The role of lipoprotein receptor LR11 in diabetic complications
| Project/Area Number |
23500870
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
KABURAGI Yasushi 独立行政法人国立国際医療研究センター, その他部局等, 部長 (40342927)
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| Co-Investigator(Kenkyū-buntansha) |
KUBOTA Hiroyuki (UNOKI Hiroyuki) 独立行政法人国立国際医療研究センター, 研究所・糖尿病研究センター・臓器障害研究部, 室長 (40323290)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 糖尿病性血管障害 / 糖尿病腎症 |
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| Research Abstract |
We sought the association between soluble form of LR11 (sLR11) and development of nephropathy among patients with type 2 diabetes (T2DM). sLR11 was determined in the serum samples of 39 healthy normoglycemic control subjects, 38 T2DM patients, 34 T2DM patients with microalbuminuria, and 53 T2DM patients with macroalbuminuria. Circulating sLR11 was significantly increased in patients with diabetic nephropathy compared with healthy subjects. Multivariate regression analysis showed that circulating sLR11 is independent contributing factor for urinary albumin to creatinine ratio (beta:0.22), as well as duration of diabetes(beta:-0.22), systolic blood pressure (beta:0.17), HbA1c(beta:0.22) and eGFR(beta:-0.24). Logistic regression analysis indicated that sLR11 was independently associated with diabetic nephropathy, as well as HbA1c and Cre. There is a statistical significant association between LR11 and albuminuria and may be a useful biomarker for the development of diabetic nephropathy.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Leukocyte cell-derived chemotaxin 2 is a zinc-binding protein2013
Author(s)
Okumura A, Suzuki T, Miyatake H, Okabe T, Hashimoto Y, Miyakawa T, Zheng H, Unoki-Kubota H, Ohno H, Dohmae N, Kaburagi Y, Miyazaki Y, Tanokura M, Yamagoe S
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Journal Title
FEBS Lett
Volume: 587
Issue: 5
Pages: 404-409
DOI
Related Report
Peer Reviewed
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[Journal Article] Identification of tuberculosis-associated proteins in whole blood supernatant.2011
Author(s)
Tanaka T, Sakurada S, Kano K, Takahashi E, Yasuda K, Hirano H, Kaburagi Y, Kobayashi N, Le Hang NT, Lien LT, Matsushita I, Hijikata M, Uchida T, Keicho N
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Journal Title
BMC Infect Dis.
Volume: 11
Issue: 1
Pages: 71-71
DOI
Related Report
Peer Reviewed
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[Presentation] 糖尿病性細小血管症バイオマーカー探索の試み2012
Author(s)
鏑木 康志, 佐藤 恵美, 本間 綾香, 加納 圭子, 高橋 枝里, 奥村 彰規, 中村 直子, 佐伯 久美子, 湯尾 明, 平野 久, 久保田 浩之
Organizer
第55回日本糖尿病学会年次学術集会
Place of Presentation
横浜
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