Structural analysis of the regulation of mitotic spindle orientation by the cell polarity protein LGN
| Project/Area Number |
23570141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
YUZAWA Satoru 九州大学, 医学(系)研究科(研究院), 助教 (40515029)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 細胞極性 / 細胞内シグナル伝達 / X線結晶構造解析 / 分子認識 / シグナル伝達 / タンパク質間相互作用 / モチーフ / 分子内相互作用 / 自己阻害状態 / 蛋白質間相互作用 / TPRモチーフ / 細胞極性の形成 / LGN |
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| Research Abstract |
Asymmetric cell division generates cell type diversity and is crucial for the development and tissue organization. The interactions between the cell polarity protein mInsc and LGN regulate mitotic spindle orientation during asymmetric cell division in certain types of cells. The complex of mInsc and LGN is targeted to plasma membrane and form complexes with other proteins. In this project, we have determined the crystal structure of LGN in complex with mInsc and elucidate the molecular mechanism of LGN regulated by its intramolecular interaction.
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Report
(4 results)
Research Products
(10 results)
