| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Research Abstract |
When the surface view of each epithelial cell is compared with a polygon, its sides correspond to cell–cell junctions, while its vertices correspond to tricellular contacts, whose roles in epithelial cell morphogenesis have not been well studied. We have shown that tricellulin, which is localized at tricellular contacts, regulates F-actin organization via Cdc42 and Tuba; a Cdc42 GEF. These findings indicate that tricellular contacts play crucial roles in regulating the actomyosin-mediated apical junctional complex tension through the tricellulin-Tuba-Cdc42 system.
|
