| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We have developed an exercise- and nutrition-based program to treat muscle atrophy. The week-long exercise program was effective at promoting recovery from muscle atrophy and increasing the number of sarcolemmal nuclei in each muscle fiber. These proliferated nuclei were outside the sarcolemma, suggesting an increase in the number of extrinsic cells. We also used skeletal muscle cultured cells to develop a model of muscle atrophy caused by muscle underutilization. In this model, the electrical stimulation of muscle cells (which causes contraction) is interrupted, simulating muscle underutilization and causing cellular atrophy. The aim of the model is to elucidate a mechanism for inhibiting muscle atrophy through exercise and nutrition. The findings from our model of muscle atrophy showed that both proteosynthesis and proteolysis increase in the early stage of interrupted muscular contraction, suggesting that amino acids released by proteolysis may result in increased proteosynthesis.
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