| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Highly sensitive, cell-permeable fluorescent probes for specific metal ions have been developed. In our probe design, metal binding site and fluorescent moiety are combined in a molecule. The synthesized heavy metal targeted fluorescent probe was evaluated extra- and intracellular conditions.
By careful design of the ligand scaffolds, several fluorescent probes that exhibit specific response for zinc, cadmium, and mercury have been developed. The present results provide an important roadmap for designing future fluorescent probes.
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