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Establishment and application of a general linear quadratic model that incorporates the time factor

Research Project

Project/Area Number 23500369
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Bioinformatics/Life informatics
Research InstitutionJikei University School of Medicine

Principal Investigator

Sekine Hiroshi  東京慈恵会医科大学, 医学部, 教授 (40187852)

Project Period (FY) 2011-04-28 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords放射線治療 / 分割照射 / 時間線量分割関係 / LQモデル / GLQモデル / 放射線感受性 / 放射線性紅斑 / 放射線皮膚炎 / 放射線反応性 / 不均一放射線感受性 / 乳房温存療法 / 放射線影響 / 皮膚紅斑 / ボロノイ図 / 直線2次モデル / 一般直線2次モデル / 乳房放射線照射 / シミュレーション
Outline of Final Research Achievements

Treatment effect of fractionated radiotherapy is defined by fractionated dose, fractionation interval, and the number of fractionation. Although traditional LQ model has variables of fractionated dose and the number of fractionation, it has not variable of fractionated interval. Therefore, this model can’t explain decline of local control after long time treatment split. Then, we developed GLQ model considering fractionated interval. This model explains following situations: It can compare the treatment effect of the various fractionation regimen. It proved that there is a possibility that the non-uniform radiosensitivity of the tumor participates in local recurrence after radiotherapy. It proved to be able to reproduce the radiation dermatitis which changes with time.
http://www.radbiolog.jp

Report

(6 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (22 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (15 results) Remarks (5 results)

  • [Journal Article] Temporal changes in skin erythema induced by fractionated radiotherapy simulated using the time-dependent linear-quadratic model2015

    • Author(s)
      Hiroshi Sekine, Kenji Suzuki
    • Journal Title

      Jikeikai Medical Journal

      Volume: 62 Pages: 1-7

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of simulation models of respiratory tracking and synchronizing for radiotherapy2014

    • Author(s)
      Hirosi Sekine, Yuki Otani
    • Journal Title

      The Mathematica Journal

      Volume: 16 Pages: 1-8

    • DOI

      10.3888/tmj.16-12

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] By the position of the treatment interruption: How to affect the local control rate2015

    • Author(s)
      Hiroshi Sekine, Hirokazu Saigusa, Kaoru Onoue, Koichirou Naruo, Koji Munskata, and Mayako Iwashita
    • Organizer
      北米放射線学会 RSNA
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-11-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Radiosensitivity heterogeneity of tumor affecting the local control rate by fractionated radiotherapy2015

    • Author(s)
      Hiroshi Sekine
    • Organizer
      日本放射線腫瘍学会 第28会学術大会
    • Place of Presentation
      前橋市
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 不均一な放射線感受性腫瘍に対する放射線治療の開始日が及ぼす局所制御率の比較2014

    • Author(s)
      関根 広
    • Organizer
      第27回日本放射線腫瘍学会学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-12-11 – 2014-12-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 不均一な放射線感受性腫瘍に対する放射線治療の休止期間による局所制御率の低下の検討2014

    • Author(s)
      関根 広
    • Organizer
      日本放射線影響学会第57回大会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-10-01 – 2014-10-03
    • Related Report
      2014 Research-status Report
  • [Presentation] 不均質な放射線感受性クローンをもつ腫瘍の線量・効果関係の解析2014

    • Author(s)
      関根 広
    • Organizer
      第52回日本放射線腫瘍学会生物部会
    • Place of Presentation
      京都
    • Year and Date
      2014-07-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 教育・説明用の呼吸同期および呼吸追尾照射のシミュレーションモデルの作成2014

    • Author(s)
      関根 広、大谷侑輝
    • Organizer
      日本高精度放射線外部照射研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 3D simulation of time-dose-fractionation relationship of non-homogeneous radiosensitive tumor2013

    • Author(s)
      H,Sekine, K.Owaki, C.Kanehira
    • Organizer
      ESTRO Intrnational Oncology Forum
    • Place of Presentation
      Geneva
    • Related Report
      2013 Research-status Report
  • [Presentation] Virtual computer simulation of skin erythema severity categorized by breast size using generalized LQ model2012

    • Author(s)
      H, Sekine, C. Kanehira, M,Aoki, M,Kobayashi, S. Takagi, K.Suzuki
    • Organizer
      第31回欧州放射線腫瘍学会(ESTRO)
    • Place of Presentation
      バルセロナ・スペイン
    • Related Report
      2012 Research-status Report
  • [Presentation] 乳房温存術後の放射線治療による皮膚紅斑. GLQモデルによる時間効果関係のシミュレーション2012

    • Author(s)
      関根 広、兼平千裕、青木学、小林雅夫、高木佐矢子
    • Organizer
      第50回日本放射線腫瘍学会学術大会生物部会
    • Place of Presentation
      沖縄県宜野湾市
    • Related Report
      2012 Research-status Report
  • [Presentation] 呼吸同期照射の動的シミュレーション2012

    • Author(s)
      関根 広、大脇和彦、青木 学、小林雅夫、高木佐矢子、兼平千裕
    • Organizer
      第25回日本高精度放射線外部照射研究会
    • Place of Presentation
      広島県広島市
    • Related Report
      2012 Research-status Report
  • [Presentation] Virtual computer simulation of skin erythema during and after breast conserving therapy using generalized LQ model2012

    • Author(s)
      H, Sekine, C. Kanehira, M,Aoki, M,Kobayashi, S. Takagi, K.Suzuki
    • Organizer
      第54回米国放射線腫瘍学会(ASTRO)
    • Place of Presentation
      ボストン・米国
    • Related Report
      2012 Research-status Report
  • [Presentation] 不均一な放射線感受性をもつ腫瘍の時間線量分割関係の3Dシミュレーション2012

    • Author(s)
      関根 広、大脇和彦、兼平千裕
    • Organizer
      第25回日本放射線腫瘍学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 線量分布にGLQ modelを適用し照射野内再発を解析的に考察する2011

    • Author(s)
      関根 広, 舟越和人, 熊崎 祐, 大谷侑輝
    • Organizer
      第439回日本医学放射線学会関東地方会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 乳房温存術後の放射線治療による皮膚紅斑の時間効果関係をコンピューターシミュレーションする2011

    • Author(s)
      関根 広, 兼平千裕, 佐伯俊昭
    • Organizer
      第19回日本乳癌学会学術総会
    • Place of Presentation
      仙台市
    • Related Report
      2011 Research-status Report
  • [Presentation] 分割照射による皮膚紅斑の時間効果関係をGLQモデルによる動的シミュレーションする2011

    • Author(s)
      関根 広, 兼平千裕, 青木 学, 小林雅夫, 高木佐矢子, 鈴木健之
    • Organizer
      第24回日本放射線腫瘍学会学術大会
    • Place of Presentation
      神戸市
    • Related Report
      2011 Research-status Report
  • [Remarks] 癌放射線治療の線量時間効果関係を表す時間組込一般直線2次モデルの確立と応用

    • URL

      http://www.radbiolog.jp/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 放射線治療の線量時間効果関係を表す時間組込一般直線2次モデルの確立と応用

    • URL

      http://www.radbiolog.jp/index.html

    • Related Report
      2014 Research-status Report
  • [Remarks] 癌放射線治療の線量時間効果関係を表す時間組込一般2次モデルの確立と応用

    • URL

      http://www.radbiolog.jp/

    • Related Report
      2013 Research-status Report
  • [Remarks] 癌放射線治療の線量時間効果関係を表す時間組込一般直線2次モデルの確立と応用

    • URL

      http://www.radbiolog.jp/

    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.radbiolog.jp/

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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