Detection of residual radiation and internal exposure in the specimen of atomic bomb victims
| Project/Area Number |
23510064
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Nagasaki University |
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Principal Investigator |
SHICHIJO Kazuko 長崎大学, 原爆後障害医療研究所, 助教 (90136656)
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| Co-Investigator(Kenkyū-buntansha) |
NAKASHIMA Masahiro 長崎大学, 原爆後障害医療研究所, 教授 (50284683)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKATSUJI Toshihiro 長崎大学, 環境科学部, 教授 (70163219)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Keywords | 線量測定・評価 / 内部被曝 / 原爆被爆者 / 低線量放射線 / アルファ線 / プルトニウム / グリッドチェンバー検出器 / ゲノム不安定性 / グリッドチェンバー 検出器 |
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| Research Abstract |
In patients subjected to Atomic bomb there was no evidence of introduction of radioactive material. A much more palpable danger would exist from the ingestion or inhalation of radioactive material to increase cancer risks.
Here, we studied the preserved body cells of Nagasaki A-bombed victims in 1945, and became the first one to prove that plutonium (Pu) is continuing to emit radiations after more than 70 years in human body since the A-bomb attack.
Alpha particles emitted from the specimen such as lung, liver, bone etc. were detected by autoradiography. The frequency distribution of alpha-particle track lengths of A-bomb cases was consistent with the pattern of alpha-particles emitted from 239, 240Pu, different from that of controls. The internal radioactivity of A-bomb cases was higher than that of controls and relevant for factors of shielding and death time. Our achievement will pave the way to study 'internal A-bombed' and has contributed a lot to support the Hibakusya's insistence.
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Report
(4 results)
Research Products
(84 results)
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[Journal Article] Radiation-associated small cell neuroendocrine carcinoma of the thyroid: a case report with molecular analyses.2014
Author(s)
Mussazhanova Z, Miura S, Stanojevic B, Rogounovitch T, Shiraishi T, Kurashige T, Shichijo K, Kaneko K, Takahashi H, Ito M, Nakashima M
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Journal Title
Thyroid
Volume: 24
Issue: 3
Pages: 593-598
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Thyrotropin signaling confers more aggressive features with higher genomic instability on BRAFV600E-induced thyroid tumors in a mouse model.2014
Author(s)
Orim F, Bychkov A, Shimamura M, Nakashima M, Ito M, Matsuse M, Kurashige T, Suzuki K, Saenko V, Nagayama Y, Yamashita S, Mitsutake N
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Journal Title
Thyroid
Volume: 24(3)
Issue: 3
Pages: 502-510
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] A predictive factor of the quality of microarray comparative genomic hybridization analysis for formalin-fixed paraffin-embedded archival tissue.2013
Author(s)
Nakao K, Oikawa M, Arai J, Mussazhanova Z, Kondo H, Shichijo K, Nakashima M, Hayashi T, Yoshiura K, Hatachi T, Nagayasu T
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Journal Title
Diagnostic Molecular Pathology
Volume: 22
Issue: 3
Pages: 174-180
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] One-stage, simultaneous skin grafting with artificial dermis and basic fibroblast growth factor successfully improves elasticity with maturation of scar formation.2013
Author(s)
Hamuy R, Kinoshita N, Yoshimoto H, Hayashida K, Houbara S, Nakashima M, Suzuki K, Mitsutake N, Mussazhanova Z, Kashiyama K, Hirano A, Akita
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Journal Title
Wound Repair and Regeneration
Volume: 21(1)
Issue: 1
Pages: 141-154
DOI
Related Report
Peer Reviewed
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[Journal Article] Establishment of a New Murine Model of Liver Abscess Due to Fusobacterium necrophorum via Injection into Caudal Vein.2013
Author(s)
Nagaoka K, Yanagihara K, Harada Y, Yamada K, Migiyama Y, Morinaga Y, Izumikawa K, Kakeya H, Nakashima M, Nishimura M, Kohno S
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Journal Title
Journal of Medical Microbiology
Volume: 62(11)
Issue: 11
Pages: 1755-1759
DOI
Related Report
Peer Reviewed
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[Journal Article] Significance of p53-binding protein 1 (53BP1) expression in thyroid papillary microcarcinoma: association with BRAFV600E mutation status.2013
Author(s)
Mussazhanova Z, Matsuda K, Naruke Y, Mitsutake N, Stanojevic B, Rogounovitch T, Saenko V, Suzuki K, Nishihara E, Hirokawa M, Ito M, Nakashima M.
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Journal Title
HIstopathology
Volume: 63
Issue: 5
Pages: 726-734
DOI
Related Report
Peer Reviewed
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[Journal Article] Novel diagnostic procedure for determining metastasis to sentinel lymph nodes in breast cancer using a semi-dry dot-blot method.2013
Author(s)
Otsubo R, Oikawa M, Hirakawa H, Shibata K, Abe K, Hayashi T, Kinoshita N, Shigematsu K, Hatachi T, Yano H, Matsumoto M, Takagi K, Tsuchiya T, Tomoshige K, Nakashima M, Taniguchi H, Omagari T, Itoyanagi N, Nagayasu T
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Journal Title
International Journal of Cancer
Volume: 134(4)
Issue: 4
Pages: 905-912
DOI
Related Report
Peer Reviewed
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[Journal Article] Summary of pathologic projects on atomic bomb disease medicine research2012
Author(s)
Nakashima M, Miura S, Shichijo K,Matsuyama M, Kurashige T, Matsuda K,Mussazhanova Z, Kondo H, Suzuki K,Tsukasaki K, Yoshiura K, Naruke Y, Ito M, Sekine I
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Journal Title
A New Challenge of Radiation Health Risk Management, Nakashima M, Takamuea N, Suzuki K, Yamashita S. (Eds)
Volume: 0
Pages: 137-144
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[Presentation] Summary of pathologic projects on atomic bomb disease medicine research2011
Author(s)
Nakashima M, Miura S, Shichijo K,Matsuyama M, Kurashige T, Matsuda K,Mussazhanova Z, Kondo H, Suzuki K,Tsukasaki K, Yoshiura K, Naruke Y, Ito M, Sekine I
Organizer
The 6th International Symposium of Nagasaki University Global COE Program "Global Strategic Center for Radiation Health Risk Control"
Place of Presentation
Nagasaki
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