Pathophysiology of non-obese subjects with impaired glucose tolerance

• Project/Area Number: 23500857
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Juntendo University
• Principal Investigator: SATO Fumihiko 順天堂大学, 医学部, 准教授 (10445538)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 耐糖能障害 / インスリン抵抗性 / インスリン分泌 / 異所性脂肪

Research Abstract

The mechanisms of hyperglycemia in non-obese IGT subjects are not fully understood. In this project, to clarify the pathophysiology in non-obese IGT, we performed glucose clamp and oral glucose tolerance test with double glucose tracer. Our preliminary result suggested that impaired hepatic glucose uptake and insulin resistance in muscle may contribute to hyperglycemia in IGT subjects. Further experiment will be required for confirming these results.

Research Products

• [Journal Article] Determinants of intramyocellular lipid accumulation after dietary fat loading in non-obese men (2011)
  • Author(s): Sakurai Y, Tamura Y, Takeno K, Kumashiro N, Sato F, Kakehi S, Ikeda S, Ogura Y, Saga N, Naito H, Katamoto S, Fujitani Y, Hirose T, Kawamori R,Watada H
  • Journal Title: Journal of Diabetes Investigation Volume: 2 Issue: 4 Pages: 310
  • DOI: 10.1111/j.2040-1124.2010.00091.x
  • Peer Reviewed
• [Journal Article] Association of T2 relaxation time determined by magnetic resonance imaging and intramyocellular lipid content of the soleus muscle in healthy subjects (2011)
  • Author(s): 櫻井裕子、田村好史、河盛隆造、綿田裕孝
  • Journal Title: J Diabetes Invest Volume: 2 Issue: 5 Pages: 356-358
  • DOI: 10.1111/j.2040-1124.2011.00108.x
  • Peer Reviewed
• [Presentation] Gene expression difference of skeletal musclle between intramyocellar accumelated insulin sensitive and insulin resistant individuarls. (2011)
  • Author(s): Kawaguchi M, Tamura Y, Takeno K, Sakurai Y, Sato F, Kakehi S, Ikeda S, Kim M, Yamamoto R, Ogura Y, Saga N, Katamoto S, Kanazawa A, Fujitani Y, Hirose T, Kawamori R,Watada H
  • Organizer: American Diabetes Association 71st scientific sessions
  • Place of Presentation: San Diego (America)
• [Presentation] Gene Expression Profile in Skeletal Muscle Related to the intracellular Lipid Accumulation in Endurance Athletes. (2011)
  • Author(s): Takeno K, Tamura Y, Sakurai Y, Sakurai Y, Sato F, Kakehi S, Ikeda S, Kim M, Yamamoto R, Ogura Y, Saga N, Katamoto S, Fujitani Y, Hirose T, Kawamori R,Watada H
  • Organizer: American Diabetes Association 71st scientific sessions
  • Place of Presentation: San Diego (America)
• [Presentation] Changes in Intramyocellular Lipid Accumulation and Insulin Sensitivity after High-Fat Loading Are Associated with Transcriptional Response in Human Skeletal Muscle. (2011)
  • Author(s): Kakehi S, Tamura Y, Sakurai Y, Takeno K, Kawaguchi M, Sato F, Ikeda S, Kim M, Yamamoto R, Ogura Y, Saga N, Katamoto S, Fujitani Y, Hirose T, Kawamori R,Watada H
  • Organizer: American Diabetes Association 71st scientific sessions
  • Place of Presentation: San Diego (America)
• [Presentation] 肥満・非肥満2型糖尿病患者における、脂肪肝を有する患者の特徴. (2011)
  • Author(s): 稲垣賀子, 田村好史, 佐藤文彦, 平岡輝余子, 伊藤千春, 南方涼子, 山本理紗子, 波多江千恵, 藤谷与士夫, 弘世貴久, 綿田裕孝,河盛隆造
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 北海道、札幌市
• [Book] 糖尿病薬物療法 BRUSHUP, (2011)
  • Author(s): 佐藤文彦
  • Publisher: 日本医事新報社