| Project/Area Number |
23510084
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
UENO Susumu 産業医科大学, 産業生態科学研究所, 教授 (00279324)
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| Co-Investigator(Kenkyū-buntansha) |
FUETA Yukiko 産業医科大学, 産業保健学部, 講師 (10132482)
YOSHIDA Yasuhiro 産業医科大学, 医学部, 准教授 (10309958)
ISHIDAO Toru 産業医科大学, 産業保健学部, 講師 (90212901)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 1-ブロモプロパン / 揮発性有機化合物 / 胎生期曝露 / 海馬神経回路 / 神経行動 / 飼育環境 / 臭素イオン / 発達神経毒性 / １-ブロモプロパン / ペンチレンテトラゾール / 有機溶剤 / オープンフィールド試験 / カイニン酸 / フロン代替物質 / 社会的行動 |
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| Research Abstract |
The purpose of this research project is to evaluate developmental neurotoxicity of volatile organic compounds, and to explore a biomarker which can be applied to an evaluation index for the toxicity. We used model rats which were prenatally exposed to an organic solvent 1-bromopropane (1BP), and as a result, we found that a breeding environment soon after weaning day could affect exploration activity, although it was observed transiently. Additionally, we found that prenatal 1BP-exposure could enhance the development of the stimulation-response relationship in brain neural circuit, which could partly due to an accumulation of bromine ion in brain.
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