
  • Organizer: 50th Annual Meeting of Society for Psychophysiological Research
  • Place of Presentation: Portland, USA
• [Presentation] Impulsivity-related human prefrontal brain activation during Go/No-go task is moderated by COMT Val 158 Met polymorphism : a fMRI study (2010)
  • Author(s): Nomura, M., Kondo, M. H., Kashino, M
  • Organizer: The International College of Neuropsychopharmacology
  • Place of Presentation: Honkong, China
• [Presentation] Involvement of a polymorphism in the 5-HTT gene in impulsive response style in Japanese population
  • Author(s): Nomura, M., Kaneko, M., Kusumi, I.,
  • Organizer: Internationale Neuro-Psychopharmacologium (CINP)
  • Place of Presentation: Stockholm
• [Presentation] Involvement of the 5-HT2A receptor gene polymorphism in trait anxiety, in activity of VLPFC and in impulsivity: a NIRS study
  • Author(s): Kajimura, S., Kaneko, M., Nomura, J., Canli, T., Koyama, T., Nomura, Y.
  • Organizer: Internationale Neuro-Psychopharmacologium (CINP)
  • Place of Presentation: Stockholm
• [Book] 青年期発達百科事典(第三巻「嗜癖」「ギャンブル」「アルコール摂取」「精神薬理学」「リスクテイキング行動」「喫煙」). 子安増生・二宮克美(監訳)丸善出版. (原書 : Brown, B. B. & Prinstein, M. J. (Ed.) (2014)
  • Author(s): 野村理朗(編集)
  • Publisher: Encyclopedia of Adolescence. Academic Press
• [Book] 脳とこころ 唐沢かおり(編)「新社会心理学 -心と社会をつなぐ知の統合-」 (2014)
  • Author(s): 野村理朗
  • Publisher: 北大路書房
• [Book] Genes, brain and culture through a 5-HTT lens. In Chiao, J, Shu-Chen, Rebecca, Bob (eds.), Handbook of Cultural Neuroscience: Cultural Neuroscience and Health. (2014)
  • Author(s): Nomura, M.
  • Publisher: Oxford University Press
• [Book] 青年期発達百科事典（第三巻「嗜癖」「ギャンブル」「アルコール摂取」「精神薬理学」「リスクテイキング行動」「喫煙」）．子安増生・二宮克美（監訳） (2014)
  • Author(s): 野村理朗
  • Publisher: 丸善出版
• [Book] 脳とこころ 唐沢かおり（編）「新社会心理学 -心と社会をつなぐ知の統合-」 (2014)
  • Author(s): 野村理朗
  • Total Pages: 15
  • Publisher: 北大路書房
• [Book] 情動 田中啓治・御子柴克彦（編）「脳科学辞典」 (2014)
  • Author(s): 野村理朗
  • Publisher: 脳科学辞典編集委員会
• [Book] Using NIRS to investigate social relationship in empathic process. "Infrared Spectroscopy - Life and Biomedical Sciences" (2012)
  • Author(s): Ogawa, T., Nomura, M
  • Publisher: InTech
• [Book] Psychopathy, Reward, and Punishment. (Eds.) Michela Balconi. "The Psychology of Reward" (2012)
  • Author(s): Masui, K., Nomura, M., Ura, M
  • Publisher: Nova Science Publishers
• [Book] Using NIRS to investigate social relationship in empathic process. (2012)
  • Author(s): Ogawa, T., Nomura, M
  • Total Pages: 12
  • Publisher: InTech
• [Book] Psychopathy, Reward, and Punishment. "The Psychology of Reward" (2012)
  • Author(s): Masui, K., Nomura, M., Ura, M.
  • Total Pages: 32
  • Publisher: Nova Science Publishers
• [Book] Nova Science Publishers (2012)
  • Author(s): Masui, K., Nomura, M., Ura, M.
  • Publisher: Psychopathy, Reward, and Punishment. "The Psychology of Reward"
• [Book] 衝動性 廣中直行(編)「「心理学研究法」 学習・動機・情動」 (2011)
  • Author(s): 野村理朗
  • Publisher: 誠心書房
• [Book] ニューロイメージング 子安増生・二宮克美(編)「キーワードコレクション・認知心理学」 (2011)
  • Author(s): 野村理朗
  • Publisher: 新曜社
• [Book] 衝動性 子安増生・二宮克美(編)「キーワードコレクション・認知心理学」 (2011)
  • Author(s): 野村理朗
  • Publisher: 新曜社
• [Book] 「心理学研究法」 学習・動機・情動 (2011)
  • Author(s): 野村理朗
  • Publisher: 誠心書房
• [Book] Genes, brain and culture through a 5-HTT lens. In Chiao, J, Shu-Chen, Rebecca, Bob (eds.), Handbook of Cultural Neuroscience : Cultural Neuroscience and Health
  • Author(s): Honkong, China
  • Publisher: New York : Oxford University Press(in press)
• [Remarks]
  • URL: http://www.researchgate.net/profile/Michio_Nomura