| Project/Area Number |
23501297
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor diagnosis
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIRAO Kuniaki 大分大学, 医学部, 教授 (10467996)
HATANO Yutaka 大分大学, 医学部, 教授 (80336263)
OOTSU Satoshi 大分大学, 医学部, 助教 (80437920)
MORINAGA Ryotaro 大分大学, 医学部, 助教 (50411640)
HIIRASHIMA Yoshinori 大分大学, 医学部, 助教 (60418837)
HISAMATSU Yasushi 大分大学, 医学部, 助教 (00609670)
NISHIKAWA Kazuo 大分大学, 医学部, 医員 (70636399)
KAWANO Sakura 大分大学, 医学部, 医員 (40548137)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 獲得耐性 / 上皮成長因子受容体阻害薬 / 薬剤性皮膚障害 / ざ瘡様皮疹 / CTLA-4 / 制御性T細胞 / がん / 癌 / EGFR阻害薬 / FOXP3 / ＥＧＦＲ阻害薬 / 制御性Ｔ細胞 / ＣＴＬＡ-4 / ＦＯＸＰ3 |
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| Outline of Final Research Achievements |
Our clinical study "The effect of regulatory T cells on resistance mechanism following the treatment with epidermal growth factor receptor inhibitors" was registered on University hospital Medical Information Network in Oct 1st 2012. Infiltration of regulatory T cells expressing FOXP3 and CTLA-4 into epidermis was observed in immunohistochemistry analysis. The Levels of CTLA-4 mRNA was upregulated depending on time in epidermis and circulating lymphocytes. However, it is difficult to enable proper aberration correction of inflammatory and regulatory cytokines from epidermis and circulating lymphocytes in the limited samples. The careful observation during the extended period would be needed in the further numbers of samples.
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