Biological activities of water-soluble free oligosaccharides obtained from edible beans and their applications.
| Project/Area Number |
23500944
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Kobe Women's University (2013-2015)
Kurashiki Sakuyo University (2011-2012) |
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Principal Investigator |
KIMURA Mariko 神戸女子大学, 家政学部, 准教授 (00351932)
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| Research Collaborator |
NAGASAWA Haruko 神戸女子大学, 家政学部, 教授 (50164413)
MAEDA Megumi 岡山大学, 自然科学研究科, 助教 (20434988)
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| Project Period (FY) |
2011-04-28 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 雑豆 / オリゴ糖 / ペプチド / 機能性 / プレバイオティクス / 低利用資源 / 糖ペプチド / 高機能性 / 糖鎖 / 機能性食材 / 機能性食品 |
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| Outline of Final Research Achievements |
In this study, we analyzed functional and structural features of free oligo- saccharides prepared from Zatsu mame (defined as edible beans other than soybean and peanut in Japanese) to find out good sources of latent bioactive oligosaccharides.
At first, we prepared several kinds of glycopeptides and oligosaccharide fractions from Adzuki and Tebo by a combination of cation exchange chromatography and gel filtration. Using bean glycopeptides and γ-polyglutamic acid, we developed a novel glyco-polymer bearing several hundreds of oligosaccharides and assayed stimulating activity to antigen presentation cells, T-cell proliferation, and production of cytokines. Prebiotic activities of the bean-oligosaccharides on growth of bifidobacteria and lactobacilii were determined by measuring the number of these bacteria, suggesting that Adzuki and Tebo contain prebio-active oligosaccharides or glycopeptides.
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Report
(6 results)
Research Products
(16 results)
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[Journal Article] Synthesis and Biological Activity of Inositol Phospholipid as NKT Cell Modulator2015
Author(s)
Aiba, T., Suehara, S., Bernin, H., Lotter, H., Inuki, S., Fukase, K., Fujimoto, Y.
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Journal Title
Glycoconjugate J.
Volume: 32
Issue: 5
Pages: 301-301
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Large-Scale Preparation of Asn-Glycopeptide Carrying Structurally Homologous Antigenic <i>N</i>-Glycan2013
Author(s)
Maeda, M., Takeda, N., Mano, A., Yamanishi, M., Kimura, M., and Kimura, Y.
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Journal Title
Bioscience, Biotechnology, and Biochemistry
Volume: 77
Issue: 6
Pages: 1269-1274
DOI
NAID
ISSN
0916-8451, 1347-6947
Related Report
Peer Reviewed
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