| Project/Area Number |
23510085
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | National Institute for Minamata Disease |
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Principal Investigator |
SAKAMOTO Mineshi 国立水俣病総合研究センター, その他部局等, その他 (60344420)
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| Co-Investigator(Kenkyū-buntansha) |
KAMEO Satomi 群馬大学, 大学院医学系研究科, 助教 (40312558)
MARUMOTO Masumi 環境省 国立水俣病総合研究センター, 基礎研究部, 主任研究員 (00335506)
YASUTAKE Akira 熊本大学, 自然科学研究科, 研究員 (20344418)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO Megumi 環境省 国立水俣病総合研究センター, 基礎研究部, 室長 (70344421)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | メチル水銀 / セレン / 相互作用 / 歯クジラ / 住民 / 水俣病 / 水俣湾ヘドロ / セレノメチニオン / ラット / 発達期の脳 / クジラ / セレノメチオニン |
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| Research Abstract |
Selenium(Se) is an essential element and may play a role for the protection of MeHg toxicity. We have detected the protective effect of Se against neuronal degeneration induced by MeHg in the developing postnatal rat brain by using a postnatal model rat which is suitable to extrapolate the effects of MeHg in the fetus brain of human (Eco Tox Env Saf 2010). In tooth-whales, MeHg concentrations were positively associated with T-Hg concentrations. However, the MeHg concentrations appeared to reach a plateau. In all species of tooth-whales, Se/I-Hg molar ratio decreased with the increase in T-Hg concentrations, and eventually reached a constant ratio of 1 (Se:I-Hg=1:1). EPMA showed that Hg and Se in the bottlenose dolphin existed in the same place. Hg and Se in blood of inhabitants in a whaling town showed significant and positive correlations in both sexes. The increased Se in blood associated with the Hg level may play a role in protecting against MeHg toxicity in the inhabitants.
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