| Project/Area Number |
23500973
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Fujita Health University |
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Principal Investigator |
INUO Chisato 藤田保健衛生大学, 医学部, 助教 (30586780)
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| Co-Investigator(Kenkyū-buntansha) |
URISU Atsuo 藤田保健衛生大学, 坂文種報徳會病院 小児科, 客員教授 (20193972)
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| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 低アレルゲン / 食物アレルギー / 免疫療法 / アレルギー / 食物 / 加工食品 |
|---|
| Research Abstract |
To cow's milk allergy patients, the usefulness of immunotherapy to induce remission by taking milk have been reported. However, skin symptoms, gastrointestinal symptoms, and respiratory symptoms are induced frequently by the milk oral immunotherapy. In this study, we investigated the safety and efficacy of oral immunotherapy using peptide milk. The peripheral blood basophils activations in the blood of the severe milk allergy patients against peptides milk were lower than that of normal milk. In the double-blind food challenge test, the severe milk allergy patients can eat the larger amount of peptide milk than that of normal milk. The oral immunotherapy using peptides milk increased the durable amount of milk without any symptoms for the milk allergy patients in patients of 80%.
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