| Project/Area Number |
23500401
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neuroscience in general
|
|---|
| Research Institution | Toho University |
|---|
Principal Investigator |
SONE Masaki 東邦大学, 理学部, 准教授 (00397548)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAMURA Takuya 東京医科歯科大学, 難治疾患研究所, 助教 (80396647)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OKAZAWA Hitoshi 東京医科歯科大学, 難治疾患研究所, 教授 (50261996)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | ショウジョウバエ / 神経変性 / 神経変性疾患 / アルツハイマー病 / 認知症 / 細胞内タンパク質輸送 / 細胞内輸送 / トラフィッキング / モデル動物 / 脳・神経 |
|---|
| Research Abstract |
We studied mechanisms how impaired intracellular protein trafficking cause neurodegeneration or neurodegenerative diseases by means of Drosophila genetics. yata gene, which we identified, is required for the trafficking of Amyloid precursor protein that is a causative molecule of Alzheimer's disease. We performed genetic and molecular analyses of yata gene and some related genes, clarifed how imapaired intracellular protein trafficking cause abnormalities in cellular mechanisms and eventually neurodegeneration, and obtained clues to develop therapietic methods of neurodegenerative diseases.
|
