Prolonged effect of carnitine administration on metabolism and central nervous system of fasted carnitine-deficient mice
Project/Area Number |
23500783
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Sports science
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Research Institution | National Institute of Fitness and Sports in Kanoya |
Principal Investigator |
YOSHIDA GOICHIRO 鹿屋体育大学, スポーツ生命科学系, 准教授 (10274870)
|
Co-Investigator(Kenkyū-buntansha) |
SAHEKI Takeyori 鹿児島大学, 医歯学総合研究科, 研究員 (10056070)
YOSHITAKE Yutaka 鹿屋体育大学, スポーツ人文・応用社会科学系, 教授 (00136334)
|
Co-Investigator(Renkei-kenkyūsha) |
HORIUCHI Masahisa 鹿児島大学, 医歯学総合研究科, 教授 (50264403)
|
Project Period (FY) |
2011-04-28 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | カルニチン / 脂肪酸酸化 / JVSマウス / 絶食 / オレキシン / 中枢神経系 / 脂肪酸代謝 |
Outline of Final Research Achievements |
We examined the roles of carnitine in the general metabolism and the central nervous system, and the prolonged effects of carnitine administration to the fasted carnitine-deficient juvenile visceral steatosis (JVS) mice. Fasting reduced locomotor activity (LA) of JVS mice. Single carnitine administration caused an increase of the reduced LA and the fat expenditure, and the effects were prolonged for at least two days after the administration (as low as at the original carnitine-deficient state). In JVS mice, fasting also caused a decreased percentage of c-Fos positive orexin neurons in the lateral hypothalamus (ameliorated by carnitine administration). These results suggest that the reduced LA in fasted JVS mice is related to the inhibition of orexin neuronal activity.
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Report
(6 results)
Research Products
(16 results)
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[Journal Article] Carnitine deficiency induces a short QT syndrome2016
Author(s)
Roussel J, Labarthe F, Thireau J, Ferro F, Farah C, Roy J, Horiuchi M, Tardieu M, Lefort B, Francois Benoist J, Lacampagne A, Richard S, Fauconnier J, Babuty D, Le Guennec JY.
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Journal Title
Heart Rhythm
Volume: 13
Issue: 1
Pages: 165-174
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] CD56(dim)CD16(high) and CD56(bright)CD16(-) cell percentages associated with maximum knee extensor strength and incidence of death in elderly2016
Author(s)
Senpuku H, Miyazaki H, Yoshihara A, Yoneda S, Narisawa N, Kawarai T, Nakagawa N, Miyachi M, Tada A, Yoshida G, Shimada M, Ohashi M, Nishimuta M, Kimura Y, Yoshitake Y.
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Journal Title
Springerplus
Volume: 5
Issue: 1
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Screening for five prevalent mutations of SLC25A13 gene in Guangdong, China: a molecular epidemiologic survey of citrin deficiency2014
Author(s)
Zhang ZH, Yang ZG, Chen FP, Kikuchi A, Liu ZH, Kuang LZ, Li WM, Song YZ, Kure S, Saheki T
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Journal Title
Tohoku J Exp Med
Volume: 233
Pages: 275-281
Related Report
Peer Reviewed / Open Access
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[Journal Article] Cytosolic reducing power preserves glutamate in retina2013
Author(s)
Du J, Cleghorn W, Contreras L, Linton JD, Chan GC, Chertov AO, Saheki T, Govindaraju V, Sadilek M, Satrustegui J, Hurley JB.
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Journal Title
Proc Natl Acad Sci USA
Volume: 110
Issue: 46
Pages: 18501-18506
DOI
Related Report
Peer Reviewed
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