Investigation of the correlation between mechanical information and pathological information on plaque rupture using human carotid arteries obtained at autopsy
| Project/Area Number |
23560091
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Materials/Mechanics of materials
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| Research Institution | Kyushu Institute of Technology |
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Principal Investigator |
YAMADA Hiroshi 九州工業大学, 生命体工学研究科(研究院), 教授 (00220400)
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| Co-Investigator(Kenkyū-buntansha) |
SAKATA Noriyuki 福岡大学, 医学部, 教授 (20134273)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 粥状動脈硬化 / 応力－ひずみ関係 / 線維性被膜 / プラーク / コラーゲン / エラスチン / 繊維性被膜 / 動脈硬化 / 有限要素解析 / バイオメカニクス / 頸動脈 / 伸展試験 |
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| Research Abstract |
We compared the fibrous caps, which develop with plaques, with normal regions for human carotid arteries and thoracic aortas obtained at autopsy. A significant decrease of distensibility and significant increase of stress under uniaxial stretch were observed in fibrous caps, which were correlated with a significant increase of collagen and collagen type I as well as a significant decrease of elastin. We showed a significantly low level of pressure compared to the blood pressure through a finite element analysis of a carotid artery with a liquid-like lipid core. We also established an evaluation of the effect of three vascular layers in a ring-shaped coronary artery by stretching test of these layers and by finite element analysis with the initial geometry of these stress-released layers.
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Report
(4 results)
Research Products
(17 results)
