| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Research Abstract |
The two-hit hypothesis is known as a hypothesis of onset mechanism of schizophrenia. It assumes that the onset of schizophrenia is originally attributed to vulnerability of a brain which stems from genetic or early developmental factors, and that exposure to later acquired factors such as stress triggers the onset. The present study examined whether rats with neonatal repeated treatment of an NMDA antagonist (MK-801), one of the animal models for schizophrenia, have stress-vulnerability. Rats with repeated neonatal MK-801 treatment were subjected to 20-day (5 days/week x 4 weeks) forced-swim stress in adulthood. After that, behavioral tests were carried out. The results do not show that these animals have stress-vulnerability.
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