Selenomethionine protects against neuronal degeneration by methylmercury in the developing rat brain.
| Project/Area Number |
23510085
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | National Institute for Minamata Disease |
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Principal Investigator |
SAKAMOTO Mineshi 国立水俣病総合研究センター, その他部局等, その他 (60344420)
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| Co-Investigator(Kenkyū-buntansha) |
KAMEO Satomi 群馬大学, 大学院医学系研究科, 助教 (40312558)
MARUMOTO Masumi 環境省 国立水俣病総合研究センター, 基礎研究部, 主任研究員 (00335506)
YASUTAKE Akira 熊本大学, 自然科学研究科, 研究員 (20344418)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO Megumi 環境省 国立水俣病総合研究センター, 基礎研究部, 室長 (70344421)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | メチル水銀 / セレン / 相互作用 / 歯クジラ / 住民 / 水俣病 / 水俣湾ヘドロ / セレノメチニオン / ラット / 発達期の脳 / クジラ / セレノメチオニン |
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| Research Abstract |
Selenium(Se) is an essential element and may play a role for the protection of MeHg toxicity. We have detected the protective effect of Se against neuronal degeneration induced by MeHg in the developing postnatal rat brain by using a postnatal model rat which is suitable to extrapolate the effects of MeHg in the fetus brain of human (Eco Tox Env Saf 2010). In tooth-whales, MeHg concentrations were positively associated with T-Hg concentrations. However, the MeHg concentrations appeared to reach a plateau. In all species of tooth-whales, Se/I-Hg molar ratio decreased with the increase in T-Hg concentrations, and eventually reached a constant ratio of 1 (Se:I-Hg=1:1). EPMA showed that Hg and Se in the bottlenose dolphin existed in the same place. Hg and Se in blood of inhabitants in a whaling town showed significant and positive correlations in both sexes. The increased Se in blood associated with the Hg level may play a role in protecting against MeHg toxicity in the inhabitants.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Methylmercury exposure and neurological outcomes in Taiji residents accustomed to consuming whale meat2014
Author(s)
Nakamura, M., Hachiya, N., Murata, KY., Nakanishi, I., Kondo, T., Yasutake, A., Miyamoto, KI., Ser, PH., Omi, S., Furusawa, H., Watanabe, C., Usuki, F., and Sakamoto, M.
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Journal Title
Environment International
Volume: 68
Pages: 25-32
DOI
Related Report
Peer Reviewed
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[Journal Article] Balancing the benefits of n-3 polyunsaturated fatty acids and the risks of methylmercury exposure from fish consumption2011
Author(s)
Mahaffey KR, Sunderland EM, Chan HM, Choi AL, Grandjean P, Marien K, Oken E, Sakamoto M, Schoeny R, Weihe P, Yan CH, Yasutake A
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Journal Title
Nutr Rev
Volume: 69(9)
Issue: 9
Pages: 493-508
DOI
Related Report
Peer Reviewed
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[Journal Article] Mercury exposure in female artisanal small-scale gold miners (ASGM) in Mongolia: An analysis of human biomonitoring (HBM) data from 2008.2011
Author(s)
Steckling N, Boese-O'Reilly S, Gradel C, Gutschmidt K, Shinee E, Altangerel E, Badrakh B, Bonduush I, Surenjav U, Ferstl P, Roider G, Sakamoto M, 他7名.
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Journal Title
The Science of the total environment.
Volume: 409(5)
Pages: 994-1000
Related Report
Peer Reviewed
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