| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Small additives have been developed that prevents protein aggregation and inactivation. Here, we have developed the polymers that prevent protein aggregation and protein stabilization, and also we have examined those molecular mechanisms. The molecular mechanism of polyethylene glycol as an aggregation suppressor was different mechanism from that of the well-used additive arginine hydrochloride. It was found that cationic polyallylamine and anionic polyacrylic acid bind on protein that stabilizes protein structure in aqueous solution. PEGylated polymer was more favorable as aggregation suppressor for aggregation-prone protein.
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