A new strategy to conquer obesity by use of a newly discovered intranasal infusion of anorexigenic peptide and exercise
| Project/Area Number |
23500863
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Hoshi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIODA Seiji 昭和大学, 医学部, 教授 (80102375)
KAGEYAMA Haruaki 桐生大学, 医療保健学部, 准教授 (00433839)
SUZUKI Tsutomu 星薬科大学, 薬学部, 教授 (90130757)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 抗肥満ペプチド / 運動療法 / 点鼻投与 / マウス / エネルギー代謝 / 摂食調節 / ストレス / 視床下部 / ニューロペプチドW / ガラニン様ペプチド / 抗肥満作用 / GPCR / 神経ネットワーク / 機能形態学的解析 / 国際情報交流 |
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| Research Abstract |
Anorexigenic peptide, which regulates feeding and energy metabolism but there is no reports to use of this peptide and exercise for obese animals efficiently. In this study, we have established the intranasal infusion method of anorexigenic peptide for animals. We have studied obese animals and we got the data that intranasal infusion of anorexigenic peptide and voluntary exercise were effective on these animals to loose body weight and food intake. Suggested that intranasal infusion of anorexigenic peptid and voluntary exercise are useful for obese people to conquer obesity and life-style related diseases in future.
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Report
(4 results)
Research Products
(106 results)
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[Presentation]2014
Author(s)
Takenoya, F., Kageyama, H., Shioda, S, et al
Organizer
20th International Symposium on Regulatory Peptides
Place of Presentation
Kyoto, Japan
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[Presentation] Interactive effect of galanin-like peptide (GALP) and spontaneous exercise on energy metabolism2014
Author(s)
Takenoya, F, Ito, K., Kageyama, H, Hirako, T, Ota, E, Wada, N, Yamamoto N, Ryushi, T, Shioda,S
Organizer
18th Annual Congress of the ECSS
Place of Presentation
RAI, Amsterdam
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[Presentation] Takenoya, F, Ito, K, Kageyama, H, Hirako, T, Ota, E, Wada, N, Yamamoto N, Ryushi, T, Shioda,S2014
Author(s)
Takenoay F, Kageyama H, Hirako S, Wada N, Watanabe J, Ryushi T, Shioda S
Organizer
44st Annual meeting Society for Neuroscience
Place of Presentation
Washington, DC
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[Presentation] Neuropeptide W (NPW) modulated of food intake by stress response and voluntary exercise in mouse2013
Author(s)
Takenoya, , Kageyama, , Hirako, T, Ota, E, Yamamoto N, Ryushi, T, Shioda,S
Organizer
18th Annual Congress of the ECSS
Place of Presentation
Spain, Barcelona
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[Presentation] Takenoya, F., Kageyama, H., Hirako, T., Ota, E., Yamamoto N., Ryushi, T., Shioda,S.2013
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[Presentation] Neuropeptide W induced hypophagia is mediated via a CRH neurons2013
Author(s)
Takenoya, F., Kageyama, H., Hirako, T., Ota, E., Yamamoto, N., Ryushi, T., Shioda,S.
Organizer
Neuroscience 2013
Place of Presentation
San Diedo, California
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[Book] Chapter 136 - Neuropeptide B/W2013
Author(s)
Fumiko Takenoya, Haruaki Kageyama, Ki Sung Kang, Seiji Shioda
Total Pages
2032
Publisher
Handbook of Biologically Active Peptides (Second Edition)
Related Report
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[Book] Chapter 115 - Neuropeptide B/W2013
Author(s)
Fumiko Takenoya, Haruaki Kageyama, Ki Sung Kang, Seiji Shioda
Total Pages
2032
Publisher
Handbook of Biologically Active Peptides (Second Edition)
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